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Article: A study of the efficacy of cervical ripening with nitric oxide donor versus placebo for cervical priming before second-trimester termination of pregnancy

TitleA study of the efficacy of cervical ripening with nitric oxide donor versus placebo for cervical priming before second-trimester termination of pregnancy
Authors
KeywordsCervical priming
Nitric oxide donor
Second-trimester induced abortion
Issue Date2003
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/contraception
Citation
Contraception, 2003, v. 68 n. 4, p. 269-272 How to Cite?
AbstractThis was a double-blind randomized control study to evaluate the efficacy of cervical priming by nitric oxide donor before second-trimester induced abortion. One-hundred healthy women with a singleton pregnancy between 14 and 20 weeks of gestation were randomized into either 40 mg isosorbide mononitrate or placebo, given intravaginally 12 h before induction. This was followed by intravaginal misoprostol induction. The induction-abortion interval, abortion rate, side effects and the woman's acceptability of the priming agent were recorded. All women completed the study and there was no severe complication recorded. There was no significant difference in the induction-abortion interval and abortion rate between the two groups. Isosorbide mononitrate group reported significantly more side effects of headache. More than 90% of the women in both groups found the priming agent acceptable. The application of intravaginal nitric oxide donors prior to the prostaglandins induction did not significantly improve the second-trimester induced-abortion process. © 2003 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/87033
ISSN
2015 Impact Factor: 2.788
2015 SCImago Journal Rankings: 1.557
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, CFIen_HK
dc.contributor.authorChan, CWCen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2010-09-06T09:24:26Z-
dc.date.available2010-09-06T09:24:26Z-
dc.date.issued2003en_HK
dc.identifier.citationContraception, 2003, v. 68 n. 4, p. 269-272en_HK
dc.identifier.issn0010-7824en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87033-
dc.description.abstractThis was a double-blind randomized control study to evaluate the efficacy of cervical priming by nitric oxide donor before second-trimester induced abortion. One-hundred healthy women with a singleton pregnancy between 14 and 20 weeks of gestation were randomized into either 40 mg isosorbide mononitrate or placebo, given intravaginally 12 h before induction. This was followed by intravaginal misoprostol induction. The induction-abortion interval, abortion rate, side effects and the woman's acceptability of the priming agent were recorded. All women completed the study and there was no severe complication recorded. There was no significant difference in the induction-abortion interval and abortion rate between the two groups. Isosorbide mononitrate group reported significantly more side effects of headache. More than 90% of the women in both groups found the priming agent acceptable. The application of intravaginal nitric oxide donors prior to the prostaglandins induction did not significantly improve the second-trimester induced-abortion process. © 2003 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/contraceptionen_HK
dc.relation.ispartofContraceptionen_HK
dc.rightsContraception. Copyright © Elsevier Inc.en_HK
dc.subjectCervical primingen_HK
dc.subjectNitric oxide donoren_HK
dc.subjectSecond-trimester induced abortionen_HK
dc.titleA study of the efficacy of cervical ripening with nitric oxide donor versus placebo for cervical priming before second-trimester termination of pregnancyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0010-7824&volume=68&spage=269&epage=272&date=2003&atitle=A+study+of+the+efficacy+of+cervical+ripening+with+nitric+oxide+donor+versus+placebo+for+cervical+priming+before+second-trimester+termination+of+pregnancyen_HK
dc.identifier.emailHo, PC:pcho@hku.hken_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0010-7824(03)00170-7en_HK
dc.identifier.pmid14572890-
dc.identifier.scopuseid_2-s2.0-0142157542en_HK
dc.identifier.hkuros87491en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0142157542&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume68en_HK
dc.identifier.issue4en_HK
dc.identifier.spage269en_HK
dc.identifier.epage272en_HK
dc.identifier.isiWOS:000186154300007-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLi, CFI=7501686453en_HK
dc.identifier.scopusauthoridChan, CWC=7404813871en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK

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