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Article: First-trimester maternal serum activin a in pre-eclampsia and fetal growth restriction

TitleFirst-trimester maternal serum activin a in pre-eclampsia and fetal growth restriction
Authors
KeywordsActivin A
Fetal growth restriction
First trimester
Pre-eclampsia
Issue Date2004
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/14767058.asp
Citation
Journal Of Maternal-Fetal And Neonatal Medicine, 2004, v. 15 n. 3, p. 176-180 How to Cite?
AbstractObjective: To investigate whether the reported increase in maternal serum activin A concentration in pre-eclampsia is evident from the first trimester. Design: This was a case-control study carried out in antenatal clinics among singleton pregnancies at 10-14 weeks of gestation. Methods: Activin A concentration was measured in stored maternal serum samples obtained at 11-14 weeks of gestation from 131 women who subsequently developed pre-eclampsia, 77 who developed non-proteinuric pregnancy-induced hypertension, 141 with fetal growth restriction in the absence of hypertensive complications and from 494 normotensive controls. Results: Compared to the median activin A level in the control group (1.00 MoM), the median MoM in the patients who subsequently developed pre-eclampsia and pregnancy-induced hypertension (1.49 MoM and 1.32 MoM, respectively) was significantly increased (p < 0.001), and in patients with fetal growth restriction (1.02 MoM) it was not significantly different (p = 0.57). In the pre-eclampsia group (n = 131) the disease was considered to be sufficiently severe to necessitate iatrogenic delivery before 35 weeks in 25 patients, and in this group the median MoM was 1.92. Conclusion: Maternal serum activin A concentration at 12 weeks of gestation in pregnancies which subsequently develop hypertensive disease is increased, whereas in those complicated by fetal growth restriction it is normal.
Persistent Identifierhttp://hdl.handle.net/10722/87386
ISSN
2015 Impact Factor: 1.674
2015 SCImago Journal Rankings: 0.810
References

 

DC FieldValueLanguage
dc.contributor.authorOng, CYTen_HK
dc.contributor.authorLiao, AWen_HK
dc.contributor.authorMunim, Sen_HK
dc.contributor.authorSpencer, Ken_HK
dc.contributor.authorNicolaides, KHen_HK
dc.date.accessioned2010-09-06T09:29:01Z-
dc.date.available2010-09-06T09:29:01Z-
dc.date.issued2004en_HK
dc.identifier.citationJournal Of Maternal-Fetal And Neonatal Medicine, 2004, v. 15 n. 3, p. 176-180en_HK
dc.identifier.issn1476-7058en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87386-
dc.description.abstractObjective: To investigate whether the reported increase in maternal serum activin A concentration in pre-eclampsia is evident from the first trimester. Design: This was a case-control study carried out in antenatal clinics among singleton pregnancies at 10-14 weeks of gestation. Methods: Activin A concentration was measured in stored maternal serum samples obtained at 11-14 weeks of gestation from 131 women who subsequently developed pre-eclampsia, 77 who developed non-proteinuric pregnancy-induced hypertension, 141 with fetal growth restriction in the absence of hypertensive complications and from 494 normotensive controls. Results: Compared to the median activin A level in the control group (1.00 MoM), the median MoM in the patients who subsequently developed pre-eclampsia and pregnancy-induced hypertension (1.49 MoM and 1.32 MoM, respectively) was significantly increased (p < 0.001), and in patients with fetal growth restriction (1.02 MoM) it was not significantly different (p = 0.57). In the pre-eclampsia group (n = 131) the disease was considered to be sufficiently severe to necessitate iatrogenic delivery before 35 weeks in 25 patients, and in this group the median MoM was 1.92. Conclusion: Maternal serum activin A concentration at 12 weeks of gestation in pregnancies which subsequently develop hypertensive disease is increased, whereas in those complicated by fetal growth restriction it is normal.en_HK
dc.languageengen_HK
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/14767058.aspen_HK
dc.relation.ispartofJournal of Maternal-Fetal and Neonatal Medicineen_HK
dc.rightsThe Journal of Maternal - Fetal & Neonatal Medicine. Copyright © Informa Healthcare.en_HK
dc.subjectActivin Aen_HK
dc.subjectFetal growth restrictionen_HK
dc.subjectFirst trimesteren_HK
dc.subjectPre-eclampsiaen_HK
dc.titleFirst-trimester maternal serum activin a in pre-eclampsia and fetal growth restrictionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1476-7058&volume=15&spage=176&epage=180&date=2004&atitle=First-trimester+maternal+serum+activin+A+in+pre-eclampsia+and+fetal+growth+restrictionen_HK
dc.identifier.emailOng, CYT:cytong@hkucc.hku.hken_HK
dc.identifier.authorityOng, CYT=rp00482en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/14767050410001668275en_HK
dc.identifier.pmid15280143-
dc.identifier.scopuseid_2-s2.0-2542466920en_HK
dc.identifier.hkuros87441en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2542466920&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issue3en_HK
dc.identifier.spage176en_HK
dc.identifier.epage180en_HK
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridOng, CYT=7401968192en_HK
dc.identifier.scopusauthoridLiao, AW=7006509060en_HK
dc.identifier.scopusauthoridMunim, S=6603159750en_HK
dc.identifier.scopusauthoridSpencer, K=7202053140en_HK
dc.identifier.scopusauthoridNicolaides, KH=7203078780en_HK

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