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Article: A randomized double-blind placebo-controlled study to assess the effect of oral contraceptive pills on the outcome of medical abortion with mifepristone and misoprostol

TitleA randomized double-blind placebo-controlled study to assess the effect of oral contraceptive pills on the outcome of medical abortion with mifepristone and misoprostol
Authors
KeywordsMifepristone
Misoprostol
Oral contraceptive pills
Post-abortion bleeding
Issue Date1999
PublisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/
Citation
Human Reproduction, 1999, v. 14 n. 3, p. 722-725 How to Cite?
AbstractThis was a randomized double-blind placebo-controlled trial to determine the effect of oral contraceptive (OC) pills taken immediately after medical abortion on the duration of bleeding and complete abortion rate. Two hundred women in the first 49 days of pregnancy were given 200 mg mifepristone orally followed by 400 μg misoprostol vaginally 48 h later. One day later, they were randomized to receive either OC pills (30 μg of ethinyl oestradiol and 0.15 mg of levonorgestrel per tablet) or placebo for 21 days. The complete abortion rates were 98% in the OC group and 99% in the placebo group. The median duration of bleeding was similar: 17 (range: 5-57) days in the OC group and 16 (range: 6-55) days in the placebo group. In the OC group there was a small but significant fall in the haemoglobin concentration by 14 days (5.3 g/dl) after administration of mifepristone. The incidence of side-effects was similar in the two groups. We conclude that the use of OC pills does not decrease the duration of bleeding after medical abortion nor does it affect the abortion rate.
Persistent Identifierhttp://hdl.handle.net/10722/87287
ISSN
2015 Impact Factor: 4.621
2015 SCImago Journal Rankings: 2.271
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, OSen_HK
dc.contributor.authorGao, PPen_HK
dc.contributor.authorCheng, Len_HK
dc.contributor.authorLee, SWHen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2010-09-06T09:27:44Z-
dc.date.available2010-09-06T09:27:44Z-
dc.date.issued1999en_HK
dc.identifier.citationHuman Reproduction, 1999, v. 14 n. 3, p. 722-725en_HK
dc.identifier.issn0268-1161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87287-
dc.description.abstractThis was a randomized double-blind placebo-controlled trial to determine the effect of oral contraceptive (OC) pills taken immediately after medical abortion on the duration of bleeding and complete abortion rate. Two hundred women in the first 49 days of pregnancy were given 200 mg mifepristone orally followed by 400 μg misoprostol vaginally 48 h later. One day later, they were randomized to receive either OC pills (30 μg of ethinyl oestradiol and 0.15 mg of levonorgestrel per tablet) or placebo for 21 days. The complete abortion rates were 98% in the OC group and 99% in the placebo group. The median duration of bleeding was similar: 17 (range: 5-57) days in the OC group and 16 (range: 6-55) days in the placebo group. In the OC group there was a small but significant fall in the haemoglobin concentration by 14 days (5.3 g/dl) after administration of mifepristone. The incidence of side-effects was similar in the two groups. We conclude that the use of OC pills does not decrease the duration of bleeding after medical abortion nor does it affect the abortion rate.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://humrep.oxfordjournals.org/en_HK
dc.relation.ispartofHuman Reproductionen_HK
dc.rightsHuman Reproduction. Copyright © Oxford University Press.en_HK
dc.subjectMifepristoneen_HK
dc.subjectMisoprostolen_HK
dc.subjectOral contraceptive pillsen_HK
dc.subjectPost-abortion bleedingen_HK
dc.titleA randomized double-blind placebo-controlled study to assess the effect of oral contraceptive pills on the outcome of medical abortion with mifepristone and misoprostolen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0268-1161&volume=14&issue=3&spage=722&epage=725&date=1999&atitle=A+randomized+double-blind+placebo-controlled+study+to+assess+the+effect+of+oral+contraceptive+pills+on+the+outcome+of+medical+abortion+with+mifepristone+and+misoprostolen_HK
dc.identifier.emailHo, PC:pcho@hku.hken_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid10221703-
dc.identifier.scopuseid_2-s2.0-0033038333en_HK
dc.identifier.hkuros41890en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033038333&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume14en_HK
dc.identifier.issue3en_HK
dc.identifier.spage722en_HK
dc.identifier.epage725en_HK
dc.identifier.isiWOS:000079389100029-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTang, OS=7006723402en_HK
dc.identifier.scopusauthoridGao, PP=7201740368en_HK
dc.identifier.scopusauthoridCheng, L=34869443100en_HK
dc.identifier.scopusauthoridLee, SWH=26030998000en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK

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