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Article: The Effect of Mifepristone on the Expression of Steroid Hormone Receptors in Human Decidua and Placenta: A Randomized Placebo-Controlled Double-Blind Study

TitleThe Effect of Mifepristone on the Expression of Steroid Hormone Receptors in Human Decidua and Placenta: A Randomized Placebo-Controlled Double-Blind Study
Authors
Issue Date2003
PublisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.org
Citation
Journal Of Clinical Endocrinology And Metabolism, 2003, v. 88 n. 12, p. 5846-5850 How to Cite?
AbstractThe objective of this study was to investigate the expression of steroid hormone receptors in human first trimester placenta and decidua and whether such expression was altered after mifepristone treatment. One hundred women who requested termination of pregnancy between 7 and 12 wk were randomly assigned to receive placebo or 200 mg mifepristone at 12, 24, and 48 h before suction evacuation of uterus. Immunohistochemistry was used to detect the expression of progesterone receptor, estrogen receptor, glucocorticoid receptor (GB), and androgen receptor. Progesterone receptor expression in both placenta and decidua tissues was not affected by mifepristone treatment. Estrogen receptor was identified in a decidual gland in only one sample. Androgen receptor was not expressed in either tissue. The expression of GR in decidual stromal cells was suppressed by mifepristone, and the effect was detectable at 12 h after administration. The expression of GR in decidual glands was not affected. In the placenta, the expression of GR in cytotrophoblasts and villous stromal cells was suppressed by mifepristone; the effect was detectable at 12 h and persisted at 48 h. In conclusion, the suppressed GR expression after mifepristone administration may be part of the mechanism of mifepristone in causing abortion.
Persistent Identifierhttp://hdl.handle.net/10722/87064
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.940
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, CCWen_HK
dc.contributor.authorLao, TTen_HK
dc.contributor.authorHo, PCen_HK
dc.contributor.authorSung, EOPen_HK
dc.contributor.authorCheung, ANYen_HK
dc.date.accessioned2010-09-06T09:24:51Z-
dc.date.available2010-09-06T09:24:51Z-
dc.date.issued2003en_HK
dc.identifier.citationJournal Of Clinical Endocrinology And Metabolism, 2003, v. 88 n. 12, p. 5846-5850en_HK
dc.identifier.issn0021-972Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/87064-
dc.description.abstractThe objective of this study was to investigate the expression of steroid hormone receptors in human first trimester placenta and decidua and whether such expression was altered after mifepristone treatment. One hundred women who requested termination of pregnancy between 7 and 12 wk were randomly assigned to receive placebo or 200 mg mifepristone at 12, 24, and 48 h before suction evacuation of uterus. Immunohistochemistry was used to detect the expression of progesterone receptor, estrogen receptor, glucocorticoid receptor (GB), and androgen receptor. Progesterone receptor expression in both placenta and decidua tissues was not affected by mifepristone treatment. Estrogen receptor was identified in a decidual gland in only one sample. Androgen receptor was not expressed in either tissue. The expression of GR in decidual stromal cells was suppressed by mifepristone, and the effect was detectable at 12 h after administration. The expression of GR in decidual glands was not affected. In the placenta, the expression of GR in cytotrophoblasts and villous stromal cells was suppressed by mifepristone; the effect was detectable at 12 h and persisted at 48 h. In conclusion, the suppressed GR expression after mifepristone administration may be part of the mechanism of mifepristone in causing abortion.en_HK
dc.languageengen_HK
dc.publisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.orgen_HK
dc.relation.ispartofJournal of Clinical Endocrinology and Metabolismen_HK
dc.rightsJournal of Clinical Endocrinology and Metabolism. Copyright © The Endocrine Society.en_HK
dc.subject.meshAbortifacient Agents, Steroidal - pharmacologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAndrogen Receptor Antagonistsen_HK
dc.subject.meshDecidua - metabolismen_HK
dc.subject.meshDouble-Blind Methoden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshMifepristone - pharmacologyen_HK
dc.subject.meshPlacebosen_HK
dc.subject.meshPlacenta - metabolismen_HK
dc.subject.meshPregnancyen_HK
dc.subject.meshReceptors, Estrogen - antagonists & inhibitorsen_HK
dc.subject.meshReceptors, Glucocorticoid - metabolismen_HK
dc.subject.meshReceptors, Progesterone - metabolismen_HK
dc.subject.meshReceptors, Steroid - metabolismen_HK
dc.titleThe Effect of Mifepristone on the Expression of Steroid Hormone Receptors in Human Decidua and Placenta: A Randomized Placebo-Controlled Double-Blind Studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-972X&volume=88&issue=12&spage=5846&epage=5850&date=2003&atitle=The+effect+of+mifepristone+on+the+expression+of+steroid+hormone+receptors+in+human+decidua+and+placenta:+a+randomized+placebo-controlled+double-blind+studyen_HK
dc.identifier.emailHo, PC:pcho@hku.hken_HK
dc.identifier.emailCheung, ANY:anycheun@hkucc.hku.hken_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1210/jc.2003-030958en_HK
dc.identifier.pmid14671179-
dc.identifier.scopuseid_2-s2.0-0346732362en_HK
dc.identifier.hkuros86867en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0346732362&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume88en_HK
dc.identifier.issue12en_HK
dc.identifier.spage5846en_HK
dc.identifier.epage5850en_HK
dc.identifier.isiWOS:000187184400043-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, CCW=26643394500en_HK
dc.identifier.scopusauthoridLao, TT=7005722132en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK
dc.identifier.scopusauthoridSung, EOP=7006254250en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK

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