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Article: The synthesis and fate of glycodelin in human ovary during folliculogenesis

TitleThe synthesis and fate of glycodelin in human ovary during folliculogenesis
Authors
KeywordsCumulus cells
Follicle
Glycodelin
Granulosa cells
Ovary
Issue Date2002
PublisherOxford University Press. The Journal's web site is located at http://molehr.oxfordjournals.org/
Citation
Molecular Human Reproduction, 2002, v. 8 n. 2, p. 142-148 How to Cite?
AbstractThe ontogeny of glycodelin in human ovarian follicles during folliculogenesis was studied. Glycodelin immunoreactivity began to be detected in the granulosa cells and thecal cells of late secondary follicles. Immunoreactivity was also found in both the luteinized granulosa cells and cumulus cells obtained from women undergoing the assisted reproduction treatment. However, only the luteinized granulosa cells, and not the cumulus cells, expressed glycodelin mRNA. Results also showed that the cumulus cells took up radiolabelled glycodelin and partially deglycosylated some of it. Glycodelin (and a partially deglycolsylated form of glycoldelin) appeared to complex with two cytoplasmic or membrane components of the cumulus cells. The data also demonstrated that ZIF-1, a glycoprotein isolated from human follicular fluid, was immunologically similar to glycodelin. In conclusion, we suggest that glycodelin is synthesized in the granulosa cells of ovarian follicles at late secondary follicle stage. It then may be released into the follicular fluid from where it is taken up and partially modified by the cumulus cells.
Persistent Identifierhttp://hdl.handle.net/10722/87198
ISSN
2015 Impact Factor: 3.943
2015 SCImago Journal Rankings: 1.611
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTse, JYMen_HK
dc.contributor.authorChiu, PCNen_HK
dc.contributor.authorLee, KFen_HK
dc.contributor.authorSeppala, Men_HK
dc.contributor.authorKoistinen, Hen_HK
dc.contributor.authorKoistinen, Ren_HK
dc.contributor.authorYao, YQen_HK
dc.contributor.authorYeung, WSBen_HK
dc.date.accessioned2010-09-06T09:26:35Z-
dc.date.available2010-09-06T09:26:35Z-
dc.date.issued2002en_HK
dc.identifier.citationMolecular Human Reproduction, 2002, v. 8 n. 2, p. 142-148en_HK
dc.identifier.issn1360-9947en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87198-
dc.description.abstractThe ontogeny of glycodelin in human ovarian follicles during folliculogenesis was studied. Glycodelin immunoreactivity began to be detected in the granulosa cells and thecal cells of late secondary follicles. Immunoreactivity was also found in both the luteinized granulosa cells and cumulus cells obtained from women undergoing the assisted reproduction treatment. However, only the luteinized granulosa cells, and not the cumulus cells, expressed glycodelin mRNA. Results also showed that the cumulus cells took up radiolabelled glycodelin and partially deglycosylated some of it. Glycodelin (and a partially deglycolsylated form of glycoldelin) appeared to complex with two cytoplasmic or membrane components of the cumulus cells. The data also demonstrated that ZIF-1, a glycoprotein isolated from human follicular fluid, was immunologically similar to glycodelin. In conclusion, we suggest that glycodelin is synthesized in the granulosa cells of ovarian follicles at late secondary follicle stage. It then may be released into the follicular fluid from where it is taken up and partially modified by the cumulus cells.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://molehr.oxfordjournals.org/en_HK
dc.relation.ispartofMolecular Human Reproductionen_HK
dc.rightsMolecular Human Reproduction. Copyright © Oxford University Press.en_HK
dc.subjectCumulus cellsen_HK
dc.subjectFollicleen_HK
dc.subjectGlycodelinen_HK
dc.subjectGranulosa cellsen_HK
dc.subjectOvaryen_HK
dc.titleThe synthesis and fate of glycodelin in human ovary during folliculogenesisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1360-9947&volume=8&issue=2&spage=142&epage=148&date=2002&atitle=The+synthesis+and+fate+of+glycodelin+in+human+ovary+during+folliculogenesisen_HK
dc.identifier.emailChiu, PCN:pchiucn@hku.hken_HK
dc.identifier.emailLee, KF:ckflee@hku.hken_HK
dc.identifier.emailYeung, WSB:wsbyeung@hkucc.hku.hken_HK
dc.identifier.authorityChiu, PCN=rp00424en_HK
dc.identifier.authorityLee, KF=rp00458en_HK
dc.identifier.authorityYeung, WSB=rp00331en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid11818517-
dc.identifier.scopuseid_2-s2.0-0036167939en_HK
dc.identifier.hkuros66882en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036167939&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume8en_HK
dc.identifier.issue2en_HK
dc.identifier.spage142en_HK
dc.identifier.epage148en_HK
dc.identifier.isiWOS:000173754400006-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridTse, JYM=7102607314en_HK
dc.identifier.scopusauthoridChiu, PCN=25959969200en_HK
dc.identifier.scopusauthoridLee, KF=26643097500en_HK
dc.identifier.scopusauthoridSeppala, M=35475165300en_HK
dc.identifier.scopusauthoridKoistinen, H=7003612125en_HK
dc.identifier.scopusauthoridKoistinen, R=7006574669en_HK
dc.identifier.scopusauthoridYao, YQ=7403567431en_HK
dc.identifier.scopusauthoridYeung, WSB=7102370745en_HK

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