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Article: Neonatal hyperthyrotropinemia in gestational diabetes mellitus and perinatal complications

TitleNeonatal hyperthyrotropinemia in gestational diabetes mellitus and perinatal complications
Authors
KeywordsClinical neuroendocrinology
Diabetes mellitus
Hyperthyrotropinemia
Neonatal neuroendocrinology
Pregnancy
Thyrotropin
Issue Date2004
PublisherS Karger AG. The Journal's web site is located at http://www.karger.com/NEN
Citation
Neuroendocrinology, 2004, v. 80 n. 2, p. 124-128 How to Cite?
AbstractThe aim of this study is to explore the relationship between high cord blood thyroid-stimulating hormone (TSH) level and in-utero stress to the fetus in gestational diabetes mellitus (GDM). Cord blood TSH results were analyzed in 1,578 euthyroid infants from singleton pregnancies with GDM: 103 with elevated TSH (> 16 mIU/l) and 1,475 with normal TSH. Maternal characteristics, pregnancy outcome and perinatal complications were compared between the two groups. Multiple logistic regression was used to study the association between high cord blood TSH level and various perinatal complications which reflect in-utero stress in GDM after adjusting for the confounding effects of parity, instrumental delivery, cesarean section and baby gender. High cord blood TSH level was found to be associated with the 1-min Apgar score <7 (OR 3.31, 95% CI 1.78-6.16), birth trauma (OR 3.44, 95% CI 1.11-10.69), neonatal jaundice requiring treatment (OR 2.08, 95% CI 1.30-3.32), neonatal sepsis (OR 2.34, 95% CI 1.24-4.42), respiratory complications (OR 3.45, 95% CI 1.37-8.70), neurological complications (OR 8.01, 95% CI 1.91-33.60) and overall perinatal morbidity (OR 2.41, 95% CI 1.58-3.67). Cord blood TSH level seems to be a better and independent indicator of the in-utero stress to the fetus in GDM when compared to the commonly used sugar profile result and HbA1c level. Copyright © 2004 S. Karger AG, Basel.
Persistent Identifierhttp://hdl.handle.net/10722/87363
ISSN
2015 Impact Factor: 2.583
2015 SCImago Journal Rankings: 1.479
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, WCen_HK
dc.contributor.authorChan, KKLen_HK
dc.contributor.authorLao, TTen_HK
dc.date.accessioned2010-09-06T09:28:42Z-
dc.date.available2010-09-06T09:28:42Z-
dc.date.issued2004en_HK
dc.identifier.citationNeuroendocrinology, 2004, v. 80 n. 2, p. 124-128en_HK
dc.identifier.issn0028-3835en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87363-
dc.description.abstractThe aim of this study is to explore the relationship between high cord blood thyroid-stimulating hormone (TSH) level and in-utero stress to the fetus in gestational diabetes mellitus (GDM). Cord blood TSH results were analyzed in 1,578 euthyroid infants from singleton pregnancies with GDM: 103 with elevated TSH (> 16 mIU/l) and 1,475 with normal TSH. Maternal characteristics, pregnancy outcome and perinatal complications were compared between the two groups. Multiple logistic regression was used to study the association between high cord blood TSH level and various perinatal complications which reflect in-utero stress in GDM after adjusting for the confounding effects of parity, instrumental delivery, cesarean section and baby gender. High cord blood TSH level was found to be associated with the 1-min Apgar score <7 (OR 3.31, 95% CI 1.78-6.16), birth trauma (OR 3.44, 95% CI 1.11-10.69), neonatal jaundice requiring treatment (OR 2.08, 95% CI 1.30-3.32), neonatal sepsis (OR 2.34, 95% CI 1.24-4.42), respiratory complications (OR 3.45, 95% CI 1.37-8.70), neurological complications (OR 8.01, 95% CI 1.91-33.60) and overall perinatal morbidity (OR 2.41, 95% CI 1.58-3.67). Cord blood TSH level seems to be a better and independent indicator of the in-utero stress to the fetus in GDM when compared to the commonly used sugar profile result and HbA1c level. Copyright © 2004 S. Karger AG, Basel.en_HK
dc.languageengen_HK
dc.publisherS Karger AG. The Journal's web site is located at http://www.karger.com/NENen_HK
dc.relation.ispartofNeuroendocrinologyen_HK
dc.rightsNeuroendocrinology. Copyright © S Karger AG.en_HK
dc.subjectClinical neuroendocrinologyen_HK
dc.subjectDiabetes mellitusen_HK
dc.subjectHyperthyrotropinemiaen_HK
dc.subjectNeonatal neuroendocrinologyen_HK
dc.subjectPregnancyen_HK
dc.subjectThyrotropinen_HK
dc.titleNeonatal hyperthyrotropinemia in gestational diabetes mellitus and perinatal complicationsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0028-3835&volume=80&spage=124&epage=128&date=2004&atitle=Neonatal+hyperthyrotropinemia+in+gestational+diabetes+mellitus+and+perinatal+complicationsen_HK
dc.identifier.emailChan, KKL:kklchan@hkucc.hku.hken_HK
dc.identifier.authorityChan, KKL=rp00499en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000081375en_HK
dc.identifier.pmid15475663-
dc.identifier.scopuseid_2-s2.0-10844228092en_HK
dc.identifier.hkuros96774en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-10844228092&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume80en_HK
dc.identifier.issue2en_HK
dc.identifier.spage124en_HK
dc.identifier.epage128en_HK
dc.identifier.isiWOS:000225258600006-
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridLeung, WC=7201504435en_HK
dc.identifier.scopusauthoridChan, KKL=8655666700en_HK
dc.identifier.scopusauthoridLao, TT=35275381600en_HK

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