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Article: A pilot-randomized comparison of sublingual misoprostol with syntometrine on the blood loss in third stage of labor

TitleA pilot-randomized comparison of sublingual misoprostol with syntometrine on the blood loss in third stage of labor
Authors
KeywordsMeasured blood loss
Postpartum hemorrhage
Sublingual misoprostol
Issue Date2004
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0412
Citation
Acta Obstetricia Et Gynecologica Scandinavica, 2004, v. 83 n. 7, p. 647-650 How to Cite?
AbstractBackground. To compare sublingual misoprostol with intravenous syntometrine use during third stage of labor by measuring the blood loss. Methods. Sixty women were randomized to receive either 600 μg misoprostol sublingually or 1 ml syntometrine intravenously during the third stage of labor after spontaneous vaginal delivery. For those with risk factors of postpartum hemorrhage such as medical induction or augmentation of labor, previous third stage complications were excluded. The blood loss in labor was measured by the alkaline-hematin method, and differences in hemoglobin before and after delivery were compared. Results. There was no significant difference in the median measured blood loss between the misoprostol group and the syntometrine group (280 versus 226 ml, p = 0.45). The change in hemoglobin was comparable between the two groups. There were more women in the misoprostol group who required additional oxytocics, but the difference was not statistically significant. A major complication occurred in one patient in the misoprostol group with blood loss in excess of 1000 ml. The incidence of side effects such as shivering and pyrexia in women receiving misoprostol was significantly higher than that in the syntometrine group. Conclusion. The use of sublingual misoprostol or intravenous syntometrine in spontaneous vaginal delivery resulted in a comparable amount of blood loss. Transient side effect such as fever and shivering which resolved within a day occurred more frequent to those who received sublingual misoprostol. © Acta Obstet Gynecol Scand 83 2004.
Persistent Identifierhttp://hdl.handle.net/10722/87470
ISSN
2015 Impact Factor: 2.191
2015 SCImago Journal Rankings: 1.197
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, Hen_HK
dc.contributor.authorTang, OSen_HK
dc.contributor.authorLee, CPen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2010-09-06T09:30:04Z-
dc.date.available2010-09-06T09:30:04Z-
dc.date.issued2004en_HK
dc.identifier.citationActa Obstetricia Et Gynecologica Scandinavica, 2004, v. 83 n. 7, p. 647-650en_HK
dc.identifier.issn0001-6349en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87470-
dc.description.abstractBackground. To compare sublingual misoprostol with intravenous syntometrine use during third stage of labor by measuring the blood loss. Methods. Sixty women were randomized to receive either 600 μg misoprostol sublingually or 1 ml syntometrine intravenously during the third stage of labor after spontaneous vaginal delivery. For those with risk factors of postpartum hemorrhage such as medical induction or augmentation of labor, previous third stage complications were excluded. The blood loss in labor was measured by the alkaline-hematin method, and differences in hemoglobin before and after delivery were compared. Results. There was no significant difference in the median measured blood loss between the misoprostol group and the syntometrine group (280 versus 226 ml, p = 0.45). The change in hemoglobin was comparable between the two groups. There were more women in the misoprostol group who required additional oxytocics, but the difference was not statistically significant. A major complication occurred in one patient in the misoprostol group with blood loss in excess of 1000 ml. The incidence of side effects such as shivering and pyrexia in women receiving misoprostol was significantly higher than that in the syntometrine group. Conclusion. The use of sublingual misoprostol or intravenous syntometrine in spontaneous vaginal delivery resulted in a comparable amount of blood loss. Transient side effect such as fever and shivering which resolved within a day occurred more frequent to those who received sublingual misoprostol. © Acta Obstet Gynecol Scand 83 2004.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0412en_HK
dc.relation.ispartofActa Obstetricia et Gynecologica Scandinavicaen_HK
dc.subjectMeasured blood lossen_HK
dc.subjectPostpartum hemorrhageen_HK
dc.subjectSublingual misoprostolen_HK
dc.titleA pilot-randomized comparison of sublingual misoprostol with syntometrine on the blood loss in third stage of laboren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1936-0851&volume=83&spage=647&epage=650&date=2004&atitle=A+pilot-randomized+comparison+of+sublingual+misoprostol+with+syntometrine+on+the+blood+loss+in+third+stage+of+labor+en_HK
dc.identifier.emailHo, PC:pcho@hku.hken_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.0001-6349.2004.00572.xen_HK
dc.identifier.pmid15225189-
dc.identifier.scopuseid_2-s2.0-3142729033en_HK
dc.identifier.hkuros101001en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3142729033&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume83en_HK
dc.identifier.issue7en_HK
dc.identifier.spage647en_HK
dc.identifier.epage650en_HK
dc.identifier.isiWOS:000222287300007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLam, H=16022602300en_HK
dc.identifier.scopusauthoridTang, OS=36881248500en_HK
dc.identifier.scopusauthoridLee, CP=7410149538en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK

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