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Article: The influence of ethnic origin on first trimester biochemical markers of chromosomal abnormalities

TitleThe influence of ethnic origin on first trimester biochemical markers of chromosomal abnormalities
Authors
KeywordsDown syndrome
Free β-hCG
PAPP-A
Prenatal screening
Trisomy 21
Issue Date2000
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 2000, v. 20 n. 6, p. 491-494 How to Cite?
AbstractIn a first trimester study of 5422 Caucasian women, 752 Afro-Caribbean women and 170 Asian women we have shown that the median maternal serum marker MoMs for free β-hCG and PAPP-A were 19% and 48% higher in Afro-Caribbean women and 19% higher and 35% higher in Asian women, compared to Caucasian women. Correcting for maternal weight made very little difference to the effect in Afro-Caribbeans (21% and 57% higher after weight correction) but reduced the effect in Asians (4% and 17% higher after weight correction). It is estimated that correcting for maternal weight and ethnicity overall would increase the detection rate by a modest 1.4%. However, the effect on an individual's risk could result in as much as a two-fold increase in the patient specific risk for trisomy 21. The impact of ethnic origin seems to be greater than that observed with second trimester biochemical markers and larger studies are required in order to develop robust algorithms for correcting for ethnic origin in the first trimester. Copyright (C) 2000 John Wiley and Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/87395
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSpencer, Ken_HK
dc.contributor.authorOng, CYTen_HK
dc.contributor.authorLiao, AWJen_HK
dc.contributor.authorNicolaides, KHen_HK
dc.date.accessioned2010-09-06T09:29:07Z-
dc.date.available2010-09-06T09:29:07Z-
dc.date.issued2000en_HK
dc.identifier.citationPrenatal Diagnosis, 2000, v. 20 n. 6, p. 491-494en_HK
dc.identifier.issn0197-3851en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87395-
dc.description.abstractIn a first trimester study of 5422 Caucasian women, 752 Afro-Caribbean women and 170 Asian women we have shown that the median maternal serum marker MoMs for free β-hCG and PAPP-A were 19% and 48% higher in Afro-Caribbean women and 19% higher and 35% higher in Asian women, compared to Caucasian women. Correcting for maternal weight made very little difference to the effect in Afro-Caribbeans (21% and 57% higher after weight correction) but reduced the effect in Asians (4% and 17% higher after weight correction). It is estimated that correcting for maternal weight and ethnicity overall would increase the detection rate by a modest 1.4%. However, the effect on an individual's risk could result in as much as a two-fold increase in the patient specific risk for trisomy 21. The impact of ethnic origin seems to be greater than that observed with second trimester biochemical markers and larger studies are required in order to develop robust algorithms for correcting for ethnic origin in the first trimester. Copyright (C) 2000 John Wiley and Sons, Ltd.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_HK
dc.relation.ispartofPrenatal Diagnosisen_HK
dc.rightsPrenatal Diagnosis. Copyright © John Wiley & Sons Ltd.en_HK
dc.subjectDown syndromeen_HK
dc.subjectFree β-hCGen_HK
dc.subjectPAPP-Aen_HK
dc.subjectPrenatal screeningen_HK
dc.subjectTrisomy 21en_HK
dc.titleThe influence of ethnic origin on first trimester biochemical markers of chromosomal abnormalitiesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0197-3851&volume=20&spage=491&epage=494&date=2002&atitle=The+influence+of+ethnic+origin+on+first+trimester+biochemical+markers+of+chromosomal+abnormalitiesen_HK
dc.identifier.emailOng, CYT:cytong@hkucc.hku.hken_HK
dc.identifier.authorityOng, CYT=rp00482en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/1097-0223(200006)20:6<491::AID-PD844>3.0.CO;2-3en_HK
dc.identifier.pmid10861715en_HK
dc.identifier.scopuseid_2-s2.0-0034121064en_HK
dc.identifier.hkuros79015en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034121064&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume20en_HK
dc.identifier.issue6en_HK
dc.identifier.spage491en_HK
dc.identifier.epage494en_HK
dc.identifier.isiWOS:000087823900009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridSpencer, K=7202053140en_HK
dc.identifier.scopusauthoridOng, CYT=7401968192en_HK
dc.identifier.scopusauthoridLiao, AWJ=7006509060en_HK
dc.identifier.scopusauthoridNicolaides, KH=7203078780en_HK

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