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Article: First-trimester maternal serum levels of placenta growth factor as predictor of preeclampsia and fetal growth restriction

TitleFirst-trimester maternal serum levels of placenta growth factor as predictor of preeclampsia and fetal growth restriction
Authors
Issue Date2001
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.greenjournal.org
Citation
Obstetrics And Gynecology, 2001, v. 98 n. 4, p. 608-611 How to Cite?
AbstractOBJECTIVE: To determine whether the reported decrease in maternal serum placenta growth factor concentration in preeclampsia is evident from the first trimester and before clinical onset of the disease. We also examined levels in pregnancies that subsequently resulted in fetal growth restriction (FGR). METHODS: Placenta growth factor concentration was measured in stored maternal serum samples obtained at 11-14 weeks of gestation from 131 women who subsequently developed preeclampsia, 137 women who subsequently developed FGR, and 400 randomly selected controls who did not develop preeclampsia or FGR. Preeclampsia was defined as diastolic blood pressure of 90 mmHg or more on two occasions 4 hours apart, accompanied by proteinuria (more than 300 mg of total protein in a 24-hour urine collection or a positive test for albumin on reagent strip) in women with no pre-existing hypertensive or renal disease. Fetal growth restriction was considered present if a woman subsequently delivered a live infant with a birth weight below the fifth centile for gestation. RESULTS: In the control group, maternal serum placenta growth factor concentration increased with gestation. Compared with the controls (median multiple of the median 0.98, standard deviation [SD] 0.51), levels in the preeclampsia group (median multiple of the median 1.09, SD 0.52) were not significantly different (t=1.83, P=.07), but in the FGR group (median multiple of the median 1.57, SD 0.74), levels were significantly increased (t=10.85, P < .001). CONCLUSION: The previously reported decrease in serum placenta growth factor levels in women with preeclampsia might not precede clinical onset of the disease and is not apparent in the first trimester of pregnancy. Levels are significantly increased in pregnancies resulting in FGR. © 2001 by the American College of Obstetricians and Gynecologists.
Persistent Identifierhttp://hdl.handle.net/10722/87461
ISSN
2015 Impact Factor: 5.656
2015 SCImago Journal Rankings: 2.899
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorOng, CYTen_HK
dc.contributor.authorLiao, AWen_HK
dc.contributor.authorCacho, AMen_HK
dc.contributor.authorSpencer, Ken_HK
dc.contributor.authorNicolaides, KHen_HK
dc.date.accessioned2010-09-06T09:29:57Z-
dc.date.available2010-09-06T09:29:57Z-
dc.date.issued2001en_HK
dc.identifier.citationObstetrics And Gynecology, 2001, v. 98 n. 4, p. 608-611en_HK
dc.identifier.issn0029-7844en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87461-
dc.description.abstractOBJECTIVE: To determine whether the reported decrease in maternal serum placenta growth factor concentration in preeclampsia is evident from the first trimester and before clinical onset of the disease. We also examined levels in pregnancies that subsequently resulted in fetal growth restriction (FGR). METHODS: Placenta growth factor concentration was measured in stored maternal serum samples obtained at 11-14 weeks of gestation from 131 women who subsequently developed preeclampsia, 137 women who subsequently developed FGR, and 400 randomly selected controls who did not develop preeclampsia or FGR. Preeclampsia was defined as diastolic blood pressure of 90 mmHg or more on two occasions 4 hours apart, accompanied by proteinuria (more than 300 mg of total protein in a 24-hour urine collection or a positive test for albumin on reagent strip) in women with no pre-existing hypertensive or renal disease. Fetal growth restriction was considered present if a woman subsequently delivered a live infant with a birth weight below the fifth centile for gestation. RESULTS: In the control group, maternal serum placenta growth factor concentration increased with gestation. Compared with the controls (median multiple of the median 0.98, standard deviation [SD] 0.51), levels in the preeclampsia group (median multiple of the median 1.09, SD 0.52) were not significantly different (t=1.83, P=.07), but in the FGR group (median multiple of the median 1.57, SD 0.74), levels were significantly increased (t=10.85, P < .001). CONCLUSION: The previously reported decrease in serum placenta growth factor levels in women with preeclampsia might not precede clinical onset of the disease and is not apparent in the first trimester of pregnancy. Levels are significantly increased in pregnancies resulting in FGR. © 2001 by the American College of Obstetricians and Gynecologists.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.greenjournal.orgen_HK
dc.relation.ispartofObstetrics and Gynecologyen_HK
dc.rightsObstetrics and Gynecology. Copyright © Lippincott Williams & Wilkins.en_HK
dc.titleFirst-trimester maternal serum levels of placenta growth factor as predictor of preeclampsia and fetal growth restrictionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0029-7844&volume=98&issue=4&spage=608&epage=611&date=2002&atitle=First-trimester+maternal+serum+levels+of+placenta+growth+factor+as+predictor+of+preeclampsia+and+fetal+growth+restrictionen_HK
dc.identifier.emailOng, CYT:cytong@hkucc.hku.hken_HK
dc.identifier.authorityOng, CYT=rp00482en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0029-7844(01)01528-9en_HK
dc.identifier.pmid11576576-
dc.identifier.scopuseid_2-s2.0-0034813234en_HK
dc.identifier.hkuros78769en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034813234&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume98en_HK
dc.identifier.issue4en_HK
dc.identifier.spage608en_HK
dc.identifier.epage611en_HK
dc.identifier.isiWOS:000171374400015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridOng, CYT=7401968192en_HK
dc.identifier.scopusauthoridLiao, AW=7006509060en_HK
dc.identifier.scopusauthoridCacho, AM=6603253417en_HK
dc.identifier.scopusauthoridSpencer, K=7202053140en_HK
dc.identifier.scopusauthoridNicolaides, KH=7203078780en_HK

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