File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: A comparison of isosorbide mononitrate and misoprostol cervical ripening before suction evacuation

TitleA comparison of isosorbide mononitrate and misoprostol cervical ripening before suction evacuation
Authors
Issue Date2003
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.greenjournal.org
Citation
Obstetrics And Gynecology, 2003, v. 102 n. 3, p. 583-588 How to Cite?
AbstractOBJECTIVE: To compare the efficacy of a nitric oxide donor (isosorbide mononitrate) and a prostaglandin E 1 analogue (misoprostol) for cervical priming before suction termination of pregnancy. METHODS: This was a randomized, double blind, placebo-controlled trial. One hundred twenty-six healthy women requesting termination of pregnancy between 9 and 12 weeks' gestation were recruited. Women were randomized into three groups: control, isosorbide mononitrate, and misoprostol. All women were given moistened intravaginal study drugs (placebo, 40 mg of isosorbide mononitrate, or 400 μg of misoprostol) 4-6 hours before suction evacuation. Side effects were assessed 3 hours after drug administration. The cervical dilatation and the cumulative force required to dilate the cervix to 8 mm were measured by a cervical tonometer before suction evacuation. Operative blood loss was measured after sieving off the products of gestation. RESULTS: There were no differences in the baseline cervical dilatation, cumulative force, and operative blood loss between the isosorbide mononitrate and placebo groups. However, women in the misoprostol group had a significantly greater cervical dilatation, required less cumulative force, and had less blood loss than women in the isosorbide mononitrate or control group. The majority (more than 80%) of women in all three groups found their cervical priming agents acceptable. CONCLUSION: Intravaginal isosorbide mononitrate was less effective than misoprostol in cervical ripening before suction termination of pregnancy. © 2003 by The American College of Obstetricians and Gynecologists.
Persistent Identifierhttp://hdl.handle.net/10722/87340
ISSN
2015 Impact Factor: 5.656
2015 SCImago Journal Rankings: 2.899
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, CFIen_HK
dc.contributor.authorChan, CWCen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2010-09-06T09:28:24Z-
dc.date.available2010-09-06T09:28:24Z-
dc.date.issued2003en_HK
dc.identifier.citationObstetrics And Gynecology, 2003, v. 102 n. 3, p. 583-588en_HK
dc.identifier.issn0029-7844en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87340-
dc.description.abstractOBJECTIVE: To compare the efficacy of a nitric oxide donor (isosorbide mononitrate) and a prostaglandin E 1 analogue (misoprostol) for cervical priming before suction termination of pregnancy. METHODS: This was a randomized, double blind, placebo-controlled trial. One hundred twenty-six healthy women requesting termination of pregnancy between 9 and 12 weeks' gestation were recruited. Women were randomized into three groups: control, isosorbide mononitrate, and misoprostol. All women were given moistened intravaginal study drugs (placebo, 40 mg of isosorbide mononitrate, or 400 μg of misoprostol) 4-6 hours before suction evacuation. Side effects were assessed 3 hours after drug administration. The cervical dilatation and the cumulative force required to dilate the cervix to 8 mm were measured by a cervical tonometer before suction evacuation. Operative blood loss was measured after sieving off the products of gestation. RESULTS: There were no differences in the baseline cervical dilatation, cumulative force, and operative blood loss between the isosorbide mononitrate and placebo groups. However, women in the misoprostol group had a significantly greater cervical dilatation, required less cumulative force, and had less blood loss than women in the isosorbide mononitrate or control group. The majority (more than 80%) of women in all three groups found their cervical priming agents acceptable. CONCLUSION: Intravaginal isosorbide mononitrate was less effective than misoprostol in cervical ripening before suction termination of pregnancy. © 2003 by The American College of Obstetricians and Gynecologists.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.greenjournal.orgen_HK
dc.relation.ispartofObstetrics and Gynecologyen_HK
dc.rightsObstetrics and Gynecology. Copyright © Lippincott Williams & Wilkins.en_HK
dc.titleA comparison of isosorbide mononitrate and misoprostol cervical ripening before suction evacuationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0029-7844&volume=102&issue=3&spage=583&epage=588&date=2003&atitle=A+comparison+of+isosorbide+mononitrate+and+misoprostol+cervical+ripening+before+suction+evacuationen_HK
dc.identifier.emailHo, PC:pcho@hku.hken_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0029-7844(03)00514-3en_HK
dc.identifier.scopuseid_2-s2.0-0141990495en_HK
dc.identifier.hkuros87494en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0141990495&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume102en_HK
dc.identifier.issue3en_HK
dc.identifier.spage583en_HK
dc.identifier.epage588en_HK
dc.identifier.isiWOS:000185007400028-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLi, CFI=7501686453en_HK
dc.identifier.scopusauthoridChan, CWC=7404813871en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats