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Article: The pharmacokinetics and different regimens of misoprostol in early first-trimester medical abortion

TitleThe pharmacokinetics and different regimens of misoprostol in early first-trimester medical abortion
Authors
KeywordsMedical abortion
Misoprostol
Pharmacokinetics
Issue Date2006
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/contraception
Citation
Contraception, 2006, v. 74 n. 1, p. 26-30 How to Cite?
AbstractMisoprostol is a synthetic prostaglandin E1 analogue that is commonly used for medical abortion. It can be given orally, vaginally and sublingually. A pharmacokinetic study has shown that sublingual misoprostol has the shortest onset of action, the highest peak concentration and the greatest bioavailability among the three routes of administration. Earlier clinical trials have shown that vaginal misoprostol is superior to oral misoprostol when combined with mifepristone for early first-trimester medical abortion. Recent studies on the clinical efficacy of sublingual misoprostol have demonstrated that it is as effective as vaginal misoprostol. Further studies are required to determine the optimal dose and route of administration of misoprostol that can give the highest complete abortion rate, lowest ongoing pregnancy rate and least side effects. © 2006 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/87084
ISSN
2015 Impact Factor: 2.788
2015 SCImago Journal Rankings: 1.557
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, OSen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2010-09-06T09:25:07Z-
dc.date.available2010-09-06T09:25:07Z-
dc.date.issued2006en_HK
dc.identifier.citationContraception, 2006, v. 74 n. 1, p. 26-30en_HK
dc.identifier.issn0010-7824en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87084-
dc.description.abstractMisoprostol is a synthetic prostaglandin E1 analogue that is commonly used for medical abortion. It can be given orally, vaginally and sublingually. A pharmacokinetic study has shown that sublingual misoprostol has the shortest onset of action, the highest peak concentration and the greatest bioavailability among the three routes of administration. Earlier clinical trials have shown that vaginal misoprostol is superior to oral misoprostol when combined with mifepristone for early first-trimester medical abortion. Recent studies on the clinical efficacy of sublingual misoprostol have demonstrated that it is as effective as vaginal misoprostol. Further studies are required to determine the optimal dose and route of administration of misoprostol that can give the highest complete abortion rate, lowest ongoing pregnancy rate and least side effects. © 2006 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/contraceptionen_HK
dc.relation.ispartofContraceptionen_HK
dc.rightsContraception. Copyright © Elsevier Inc.en_HK
dc.subjectMedical abortionen_HK
dc.subjectMisoprostolen_HK
dc.subjectPharmacokineticsen_HK
dc.titleThe pharmacokinetics and different regimens of misoprostol in early first-trimester medical abortionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0010-7824&volume=74&spage=26&epage=30&date=2006&atitle=The+pharmacokinetics+and+different+regimens+of+misoprostol+in+early+first-trimester+medical+abortionen_HK
dc.identifier.emailHo, PC:pcho@hku.hken_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.contraception.2006.03.005en_HK
dc.identifier.pmid16781256-
dc.identifier.scopuseid_2-s2.0-33745012138en_HK
dc.identifier.hkuros124216en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745012138&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume74en_HK
dc.identifier.issue1en_HK
dc.identifier.spage26en_HK
dc.identifier.epage30en_HK
dc.identifier.isiWOS:000238728400006-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridTang, OS=7006723402en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK

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