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Article: Maternal serum levels of dimeric inhibin A in pregnancies affected by trisomy 21 in the first trimester

TitleMaternal serum levels of dimeric inhibin A in pregnancies affected by trisomy 21 in the first trimester
Authors
KeywordsAneuploidy
First trimester
Free β-hCG
Inhibin
PAPP-A
Prenatal screening
Trisomy 21
Issue Date2001
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 2001, v. 21 n. 6, p. 441-444 How to Cite?
AbstractDimeric inhibin A was measured in maternal serum samples from 45 pregnancies affected by trisomy 21 and 493 samples from unaffected pregnancies at 10-14 weeks of gestation. Inhibin A levels in affected pregnancies were compared with levels of free β-hCG and PAPP-A in the same series. In the trisomy 21 group, the median multiple of the median (MoM) inhibin A was not significantly elevated (1.28 vs 1.00) with only 15.5% being above the 95th centile. In contrast, the median MoM free β-hCG was significantly increased (2.05 vs 1.00) with 36% above the 95th centile and PAPP-A was significantly reduced (0.49 vs 1.00) with 42% below the 5th centile. Inhibin A levels in the trisomy 21 group were significantly correlated with gestational age such that median levels rose from 1.04 at 11 weeks to 1.30 at 12 weeks and 1.67 at 13 weeks. These findings suggest that first trimester biochemical screening for trisomy 21, which is currently optimised using maternal serum free β-hCG and PAPP-A and fetal nuchal translucency, will not benefit from the inclusion of inhibin A. Copyright © 2001 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/87206
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSpencer, Ken_HK
dc.contributor.authorLiao, AWen_HK
dc.contributor.authorOng, CYTen_HK
dc.contributor.authorGeerts, Len_HK
dc.contributor.authorNicolaides, KHen_HK
dc.date.accessioned2010-09-06T09:26:41Z-
dc.date.available2010-09-06T09:26:41Z-
dc.date.issued2001en_HK
dc.identifier.citationPrenatal Diagnosis, 2001, v. 21 n. 6, p. 441-444en_HK
dc.identifier.issn0197-3851en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87206-
dc.description.abstractDimeric inhibin A was measured in maternal serum samples from 45 pregnancies affected by trisomy 21 and 493 samples from unaffected pregnancies at 10-14 weeks of gestation. Inhibin A levels in affected pregnancies were compared with levels of free β-hCG and PAPP-A in the same series. In the trisomy 21 group, the median multiple of the median (MoM) inhibin A was not significantly elevated (1.28 vs 1.00) with only 15.5% being above the 95th centile. In contrast, the median MoM free β-hCG was significantly increased (2.05 vs 1.00) with 36% above the 95th centile and PAPP-A was significantly reduced (0.49 vs 1.00) with 42% below the 5th centile. Inhibin A levels in the trisomy 21 group were significantly correlated with gestational age such that median levels rose from 1.04 at 11 weeks to 1.30 at 12 weeks and 1.67 at 13 weeks. These findings suggest that first trimester biochemical screening for trisomy 21, which is currently optimised using maternal serum free β-hCG and PAPP-A and fetal nuchal translucency, will not benefit from the inclusion of inhibin A. Copyright © 2001 John Wiley & Sons, Ltd.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_HK
dc.relation.ispartofPrenatal Diagnosisen_HK
dc.rightsPrenatal Diagnosis. Copyright © John Wiley & Sons Ltd.en_HK
dc.subjectAneuploidyen_HK
dc.subjectFirst trimesteren_HK
dc.subjectFree β-hCGen_HK
dc.subjectInhibinen_HK
dc.subjectPAPP-Aen_HK
dc.subjectPrenatal screeningen_HK
dc.subjectTrisomy 21en_HK
dc.titleMaternal serum levels of dimeric inhibin A in pregnancies affected by trisomy 21 in the first trimesteren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0197-3851&volume=21&spage=441&epage=444&date=2001&atitle=Maternal+serum+levels+of+dimeric+inhibin+A+in+pregnancies+affected+by+trisomy+21+in+the+first+trimesteren_HK
dc.identifier.emailOng, CYT:cytong@hkucc.hku.hken_HK
dc.identifier.authorityOng, CYT=rp00482en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/pd.98en_HK
dc.identifier.pmid11438945-
dc.identifier.scopuseid_2-s2.0-0034916243en_HK
dc.identifier.hkuros78797en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034916243&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume21en_HK
dc.identifier.issue6en_HK
dc.identifier.spage441en_HK
dc.identifier.epage444en_HK
dc.identifier.isiWOS:000169865500002-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridSpencer, K=7202053140en_HK
dc.identifier.scopusauthoridLiao, AW=7006509060en_HK
dc.identifier.scopusauthoridOng, CYT=7401968192en_HK
dc.identifier.scopusauthoridGeerts, L=7004884716en_HK
dc.identifier.scopusauthoridNicolaides, KH=7203078780en_HK

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