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Article: A comparison of two regimens of intravaginal misoprostol for termination of second trimester pregnancy: A randomized comparative trial

TitleA comparison of two regimens of intravaginal misoprostol for termination of second trimester pregnancy: A randomized comparative trial
Authors
KeywordsMisoprostol
Second trimester abortion
Issue Date2000
PublisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/
Citation
Human Reproduction, 2000, v. 15 n. 3, p. 709-712 How to Cite?
AbstractA prospective randomized trial was conducted in 148 women to compare the efficacy of two regimens of vaginal misoprostol for termination of second trimester pregnancy. Women aged 16-40 years requesting termination of second trimester pregnancy were randomized into two groups. Women in group 1 were given vaginal misoprostol 400 μg every 3 h for a maximum of five doses in 24 h. Women in group 2 were given vaginal misoprostol 400 μg every 6 h for a maximum of three doses in 24 h. If women did not abort in 24 h, the same regimen was repeated. The median induction-abortion interval in group 1 (15.2 h) was significantly shorter (P < 0.01) than that in the group 2 (19.0 h). The percentage of women who achieved successful abortion within 48 h in group 1 (90.5%) was also significantly higher (P < 0.02) than that in group 2 (75.7%). The incidence of fever was more common in group 1 (P = 0.01). It is concluded that the regimen of vaginal misoprostol 400 μg every 3 h with maximum of five doses in 24 h was more effective than the regimen of misoprostol every 6 h in termination of second trimester pregnancy.
Persistent Identifierhttp://hdl.handle.net/10722/87306
ISSN
2015 Impact Factor: 4.621
2015 SCImago Journal Rankings: 2.271
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, KSen_HK
dc.contributor.authorNgai, CSWen_HK
dc.contributor.authorYeo, ELKen_HK
dc.contributor.authorTang, LCHen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2010-09-06T09:27:59Z-
dc.date.available2010-09-06T09:27:59Z-
dc.date.issued2000en_HK
dc.identifier.citationHuman Reproduction, 2000, v. 15 n. 3, p. 709-712en_HK
dc.identifier.issn0268-1161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87306-
dc.description.abstractA prospective randomized trial was conducted in 148 women to compare the efficacy of two regimens of vaginal misoprostol for termination of second trimester pregnancy. Women aged 16-40 years requesting termination of second trimester pregnancy were randomized into two groups. Women in group 1 were given vaginal misoprostol 400 μg every 3 h for a maximum of five doses in 24 h. Women in group 2 were given vaginal misoprostol 400 μg every 6 h for a maximum of three doses in 24 h. If women did not abort in 24 h, the same regimen was repeated. The median induction-abortion interval in group 1 (15.2 h) was significantly shorter (P < 0.01) than that in the group 2 (19.0 h). The percentage of women who achieved successful abortion within 48 h in group 1 (90.5%) was also significantly higher (P < 0.02) than that in group 2 (75.7%). The incidence of fever was more common in group 1 (P = 0.01). It is concluded that the regimen of vaginal misoprostol 400 μg every 3 h with maximum of five doses in 24 h was more effective than the regimen of misoprostol every 6 h in termination of second trimester pregnancy.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/en_HK
dc.relation.ispartofHuman Reproductionen_HK
dc.rightsHuman Reproduction. Copyright © Oxford University Press.en_HK
dc.subjectMisoprostolen_HK
dc.subjectSecond trimester abortionen_HK
dc.titleA comparison of two regimens of intravaginal misoprostol for termination of second trimester pregnancy: A randomized comparative trialen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-1161&volume=15&issue=3&spage=709&epage=712&date=2000&atitle=A+comparison+of+two+regimens+of+intravaginal+misoprostol+for+termination+of+second+trimester+pregnancy:+a+randomized+comparative+trialen_HK
dc.identifier.emailTang, LCH: lchtang@hku.hken_HK
dc.identifier.emailHo, PC: pcho@hku.hken_HK
dc.identifier.authorityTang, LCH=rp01756en_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/humrep/15.3.709-
dc.identifier.pmid10686224en_HK
dc.identifier.scopuseid_2-s2.0-0034008632en_HK
dc.identifier.hkuros49686en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034008632&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume15en_HK
dc.identifier.issue3en_HK
dc.identifier.spage709en_HK
dc.identifier.epage712en_HK
dc.identifier.isiWOS:000085670900040-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWong, KS=36341790700en_HK
dc.identifier.scopusauthoridNgai, CSW=6603676357en_HK
dc.identifier.scopusauthoridYeo, ELK=8139882600en_HK
dc.identifier.scopusauthoridTang, LCH=7402081111en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK

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