Article: Passive smoking and tuberculosis

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TitlePassive smoking and tuberculosis
AuthorsLeung, CC1
Lam, TH2
Ho, KS3
Yew, WW4
Tam, CM1
Chan, WM3
Law, WS1
Chan, CK1
Chang, KC1
Au, KF1
Issue Date2010
PublisherAmerican Medical Association. The Journal's web site is located at http://www.archinternmed.com
CitationArchives Of Internal Medicine, 2010, v. 170 n. 3, p. 287-292 [How to Cite?]
DOI: http://dx.doi.org/10.1001/archinternmed.2009.506
AbstractBackground: Increasing evidence has incriminated active smoking as a causal factor for tuberculosis (TB). However, the effect of secondhand tobacco smoke exposure on TB has not been similarly elucidated. Methods: A cohort of 15 486 female never-smokers aged 65 to 74 years and living with their surviving husband were enrolled at 18 Elderly Health Centers in Hong Kong from 2000 to 2003 and followed up prospectively through linkage with the territory-wide TB notification registry and death registry for TB and death until December 31, 2008, using an identity card number as a unique identifier. The relationship between passive smoking and the development of TB was assessed with adjustment for other baseline characteristics. Results: Passive exposure to secondhand tobacco smoke in the household was independently associated with obstructive lung disease (odds [OR], 1.43; 95% confidence interval [CI], 1.16-1.77) and diabetes mellitus (OR, 1.13; 95% CI, 1.02-1.26) at baseline and with the development of both active TB (hazard ratio [HR], 1.49; 95% CI, 1.01-2.19) and culture-confirmed TB (HR, 1.70; 95% CI, 1.04-2.80) on prospective follow-up after potentially confounding background variables were controlled for. Passive smoking accounted for 13.7% of active TB and for 18.5% of culture-positive TB in this cohort. Conclusions: Similar to active smoking, passive exposure to secondhand tobacco smoke in the household also predisposes to the development of TB. Increased emphasis should therefore be put on tobacco control in national TB programs. ©2010 American Medical Association. All rights reserved.
ISSN0003-9926
2011 Impact Factor: 11.462
2011 SCImago Journal Rankings: 1.049
DOIhttp://dx.doi.org/10.1001/archinternmed.2009.506
ISI Accession Number IDWOS:000274291100011
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLeung, CC
dc.contributor.authorLam, TH
dc.contributor.authorHo, KS
dc.contributor.authorYew, WW
dc.contributor.authorTam, CM
dc.contributor.authorChan, WM
dc.contributor.authorLaw, WS
dc.contributor.authorChan, CK
dc.contributor.authorChang, KC
dc.contributor.authorAu, KF
dc.date.accessioned2010-09-06T09:23:55Z
dc.date.available2010-09-06T09:23:55Z
dc.date.issued2010
dc.description.abstractBackground: Increasing evidence has incriminated active smoking as a causal factor for tuberculosis (TB). However, the effect of secondhand tobacco smoke exposure on TB has not been similarly elucidated. Methods: A cohort of 15 486 female never-smokers aged 65 to 74 years and living with their surviving husband were enrolled at 18 Elderly Health Centers in Hong Kong from 2000 to 2003 and followed up prospectively through linkage with the territory-wide TB notification registry and death registry for TB and death until December 31, 2008, using an identity card number as a unique identifier. The relationship between passive smoking and the development of TB was assessed with adjustment for other baseline characteristics. Results: Passive exposure to secondhand tobacco smoke in the household was independently associated with obstructive lung disease (odds [OR], 1.43; 95% confidence interval [CI], 1.16-1.77) and diabetes mellitus (OR, 1.13; 95% CI, 1.02-1.26) at baseline and with the development of both active TB (hazard ratio [HR], 1.49; 95% CI, 1.01-2.19) and culture-confirmed TB (HR, 1.70; 95% CI, 1.04-2.80) on prospective follow-up after potentially confounding background variables were controlled for. Passive smoking accounted for 13.7% of active TB and for 18.5% of culture-positive TB in this cohort. Conclusions: Similar to active smoking, passive exposure to secondhand tobacco smoke in the household also predisposes to the development of TB. Increased emphasis should therefore be put on tobacco control in national TB programs. ©2010 American Medical Association. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationArchives Of Internal Medicine, 2010, v. 170 n. 3, p. 287-292 [How to Cite?]
DOI: http://dx.doi.org/10.1001/archinternmed.2009.506
dc.identifier.citeulike6668272
dc.identifier.doihttp://dx.doi.org/10.1001/archinternmed.2009.506
dc.identifier.epage292
dc.identifier.hkuros168860
dc.identifier.isiWOS:000274291100011
dc.identifier.issn0003-9926
2011 Impact Factor: 11.462
2011 SCImago Journal Rankings: 1.049
dc.identifier.issue3
dc.identifier.openurl
dc.identifier.pmid20142576
dc.identifier.scopuseid_2-s2.0-76149121478
dc.identifier.spage287
dc.identifier.urihttp://hdl.handle.net/10722/86999
dc.identifier.volume170
dc.languageeng
dc.publisherAmerican Medical Association. The Journal's web site is located at http://www.archinternmed.com
dc.publisher.placeUnited States
dc.relation.ispartofArchives of Internal Medicine
dc.relation.referencesReferences in Scopus
dc.subject.meshAged
dc.subject.meshConfidence Intervals
dc.subject.meshFemale
dc.subject.meshFollow-Up Studies
dc.subject.meshHong Kong - epidemiology
dc.subject.meshHumans
dc.subject.meshIncidence
dc.subject.meshPrognosis
dc.subject.meshProportional Hazards Models
dc.subject.meshRetrospective Studies
dc.subject.meshRisk Factors
dc.subject.meshTobacco Smoke Pollution - adverse effects
dc.subject.meshTuberculosis - epidemiology - etiology
dc.titlePassive smoking and tuberculosis
dc.typeArticle
Author Affiliations
  1. Tuberculosis and Chest Service
  2. The University of Hong Kong
  3. Hong Kong Government
  4. Grantham Hospital Hong Kong