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Article: Maternal serum activin A and inhibin A in trisomy 18 pregnancies at 10-14 weeks

TitleMaternal serum activin A and inhibin A in trisomy 18 pregnancies at 10-14 weeks
Authors
KeywordsActivin
Aneuploidy
First trimester
Free β-hCG
Inhibin
Nuchal translucency
PAPP-A
Prenatal screening
Trisomy 18
Issue Date2001
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 2001, v. 21 n. 7, p. 571-574 How to Cite?
AbstractIn 45 cases of trisomy 18 and 493 control pregnancies at 10-14 weeks of gestation, maternal serum inhibin A, total activin A, free β-hCG and PAPP-A were measured. In the trisomy 18 pregnancies the median values were 0.74 MoM for inhibin A, 1.23 MoM for activin A, 0.38 MoM for free β-hCG and 0.16 MoM for PAPP-A. The degree of deviation from normal in the levels of inhibin and activin is small in comparison with free β-hCG and PAPP-A and they are therefore unlikely to be of value in improving the sensitivity of 90% for a 1% false-positive rate achieved by screening with fetal nuchal translucency and maternal serum free β-hCG and PAPP-A. Copyright © 2001 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/87251
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSpencer, Ken_HK
dc.contributor.authorLiao, AWen_HK
dc.contributor.authorOng, CYTen_HK
dc.contributor.authorFlack, NJen_HK
dc.contributor.authorNicolaides, KHen_HK
dc.date.accessioned2010-09-06T09:27:17Z-
dc.date.available2010-09-06T09:27:17Z-
dc.date.issued2001en_HK
dc.identifier.citationPrenatal Diagnosis, 2001, v. 21 n. 7, p. 571-574en_HK
dc.identifier.issn0197-3851en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87251-
dc.description.abstractIn 45 cases of trisomy 18 and 493 control pregnancies at 10-14 weeks of gestation, maternal serum inhibin A, total activin A, free β-hCG and PAPP-A were measured. In the trisomy 18 pregnancies the median values were 0.74 MoM for inhibin A, 1.23 MoM for activin A, 0.38 MoM for free β-hCG and 0.16 MoM for PAPP-A. The degree of deviation from normal in the levels of inhibin and activin is small in comparison with free β-hCG and PAPP-A and they are therefore unlikely to be of value in improving the sensitivity of 90% for a 1% false-positive rate achieved by screening with fetal nuchal translucency and maternal serum free β-hCG and PAPP-A. Copyright © 2001 John Wiley & Sons, Ltd.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_HK
dc.relation.ispartofPrenatal Diagnosisen_HK
dc.rightsPrenatal Diagnosis. Copyright © John Wiley & Sons Ltd.en_HK
dc.subjectActivinen_HK
dc.subjectAneuploidyen_HK
dc.subjectFirst trimesteren_HK
dc.subjectFree β-hCGen_HK
dc.subjectInhibinen_HK
dc.subjectNuchal translucencyen_HK
dc.subjectPAPP-Aen_HK
dc.subjectPrenatal screeningen_HK
dc.subjectTrisomy 18en_HK
dc.titleMaternal serum activin A and inhibin A in trisomy 18 pregnancies at 10-14 weeksen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0197-3851&volume=21&spage=571&epage=574&date=2002&atitle=Maternal+serum+activin+A+and+inhibin+A+in+trisomy+18+pregnancies+at+10-14+weeksen_HK
dc.identifier.emailOng, CYT:cytong@hkucc.hku.hken_HK
dc.identifier.authorityOng, CYT=rp00482en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/pd.125en_HK
dc.identifier.pmid11494294en_HK
dc.identifier.scopuseid_2-s2.0-0034878941en_HK
dc.identifier.hkuros78772en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034878941&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue7en_HK
dc.identifier.spage571en_HK
dc.identifier.epage574en_HK
dc.identifier.isiWOS:000170478700011-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridSpencer, K=7202053140en_HK
dc.identifier.scopusauthoridLiao, AW=7006509060en_HK
dc.identifier.scopusauthoridOng, CYT=7401968192en_HK
dc.identifier.scopusauthoridFlack, NJ=6603487468en_HK
dc.identifier.scopusauthoridNicolaides, KH=7203078780en_HK

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