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Article: Lymphocyte DNA damage in elevator manufacturing workers in Guangzhou, China

TitleLymphocyte DNA damage in elevator manufacturing workers in Guangzhou, China
Authors
Issue Date2002
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/gentox
Citation
Mutation Research - Genetic Toxicology And Environmental Mutagenesis, 2002, v. 515 n. 1-2, p. 147-157 How to Cite?
AbstractAims: To study the effect of smoking, passive smoking, alcohol drinking, and occupational exposure to low level of benzene on DNA strand breaks in elevator manufacturing workers in Guangzhou, China. Methods: Three hundred and fifty-nine workers (252 men and 107 women) of a modern elevator manufacturing factory, 205 were from production departments and 154 from managerial department. Information on the workers' health conditions, smoking, passive smoking, alcohol consumption and occupational exposure history was collected by personal interview. Lymphocyte DNA damage was measured by the Comet assay. Results: None of the women smoked and 20.6% of the men were daily smokers. In non-smokers, the prevalence of passive smoking at work was 25% for men and 11.2% for women, and at home, 37.8 and 48.6%, respectively. Smoking significantly increased tail moment (P<0.001). Daily smokers had the largest tail moment (geometric mean, 95% CI) (0.93μm (0.81-0.94)), followed by occasional smokers (0.76μm (0.59-0.95)), ex-smokers (0.70μm (0.58-0.85)), and never smokers (0.56μm (0.53-0.60)). Tail moment increased significantly with daily tobacco consumption (cigarettes per day) (r=0.26, P<0.001) after adjusting for age, gender, occupational exposure, passive smoking, and drinking. Analysis of covariance (ANCOVA) showed that smoking (P<0.001), passive smoking at home (P=0.026), occupational exposure (P<0.001), male gender (P<0.001), and age (P=0.001) had independent effects on tail moment, whereas passive smoking at work and alcohol drinking had no significant effect. Conclusions: Smoking, passive smoking at home, male gender, age and occupational exposure independently increased lymphocyte DNA strand breaks. The presence of excess DNA damage under low level of occupational exposure to benzene or other solvents suggest that the current allowance concentrations may not be safe to prevent genotoxicity. © 2002 Elsevier Science B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/86941
ISSN
2015 Impact Factor: 2.254
2015 SCImago Journal Rankings: 1.052
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, THen_HK
dc.contributor.authorZhu, CQen_HK
dc.contributor.authorJiang, CQen_HK
dc.date.accessioned2010-09-06T09:23:13Z-
dc.date.available2010-09-06T09:23:13Z-
dc.date.issued2002en_HK
dc.identifier.citationMutation Research - Genetic Toxicology And Environmental Mutagenesis, 2002, v. 515 n. 1-2, p. 147-157en_HK
dc.identifier.issn1383-5718en_HK
dc.identifier.urihttp://hdl.handle.net/10722/86941-
dc.description.abstractAims: To study the effect of smoking, passive smoking, alcohol drinking, and occupational exposure to low level of benzene on DNA strand breaks in elevator manufacturing workers in Guangzhou, China. Methods: Three hundred and fifty-nine workers (252 men and 107 women) of a modern elevator manufacturing factory, 205 were from production departments and 154 from managerial department. Information on the workers' health conditions, smoking, passive smoking, alcohol consumption and occupational exposure history was collected by personal interview. Lymphocyte DNA damage was measured by the Comet assay. Results: None of the women smoked and 20.6% of the men were daily smokers. In non-smokers, the prevalence of passive smoking at work was 25% for men and 11.2% for women, and at home, 37.8 and 48.6%, respectively. Smoking significantly increased tail moment (P<0.001). Daily smokers had the largest tail moment (geometric mean, 95% CI) (0.93μm (0.81-0.94)), followed by occasional smokers (0.76μm (0.59-0.95)), ex-smokers (0.70μm (0.58-0.85)), and never smokers (0.56μm (0.53-0.60)). Tail moment increased significantly with daily tobacco consumption (cigarettes per day) (r=0.26, P<0.001) after adjusting for age, gender, occupational exposure, passive smoking, and drinking. Analysis of covariance (ANCOVA) showed that smoking (P<0.001), passive smoking at home (P=0.026), occupational exposure (P<0.001), male gender (P<0.001), and age (P=0.001) had independent effects on tail moment, whereas passive smoking at work and alcohol drinking had no significant effect. Conclusions: Smoking, passive smoking at home, male gender, age and occupational exposure independently increased lymphocyte DNA strand breaks. The presence of excess DNA damage under low level of occupational exposure to benzene or other solvents suggest that the current allowance concentrations may not be safe to prevent genotoxicity. © 2002 Elsevier Science B.V. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/gentoxen_HK
dc.relation.ispartofMutation Research - Genetic Toxicology and Environmental Mutagenesisen_HK
dc.rightsMutation Research. Copyright © Elsevier BV.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAge Factorsen_HK
dc.subject.meshAlcohol Drinking - adverse effectsen_HK
dc.subject.meshBenzene - adverse effectsen_HK
dc.subject.meshChinaen_HK
dc.subject.meshComet Assayen_HK
dc.subject.meshDNA - drug effectsen_HK
dc.subject.meshDNA Damage - drug effectsen_HK
dc.subject.meshElevators and Escalatorsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLymphocytes - metabolismen_HK
dc.subject.meshMaleen_HK
dc.subject.meshOccupational Exposure - adverse effectsen_HK
dc.subject.meshSex Factorsen_HK
dc.subject.meshSmoking - adverse effectsen_HK
dc.titleLymphocyte DNA damage in elevator manufacturing workers in Guangzhou, Chinaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0027-5107&volume=515&spage=147&epage=157&date=2002&atitle=Lymphocyte+DNA+damage+in+elevator+manufacturing+workers+in+Guangzhou,+Chinaen_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S1383-5718(02)00010-4en_HK
dc.identifier.pmid11909763-
dc.identifier.scopuseid_2-s2.0-0037170676en_HK
dc.identifier.hkuros65797en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037170676&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume515en_HK
dc.identifier.issue1-2en_HK
dc.identifier.spage147en_HK
dc.identifier.epage157en_HK
dc.identifier.isiWOS:000174691200014-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridZhu, CQ=8537385600en_HK
dc.identifier.scopusauthoridJiang, CQ=10639500500en_HK

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