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Article: Further evaluation on long-term depot-medroxyprogesterone acetate use and bone mineral density: A longitudinal cohort study

TitleFurther evaluation on long-term depot-medroxyprogesterone acetate use and bone mineral density: A longitudinal cohort study
Authors
KeywordsBone loss
Bone mineral density
Depot-medroxyprogesterone acetate
Longitudinal study
Issue Date2000
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/contraception
Citation
Contraception, 2000, v. 62 n. 4, p. 161-164 How to Cite?
AbstractCross-sectional studies on the effects of depot-medroxyprogesterone acetate (DMPA) on bone mineral density (BMD) have been controversial. The present longitudinal cohort study on 59 Chinese women over a period of 3 years has shown that their annual rate of bone loss at 3 sites (0.44% in lumbar spine, 0.40% in neck of femur, 1.05% in Ward's triangle) was substantially less than the projected values (1.1% in lumbar spine, 2.3% in neck of femur, 3.5% in Ward's triangle) in a cross-sectional study that had demonstrated a significant reduction in BMD in DMPA users than the non-user population. The trochanter BMD measurement did not show the projected annual bone loss of 2.4%. The rate of bone loss is probably non-linear, with a rapid loss in the first 5 years and a leveling off afterwards. The duration of DMPA use was not significantly correlated with the rate of bone loss. Multiple linear regression analysis demonstrated that age and body mass index were significant variables in modeling the rate of bone loss in the lumbar spine and neck of femur, but not in the trochanter and Ward's triangle areas. The Z scores also suggested a retardation in bone loss with time and potentially due to the effect of progesterone in decreasing bone turnover that is similar to the situation in postmenopausal women. The present data provide another aspect of reassurance to the long-term use of DMPA. © 2000 Elsevier Science Inc.
Persistent Identifierhttp://hdl.handle.net/10722/87153
ISSN
2015 Impact Factor: 2.788
2015 SCImago Journal Rankings: 1.557
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, OSen_HK
dc.contributor.authorTang, Gen_HK
dc.contributor.authorYip, PSFen_HK
dc.contributor.authorLi, Ben_HK
dc.date.accessioned2010-09-06T09:26:00Z-
dc.date.available2010-09-06T09:26:00Z-
dc.date.issued2000en_HK
dc.identifier.citationContraception, 2000, v. 62 n. 4, p. 161-164en_HK
dc.identifier.issn0010-7824en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87153-
dc.description.abstractCross-sectional studies on the effects of depot-medroxyprogesterone acetate (DMPA) on bone mineral density (BMD) have been controversial. The present longitudinal cohort study on 59 Chinese women over a period of 3 years has shown that their annual rate of bone loss at 3 sites (0.44% in lumbar spine, 0.40% in neck of femur, 1.05% in Ward's triangle) was substantially less than the projected values (1.1% in lumbar spine, 2.3% in neck of femur, 3.5% in Ward's triangle) in a cross-sectional study that had demonstrated a significant reduction in BMD in DMPA users than the non-user population. The trochanter BMD measurement did not show the projected annual bone loss of 2.4%. The rate of bone loss is probably non-linear, with a rapid loss in the first 5 years and a leveling off afterwards. The duration of DMPA use was not significantly correlated with the rate of bone loss. Multiple linear regression analysis demonstrated that age and body mass index were significant variables in modeling the rate of bone loss in the lumbar spine and neck of femur, but not in the trochanter and Ward's triangle areas. The Z scores also suggested a retardation in bone loss with time and potentially due to the effect of progesterone in decreasing bone turnover that is similar to the situation in postmenopausal women. The present data provide another aspect of reassurance to the long-term use of DMPA. © 2000 Elsevier Science Inc.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/contraceptionen_HK
dc.relation.ispartofContraceptionen_HK
dc.rightsContraception. Copyright © Elsevier Inc.en_HK
dc.subjectBone lossen_HK
dc.subjectBone mineral densityen_HK
dc.subjectDepot-medroxyprogesterone acetateen_HK
dc.subjectLongitudinal studyen_HK
dc.titleFurther evaluation on long-term depot-medroxyprogesterone acetate use and bone mineral density: A longitudinal cohort studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0010-7824&volume=62&spage=161&epage=164&date=2000&atitle=Further+evaluation+on+long-term+depot-medroxyprogesterone+acetate+use+and+bone+mineral+density:+a+longitudinal+cohort+studyen_HK
dc.identifier.emailTang, G: gwktang@hkucc.hku.hken_HK
dc.identifier.emailYip, PSF: sfpyip@hku.hken_HK
dc.identifier.authorityTang, G=rp00328en_HK
dc.identifier.authorityYip, PSF=rp00596en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0010-7824(00)00168-2en_HK
dc.identifier.pmid11137068-
dc.identifier.scopuseid_2-s2.0-0034538414en_HK
dc.identifier.hkuros56425en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034538414&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume62en_HK
dc.identifier.issue4en_HK
dc.identifier.spage161en_HK
dc.identifier.epage164en_HK
dc.identifier.isiWOS:000166072500001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTang, OS=36881248500en_HK
dc.identifier.scopusauthoridTang, G=7401633864en_HK
dc.identifier.scopusauthoridYip, PSF=7102503720en_HK
dc.identifier.scopusauthoridLi, B=15767862000en_HK

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