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Article: Maternal serum level of placental growth factor in diabetic pregnancies

TitleMaternal serum level of placental growth factor in diabetic pregnancies
Authors
KeywordsDiabetes, gestational
Growth factors
Placental growth factor
Issue Date2004
PublisherJournal of Reproductive Medicine, Inc. The Journal's web site is located at http://www.reproductivemedicine.com
Citation
Journal Of Reproductive Medicine For The Obstetrician And Gynecologist, 2004, v. 49 n. 6, p. 477-480 How to Cite?
AbstractOBJECTIVE: To determine if maternal serum placental growth factor (PlGF) concentration at 11-14 weeks in pregnancies complicated by diabetes, including those with preexisting diabetes and those that developed gestational diabetes subsequently, differed from that in normal, uncomplicated pregnancies. STUDY DESIGN: PlGF concentration was measured in stored maternal serum samples obtained at 11-14 weeks of gestation from 82 women with diabetic pregnancies, including 32 with pre-existing diabetes and 50 with gestational diabetes, and 400 normal controls. Gestational diabetes mellitus was diagnosed with the 75-g oral glucose tolerance test and by applying World Health Organization criteria. RESULTS: When expressed as the multiple of the median and adjusted for gestation, the log transformed values of PlGF were significantly higher (P<.05) in the diabetic group (mean multiple of the median, [MoM] 1.14; SD 0.11) as compared to the controls (mean MoM, 1.00; SD, 0.11). On further comparison between the diabetic groups with the controls, significant differences were found in the groups with gestational diabetes (mean MoM, 1.15; SD, 0.12) and non-insulin dependent diabetes (mean MoM, 1.16; SD, 0.09) but not in those complicated by insulin-dependent diabetes (mean MoM, 1.09; SD, 0.10). CONCLUSION: These findings suggest that in the first trimester of pregnancy the level of maternal PlGF was already significantly increased not only in pregnancies complicated by non-insulin dependent diabetes but also in those with gestational diabetes. The implications of these findings remain to be explored.
Persistent Identifierhttp://hdl.handle.net/10722/87418
ISSN
2015 Impact Factor: 0.84
2015 SCImago Journal Rankings: 0.388
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorOng, CYTen_HK
dc.contributor.authorLao, TTen_HK
dc.contributor.authorSpencer, Ken_HK
dc.contributor.authorNicolaides, KHen_HK
dc.date.accessioned2010-09-06T09:29:24Z-
dc.date.available2010-09-06T09:29:24Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Reproductive Medicine For The Obstetrician And Gynecologist, 2004, v. 49 n. 6, p. 477-480en_HK
dc.identifier.issn0024-7758en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87418-
dc.description.abstractOBJECTIVE: To determine if maternal serum placental growth factor (PlGF) concentration at 11-14 weeks in pregnancies complicated by diabetes, including those with preexisting diabetes and those that developed gestational diabetes subsequently, differed from that in normal, uncomplicated pregnancies. STUDY DESIGN: PlGF concentration was measured in stored maternal serum samples obtained at 11-14 weeks of gestation from 82 women with diabetic pregnancies, including 32 with pre-existing diabetes and 50 with gestational diabetes, and 400 normal controls. Gestational diabetes mellitus was diagnosed with the 75-g oral glucose tolerance test and by applying World Health Organization criteria. RESULTS: When expressed as the multiple of the median and adjusted for gestation, the log transformed values of PlGF were significantly higher (P<.05) in the diabetic group (mean multiple of the median, [MoM] 1.14; SD 0.11) as compared to the controls (mean MoM, 1.00; SD, 0.11). On further comparison between the diabetic groups with the controls, significant differences were found in the groups with gestational diabetes (mean MoM, 1.15; SD, 0.12) and non-insulin dependent diabetes (mean MoM, 1.16; SD, 0.09) but not in those complicated by insulin-dependent diabetes (mean MoM, 1.09; SD, 0.10). CONCLUSION: These findings suggest that in the first trimester of pregnancy the level of maternal PlGF was already significantly increased not only in pregnancies complicated by non-insulin dependent diabetes but also in those with gestational diabetes. The implications of these findings remain to be explored.en_HK
dc.languageengen_HK
dc.publisherJournal of Reproductive Medicine, Inc. The Journal's web site is located at http://www.reproductivemedicine.comen_HK
dc.relation.ispartofJournal of Reproductive Medicine for the Obstetrician and Gynecologisten_HK
dc.subjectDiabetes, gestationalen_HK
dc.subjectGrowth factorsen_HK
dc.subjectPlacental growth factoren_HK
dc.titleMaternal serum level of placental growth factor in diabetic pregnanciesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1004-3845&volume=49&issue=6&spage=477&epage=480&date=2004&atitle=Maternal+serum+level+of+placental+growth+factor+in+diabetic+pregnanciesen_HK
dc.identifier.emailOng, CYT:cytong@hkucc.hku.hken_HK
dc.identifier.authorityOng, CYT=rp00482en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid15283058en_HK
dc.identifier.scopuseid_2-s2.0-2942689267en_HK
dc.identifier.hkuros89845en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2942689267&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume49en_HK
dc.identifier.issue6en_HK
dc.identifier.spage477en_HK
dc.identifier.epage480en_HK
dc.identifier.isiWOS:000222167800014-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridOng, CYT=7401968192en_HK
dc.identifier.scopusauthoridLao, TT=35327208900en_HK
dc.identifier.scopusauthoridSpencer, K=7202053140en_HK
dc.identifier.scopusauthoridNicolaides, KH=7203078780en_HK

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