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Article: A study on lymphocyte DNA damage in traffic policemen in Guangzhou

TitleA study on lymphocyte DNA damage in traffic policemen in Guangzhou
Authors
Issue Date2003
PublisherZhonghua Laodong Weisheng Zhiyebing Zazhi. The Journal's web site is located at http://zhldwszyb.periodicals.net.cn/default.html
Citation
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi = Zhonghua Laodong Weisheng Zhiyebing Zazhi = Chinese Journal Of Industrial Hygiene And Occupational Diseases, 2003, v. 21 n. 1, p. 41-44 How to Cite?
AbstractOBJECTIVE: To study the effect of occupational exposure to traffic exhaust and smoking on DNA damage in traffic policemen. METHODS: 812 traffic policemen (741 men and 71 women, 130 of office-work and 682 of outside work) from 8 districts in Guangzhou were investigated. Blood samples were taken by venipuncture and lymphocytes were collected by using lymphocyte separation medium and centrifugation. The comet assay was used to measure DNA damage. RESULTS: The office-work policemen [(37.7 +/- 9.5) years] were older than the outside-work ones [(32.3 +/- 8.1) years, P < 0.001]. No significant difference was observed in sex (P = 0.08) and age (P = 0.45). Comet assay showed that occupational exposure to traffic exhaust significantly increased tail length [4.20 micro m, 95% CI: (3.98 - 4.42) micro m vs 3.23 micro m, 95% CI: (2.82 - 3.7) micro m, P < 0.001]. Smokers had longer tail length [4.66 micro m, 95% CI: (4.37 - 4.97) micro m] than ex-smokers [3.28 micro m, 95% CI: (2.57 - 4.17) micro m] and nonsmokers [3.47 micro m, 95% CI: (3.21 - 3.75) micro m, P < 0.001]. In nonsmokers, significant increase in tail length was observed by passive smoking at home (P = 0.004) but not at work (P = 0.22). When out-door nonsmokers were excluded, passive smoking at work also significantly increased tail length (P = 0.007). Analysis of covariance showed that occupational exposure to traffic exhaust, tobacco smoking, and female had independent effect on lymphocyte DNA damage (P < 0.001) after these factors were adjusted. Passive smoking and age had no effect on lymphocyte DNA damage. CONCLUSIONS: Occupational exposure to traffic exhaust and tobacco smoking respectively increase lymphocyte DNA damage. Female traffic policemen may have more severe DNA damage than male.
Persistent Identifierhttp://hdl.handle.net/10722/86970
ISSN
2015 SCImago Journal Rankings: 0.117

 

DC FieldValueLanguage
dc.contributor.authorZhu, CQen_HK
dc.contributor.authorLam, Ten_HK
dc.contributor.authorJiang, CQen_HK
dc.contributor.authorWei, BXen_HK
dc.contributor.authorChen, YHen_HK
dc.contributor.authorXu, QRen_HK
dc.date.accessioned2010-09-06T09:23:34Z-
dc.date.available2010-09-06T09:23:34Z-
dc.date.issued2003en_HK
dc.identifier.citationZhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi = Zhonghua Laodong Weisheng Zhiyebing Zazhi = Chinese Journal Of Industrial Hygiene And Occupational Diseases, 2003, v. 21 n. 1, p. 41-44en_HK
dc.identifier.issn1001-9391en_HK
dc.identifier.urihttp://hdl.handle.net/10722/86970-
dc.description.abstractOBJECTIVE: To study the effect of occupational exposure to traffic exhaust and smoking on DNA damage in traffic policemen. METHODS: 812 traffic policemen (741 men and 71 women, 130 of office-work and 682 of outside work) from 8 districts in Guangzhou were investigated. Blood samples were taken by venipuncture and lymphocytes were collected by using lymphocyte separation medium and centrifugation. The comet assay was used to measure DNA damage. RESULTS: The office-work policemen [(37.7 +/- 9.5) years] were older than the outside-work ones [(32.3 +/- 8.1) years, P < 0.001]. No significant difference was observed in sex (P = 0.08) and age (P = 0.45). Comet assay showed that occupational exposure to traffic exhaust significantly increased tail length [4.20 micro m, 95% CI: (3.98 - 4.42) micro m vs 3.23 micro m, 95% CI: (2.82 - 3.7) micro m, P < 0.001]. Smokers had longer tail length [4.66 micro m, 95% CI: (4.37 - 4.97) micro m] than ex-smokers [3.28 micro m, 95% CI: (2.57 - 4.17) micro m] and nonsmokers [3.47 micro m, 95% CI: (3.21 - 3.75) micro m, P < 0.001]. In nonsmokers, significant increase in tail length was observed by passive smoking at home (P = 0.004) but not at work (P = 0.22). When out-door nonsmokers were excluded, passive smoking at work also significantly increased tail length (P = 0.007). Analysis of covariance showed that occupational exposure to traffic exhaust, tobacco smoking, and female had independent effect on lymphocyte DNA damage (P < 0.001) after these factors were adjusted. Passive smoking and age had no effect on lymphocyte DNA damage. CONCLUSIONS: Occupational exposure to traffic exhaust and tobacco smoking respectively increase lymphocyte DNA damage. Female traffic policemen may have more severe DNA damage than male.en_HK
dc.languageengen_HK
dc.publisherZhonghua Laodong Weisheng Zhiyebing Zazhi. The Journal's web site is located at http://zhldwszyb.periodicals.net.cn/default.htmlen_HK
dc.relation.ispartofZhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseasesen_HK
dc.subject.meshDNA Damage-
dc.subject.meshLymphocytes - metabolism-
dc.subject.meshOccupational Exposure-
dc.subject.meshPolice-
dc.subject.meshVehicle Emissions - adverse effects-
dc.titleA study on lymphocyte DNA damage in traffic policemen in Guangzhouen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1001-9391&volume=21&issue=1&spage=41&epage=44&date=2003&atitle=A+study+on+lymphocyte+DNA+damage+in+traffic+policemen+in+Guangzhou+(Chinese)-
dc.identifier.emailLam, T:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, T=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid14761571-
dc.identifier.scopuseid_2-s2.0-1842459457en_HK
dc.identifier.hkuros96687en_HK
dc.identifier.volume21en_HK
dc.identifier.issue1en_HK
dc.identifier.spage41en_HK
dc.identifier.epage44en_HK
dc.publisher.placeChinaen_HK
dc.identifier.scopusauthoridZhu, CQ=8537385600en_HK
dc.identifier.scopusauthoridLam, T=7202522876en_HK
dc.identifier.scopusauthoridJiang, CQ=10639500500en_HK
dc.identifier.scopusauthoridWei, BX=7202263700en_HK
dc.identifier.scopusauthoridChen, YH=8138124300en_HK
dc.identifier.scopusauthoridXu, QR=7403743673en_HK

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