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Article: A prospective randomised comparison of sublingual and vaginal misoprostol in second trimester termination of pregnancy

TitleA prospective randomised comparison of sublingual and vaginal misoprostol in second trimester termination of pregnancy
Authors
Issue Date2004
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJOG
Citation
BJOG: An International Journal Of Obstetrics And Gynaecology, 2004, v. 111 n. 9, p. 1001-1005 How to Cite?
AbstractObjective: To compare the efficacy, side effects and acceptability of sublingual and vaginal misoprostol for second trimester medical abortion. Design: Prospective randomised controlled trial. Setting: Tertiary referral unit and a teaching hospital. Population: Two hundred and twenty-four women at 12 to 20 weeks of gestation. Methods: The women were randomised to receive either sublingual or vaginal misoprostol 400 μg every 3 hours for a maximum of five doses. The course of misoprostol was repeated if the woman did not abort within 24 hours. Main outcome measures: The success rate at 48 hours, induction-to-abortion interval and the side effects. Results: There was no significant difference in the success rate at 48 hours (sublingual: 91%; vaginal: 95%). However, the success rate at 24 hours was significantly higher in the vaginal group (85%) compared with the sublingual group (64%). There was no difference in the median induction-to-abortion interval (sublingual: 13.8 hours; vaginal: 12.0 hours). Significantly more women in the sublingual group preferred the route to which they were assigned when compared with the vaginal group. The incidence of fever was also less in the sublingual group. Conclusion: The use of vaginal misoprostol for second trimester medical abortion resulted in a higher success rate than sublingual misoprostol at 24 hours but the abortion rate was similar at 48 hours. Vaginal misoprostol should be the regimen of choice but sublingual misoprostol is also an effective alternative.
Persistent Identifierhttp://hdl.handle.net/10722/87045
ISSN
2015 Impact Factor: 4.039
2015 SCImago Journal Rankings: 2.083
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorOi, STen_HK
dc.contributor.authorLau, WNTen_HK
dc.contributor.authorChan, CCWen_HK
dc.contributor.authorPak, CHen_HK
dc.date.accessioned2010-09-06T09:24:36Z-
dc.date.available2010-09-06T09:24:36Z-
dc.date.issued2004en_HK
dc.identifier.citationBJOG: An International Journal Of Obstetrics And Gynaecology, 2004, v. 111 n. 9, p. 1001-1005en_HK
dc.identifier.issn1470-0328en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87045-
dc.description.abstractObjective: To compare the efficacy, side effects and acceptability of sublingual and vaginal misoprostol for second trimester medical abortion. Design: Prospective randomised controlled trial. Setting: Tertiary referral unit and a teaching hospital. Population: Two hundred and twenty-four women at 12 to 20 weeks of gestation. Methods: The women were randomised to receive either sublingual or vaginal misoprostol 400 μg every 3 hours for a maximum of five doses. The course of misoprostol was repeated if the woman did not abort within 24 hours. Main outcome measures: The success rate at 48 hours, induction-to-abortion interval and the side effects. Results: There was no significant difference in the success rate at 48 hours (sublingual: 91%; vaginal: 95%). However, the success rate at 24 hours was significantly higher in the vaginal group (85%) compared with the sublingual group (64%). There was no difference in the median induction-to-abortion interval (sublingual: 13.8 hours; vaginal: 12.0 hours). Significantly more women in the sublingual group preferred the route to which they were assigned when compared with the vaginal group. The incidence of fever was also less in the sublingual group. Conclusion: The use of vaginal misoprostol for second trimester medical abortion resulted in a higher success rate than sublingual misoprostol at 24 hours but the abortion rate was similar at 48 hours. Vaginal misoprostol should be the regimen of choice but sublingual misoprostol is also an effective alternative.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/BJOGen_HK
dc.relation.ispartofBJOG: An International Journal of Obstetrics and Gynaecologyen_HK
dc.rightsBritish Journal of Obstetrics & Gynaecology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subject.meshAbortifacient Agents, Nonsteroidal - administration & dosageen_HK
dc.subject.meshAbortion, Induced - methodsen_HK
dc.subject.meshAdministration, Intravaginalen_HK
dc.subject.meshAdministration, Sublingualen_HK
dc.subject.meshAdulten_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMisoprostol - administration & dosageen_HK
dc.subject.meshPregnancyen_HK
dc.subject.meshPregnancy Trimester, Seconden_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.titleA prospective randomised comparison of sublingual and vaginal misoprostol in second trimester termination of pregnancyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0306-5456&volume=111&spage=1001&epage=1005&date=2004&atitle=A+prospective+randomised+comparison+of+sublingual+and+vaginal+misoprostol+in+second+trimester+termination+of+pregnancyen_HK
dc.identifier.emailPak, CH:pcho@hku.hken_HK
dc.identifier.authorityPak, CH=rp00325en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.1471-0528.2004.00222.xen_HK
dc.identifier.pmid15327617-
dc.identifier.scopuseid_2-s2.0-4544314276en_HK
dc.identifier.hkuros101011en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4544314276&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume111en_HK
dc.identifier.issue9en_HK
dc.identifier.spage1001en_HK
dc.identifier.epage1005en_HK
dc.identifier.isiWOS:000223900100018-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridOi, ST=7103241843en_HK
dc.identifier.scopusauthoridLau, WNT=36847553600en_HK
dc.identifier.scopusauthoridChan, CCW=26643394500en_HK
dc.identifier.scopusauthoridPak, CH=7402211440en_HK

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