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Article: Pilot study on the use of repeated doses of sublingual misoprostol in termination of pregnancy up to 12 weeks gestation: Efficacy and acceptability

TitlePilot study on the use of repeated doses of sublingual misoprostol in termination of pregnancy up to 12 weeks gestation: Efficacy and acceptability
Authors
KeywordsMedical abortion
Misoprostol
Sublingual
Issue Date2002
PublisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/
Citation
Human Reproduction, 2002, v. 17 n. 3, p. 654-658 How to Cite?
AbstractBackground: A sublingual misoprostol-alone regimen was used in 50 women requesting medical abortion at up to 12 weeks gestation. The efficacy and acceptability of this regimen were studied. Methods: The women were given 600 μg misoprostol sublingually every 3 h for a maximum of 5 doses. Results: The overall complete abortion rate was 86% (95% confidence interval: 74-93). The mean number of doses of misoprostol required was 4.1 ± 1.1. There was no significant change in haemoglobin concentration and the median duration of vaginal bleeding was 15 days (range: 7-56). Diarrhoea, fever and chills were the most common side-effects. The acceptability of this regimen of misoprostol was good: 97.7% of the women who had a complete abortion would choose this method again and 88.4% would recommend it to others. They preferred sublingual misoprostol as it is convenient to take, avoids the painful vaginal administration and gives more privacy during the abortion process. Conclusion: This regimen of sublingual misoprostol is an effective and acceptable method of medical abortion. Randomized controlled trials are required to compare the efficacy of various misoprostol-alone regimens of medical abortion. Pharmacokinetic studies and clinical trials are needed to find out the most appropriate dose, dosing interval and route of administration of misoprostol.
Persistent Identifierhttp://hdl.handle.net/10722/87451
ISSN
2015 Impact Factor: 4.621
2015 SCImago Journal Rankings: 2.271
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, OSen_HK
dc.contributor.authorMiao, BYen_HK
dc.contributor.authorLee, SWHen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2010-09-06T09:29:50Z-
dc.date.available2010-09-06T09:29:50Z-
dc.date.issued2002en_HK
dc.identifier.citationHuman Reproduction, 2002, v. 17 n. 3, p. 654-658en_HK
dc.identifier.issn0268-1161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87451-
dc.description.abstractBackground: A sublingual misoprostol-alone regimen was used in 50 women requesting medical abortion at up to 12 weeks gestation. The efficacy and acceptability of this regimen were studied. Methods: The women were given 600 μg misoprostol sublingually every 3 h for a maximum of 5 doses. Results: The overall complete abortion rate was 86% (95% confidence interval: 74-93). The mean number of doses of misoprostol required was 4.1 ± 1.1. There was no significant change in haemoglobin concentration and the median duration of vaginal bleeding was 15 days (range: 7-56). Diarrhoea, fever and chills were the most common side-effects. The acceptability of this regimen of misoprostol was good: 97.7% of the women who had a complete abortion would choose this method again and 88.4% would recommend it to others. They preferred sublingual misoprostol as it is convenient to take, avoids the painful vaginal administration and gives more privacy during the abortion process. Conclusion: This regimen of sublingual misoprostol is an effective and acceptable method of medical abortion. Randomized controlled trials are required to compare the efficacy of various misoprostol-alone regimens of medical abortion. Pharmacokinetic studies and clinical trials are needed to find out the most appropriate dose, dosing interval and route of administration of misoprostol.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/en_HK
dc.relation.ispartofHuman Reproductionen_HK
dc.rightsHuman Reproduction. Copyright © Oxford University Press.en_HK
dc.subjectMedical abortionen_HK
dc.subjectMisoprostolen_HK
dc.subjectSublingualen_HK
dc.titlePilot study on the use of repeated doses of sublingual misoprostol in termination of pregnancy up to 12 weeks gestation: Efficacy and acceptabilityen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-1161&volume=17&issue=3&spage=654&epage=658&date=2002&atitle=Pilot+study+on+the+use+of+repeated+doses+of+sublingual+misoprostol+in+termination+of+pregnancy+up+to+12+weeks+gestation:+efficacy+and+acceptabilityen_HK
dc.identifier.emailHo, PC:pcho@hku.hken_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11870118-
dc.identifier.scopuseid_2-s2.0-0036119768en_HK
dc.identifier.hkuros65639en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036119768&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume17en_HK
dc.identifier.issue3en_HK
dc.identifier.spage654en_HK
dc.identifier.epage658en_HK
dc.identifier.isiWOS:000174424600023-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTang, OS=7006723402en_HK
dc.identifier.scopusauthoridMiao, BY=7005706356en_HK
dc.identifier.scopusauthoridLee, SWH=26030998000en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK

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