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Article: A prospective randomized control study to compare the effect of serum and a commercial serum substitute (Plasmanate) on the outcome of assisted reproduction program

TitleA prospective randomized control study to compare the effect of serum and a commercial serum substitute (Plasmanate) on the outcome of assisted reproduction program
Authors
KeywordsIVF
Plasma fraction
Plasmanate
Protein supplement
Serum
Issue Date1998
PublisherBlackwell Publishing Asia.
Citation
Journal Of Obstetrics And Gynaecology Research, 1998, v. 24 n. 1, p. 77-81 How to Cite?
AbstractObjectives: To compare the effect of supplementation of serum and Plasmanate, a commercial serum substitute, to culture medium on the IVF outcome. Methods: One hundred eighty-nine subfertile couples were prospective randomized into the serum and the Plasmanate group during their IVF treatment. In vitro experiment was also performed to determine the fraction of Plasmanate that might affect embryo development. Results: The pregnancy rate were similar in both groups. The fertilization rate, the number of gestational sacs and good quality spare embryos suitable for cryopreservation were higher in the serum group than the Plasmanate group. However, these differences did not reach statistical significance. Significantly more embryos in the former cleaved to more than 4 cells at the time of transfer than the latter (p < 0.05). Ultrafiltration study showed that this inhibitory effect resided in the low molecular weight fraction (< 30-kD) of Plasmanate. Conclusions: Serum is slightly better than Plasmanate as a protein supplement. However, Plasmanate may still be used for short term embryo culture in assisted reproduction.
Persistent Identifierhttp://hdl.handle.net/10722/87075
ISSN
2015 Impact Factor: 1.091
2015 SCImago Journal Rankings: 0.521
References

 

DC FieldValueLanguage
dc.contributor.authorYeung, WSBen_HK
dc.contributor.authorLau, EYLen_HK
dc.contributor.authorNg, VKHen_HK
dc.contributor.authorCheung, TMen_HK
dc.contributor.authorSo, WWKen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2010-09-06T09:25:00Z-
dc.date.available2010-09-06T09:25:00Z-
dc.date.issued1998en_HK
dc.identifier.citationJournal Of Obstetrics And Gynaecology Research, 1998, v. 24 n. 1, p. 77-81en_HK
dc.identifier.issn1341-8076en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87075-
dc.description.abstractObjectives: To compare the effect of supplementation of serum and Plasmanate, a commercial serum substitute, to culture medium on the IVF outcome. Methods: One hundred eighty-nine subfertile couples were prospective randomized into the serum and the Plasmanate group during their IVF treatment. In vitro experiment was also performed to determine the fraction of Plasmanate that might affect embryo development. Results: The pregnancy rate were similar in both groups. The fertilization rate, the number of gestational sacs and good quality spare embryos suitable for cryopreservation were higher in the serum group than the Plasmanate group. However, these differences did not reach statistical significance. Significantly more embryos in the former cleaved to more than 4 cells at the time of transfer than the latter (p < 0.05). Ultrafiltration study showed that this inhibitory effect resided in the low molecular weight fraction (< 30-kD) of Plasmanate. Conclusions: Serum is slightly better than Plasmanate as a protein supplement. However, Plasmanate may still be used for short term embryo culture in assisted reproduction.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Asia.en_HK
dc.relation.ispartofJournal of Obstetrics and Gynaecology Researchen_HK
dc.subjectIVFen_HK
dc.subjectPlasma fractionen_HK
dc.subjectPlasmanateen_HK
dc.subjectProtein supplementen_HK
dc.subjectSerumen_HK
dc.titleA prospective randomized control study to compare the effect of serum and a commercial serum substitute (Plasmanate) on the outcome of assisted reproduction programen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1341-8076&volume=24&issue=1&spage=77&epage=81&date=1997&atitle=A+Prospective+Randomized+Control+Study+to+Compare+the+Effect+of+Serum+and+a+Commercial+Serum+Substitute+(Plasmanate)+on+the+Outcome+of+Assisted+Reproduction+Programen_HK
dc.identifier.emailYeung, WSB:wsbyeung@hkucc.hku.hken_HK
dc.identifier.emailHo, PC:pcho@hku.hken_HK
dc.identifier.authorityYeung, WSB=rp00331en_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9564110-
dc.identifier.scopuseid_2-s2.0-0031881373en_HK
dc.identifier.hkuros31654en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0031881373&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue1en_HK
dc.identifier.spage77en_HK
dc.identifier.epage81en_HK
dc.publisher.placeAustraliaen_HK
dc.identifier.scopusauthoridYeung, WSB=7102370745en_HK
dc.identifier.scopusauthoridLau, EYL=7103086093en_HK
dc.identifier.scopusauthoridNg, VKH=55196752400en_HK
dc.identifier.scopusauthoridCheung, TM=7103334551en_HK
dc.identifier.scopusauthoridSo, WWK=36849240200en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK

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