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Article: The influence of parity and gravidity on first trimester markers of chromosomal abnormality

TitleThe influence of parity and gravidity on first trimester markers of chromosomal abnormality
Authors
KeywordsChromosomal abnormality
Dawn syndrome
Free β-hCG
Nuchal translucency
PAPP-A
Prenatal screening
Trisomy 21
Issue Date2000
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 2000, v. 20 n. 10, p. 792-794 How to Cite?
AbstractWe have studied changes in first trimester fetal nuchal translucency (NT) and maternal serum free β-hCG and PAPP-A with gravidity and parity in 3252 singleton pregnancies unaffected by chromosomal abnormality or major pregnancy complications. We have shown that gravidity and parity is associated with a small but progressive decrease in fetal NT and a small but progressive increase in free β-hCG and PAPPA. None of these small changes with increasing gravidity or parity are statistically significant and hence correction for these variables is not necessary when considering first trimester screening for chromosomal abnormalities. Copyright (C) 2000 John Wiley and Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/87066
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSpencer, Ken_HK
dc.contributor.authorOng, CYTen_HK
dc.contributor.authorLiao, AWJen_HK
dc.contributor.authorNicolaides, KHen_HK
dc.date.accessioned2010-09-06T09:24:52Z-
dc.date.available2010-09-06T09:24:52Z-
dc.date.issued2000en_HK
dc.identifier.citationPrenatal Diagnosis, 2000, v. 20 n. 10, p. 792-794en_HK
dc.identifier.issn0197-3851en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87066-
dc.description.abstractWe have studied changes in first trimester fetal nuchal translucency (NT) and maternal serum free β-hCG and PAPP-A with gravidity and parity in 3252 singleton pregnancies unaffected by chromosomal abnormality or major pregnancy complications. We have shown that gravidity and parity is associated with a small but progressive decrease in fetal NT and a small but progressive increase in free β-hCG and PAPPA. None of these small changes with increasing gravidity or parity are statistically significant and hence correction for these variables is not necessary when considering first trimester screening for chromosomal abnormalities. Copyright (C) 2000 John Wiley and Sons, Ltd.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_HK
dc.relation.ispartofPrenatal Diagnosisen_HK
dc.rightsPrenatal Diagnosis. Copyright © John Wiley & Sons Ltd.en_HK
dc.subjectChromosomal abnormalityen_HK
dc.subjectDawn syndromeen_HK
dc.subjectFree β-hCGen_HK
dc.subjectNuchal translucencyen_HK
dc.subjectPAPP-Aen_HK
dc.subjectPrenatal screeningen_HK
dc.subjectTrisomy 21en_HK
dc.titleThe influence of parity and gravidity on first trimester markers of chromosomal abnormalityen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0197-3851&volume=20&spage=792&epage=794&date=2002&atitle=The+influence+of+parity+and+gravidity+on+first+trimester+markers+of+chromosomal+abnormalityen_HK
dc.identifier.emailOng, CYT:cytong@hkucc.hku.hken_HK
dc.identifier.authorityOng, CYT=rp00482en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/1097-0223(200010)20:10<792::AID-PD914>3.0.CO;2-5en_HK
dc.identifier.pmid11038455-
dc.identifier.scopuseid_2-s2.0-0033745809en_HK
dc.identifier.hkuros78801en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0033745809&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume20en_HK
dc.identifier.issue10en_HK
dc.identifier.spage792en_HK
dc.identifier.epage794en_HK
dc.identifier.isiWOS:000090020200004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridSpencer, K=7202053140en_HK
dc.identifier.scopusauthoridOng, CYT=7401968192en_HK
dc.identifier.scopusauthoridLiao, AWJ=7006509060en_HK
dc.identifier.scopusauthoridNicolaides, KH=7203078780en_HK

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