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Article: Is the timing of exposure to infection a major determinant of acute lymphoblastic leukaemia in Hong Kong?

TitleIs the timing of exposure to infection a major determinant of acute lymphoblastic leukaemia in Hong Kong?
Authors
Issue Date2002
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PPE
Citation
Paediatric And Perinatal Epidemiology, 2002, v. 16 n. 2, p. 154-165 How to Cite?
AbstractThe hypothesis that protection of infants from exposure to infectious agents with delayed first exposure to one or more specific agents together contribute to the aetiology of childhood leukaemia, especially common acute lymphoblastic leukaemia (cALL), has substantial indirect support from descriptive epidemiology and case-control studies in developed Western countries. A case-control study of childhood leukaemia diagnosed at ages 2-14 years has now been conducted in Hong Kong. Cases (n = 98) formed a consecutive series of Chinese children diagnosed with acute leukaemia; controls (n = 228) were identified following a survey using random digit dialling and required to attend for medical examination by a peadiatrician. Interviews with mothers were conducted in hospital by one trained interviewer using a structured questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) are reported for exposure variables capable of serving as proxies for exposure to infection in two critical time periods: first year of life, year before reference date (diagnosis for cases, corresponding date for controls). Analyses used logistic regression with adjustment for appropriate confounders. Change of area of residence reduced risk if during the first time period (OR = 0.47 [95% CI 0.23, 0.98]) and increased risk if during the second (OR = 3.92, [95% CI 1.47, 10.46]). Reported roseola and/or fever and rash in the first year of life reduced risk (OR = 0.33 [95% CI 0.16, 0.68]) whereas tonsillitis in the period 3-12 months before reference date increased risk (OR = 2.56 [95% CI 1.22, 5.38]). Some other proxies for exposure to infection at the critical times were associated with predicted patterns of risk but day-care attendance failed to show predicted associations. These results provide support for the delayed exposure hypothesis in an affluent geographical setting in which population exposure to infectious agents is quite distinct from the settings of previous case-control studies.
Persistent Identifierhttp://hdl.handle.net/10722/86933
ISSN
2015 Impact Factor: 2.958
2015 SCImago Journal Rankings: 5.514
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, LCen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorLi, CKen_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorLi, CKen_HK
dc.contributor.authorYuen, HLen_HK
dc.contributor.authorLee, CWen_HK
dc.contributor.authorHa, SYen_HK
dc.contributor.authorYuen, PMPen_HK
dc.contributor.authorLeung, NKen_HK
dc.contributor.authorPatheal, SLen_HK
dc.contributor.authorGreaves, MFen_HK
dc.contributor.authorAlexander, FEen_HK
dc.date.accessioned2010-09-06T09:23:07Z-
dc.date.available2010-09-06T09:23:07Z-
dc.date.issued2002en_HK
dc.identifier.citationPaediatric And Perinatal Epidemiology, 2002, v. 16 n. 2, p. 154-165en_HK
dc.identifier.issn0269-5022en_HK
dc.identifier.urihttp://hdl.handle.net/10722/86933-
dc.description.abstractThe hypothesis that protection of infants from exposure to infectious agents with delayed first exposure to one or more specific agents together contribute to the aetiology of childhood leukaemia, especially common acute lymphoblastic leukaemia (cALL), has substantial indirect support from descriptive epidemiology and case-control studies in developed Western countries. A case-control study of childhood leukaemia diagnosed at ages 2-14 years has now been conducted in Hong Kong. Cases (n = 98) formed a consecutive series of Chinese children diagnosed with acute leukaemia; controls (n = 228) were identified following a survey using random digit dialling and required to attend for medical examination by a peadiatrician. Interviews with mothers were conducted in hospital by one trained interviewer using a structured questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) are reported for exposure variables capable of serving as proxies for exposure to infection in two critical time periods: first year of life, year before reference date (diagnosis for cases, corresponding date for controls). Analyses used logistic regression with adjustment for appropriate confounders. Change of area of residence reduced risk if during the first time period (OR = 0.47 [95% CI 0.23, 0.98]) and increased risk if during the second (OR = 3.92, [95% CI 1.47, 10.46]). Reported roseola and/or fever and rash in the first year of life reduced risk (OR = 0.33 [95% CI 0.16, 0.68]) whereas tonsillitis in the period 3-12 months before reference date increased risk (OR = 2.56 [95% CI 1.22, 5.38]). Some other proxies for exposure to infection at the critical times were associated with predicted patterns of risk but day-care attendance failed to show predicted associations. These results provide support for the delayed exposure hypothesis in an affluent geographical setting in which population exposure to infectious agents is quite distinct from the settings of previous case-control studies.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/PPEen_HK
dc.relation.ispartofPaediatric and Perinatal Epidemiologyen_HK
dc.rightsPaediatric and Perinatal Epidemiology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAge of Onseten_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshChilden_HK
dc.subject.meshChild, Preschoolen_HK
dc.subject.meshComorbidityen_HK
dc.subject.meshDay Care - statistics & numerical dataen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfection - epidemiologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMultivariate Analysisen_HK
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiologyen_HK
dc.subject.meshResidence Characteristics - statistics & numerical dataen_HK
dc.subject.meshSocial Conditions - statistics & numerical dataen_HK
dc.subject.meshTime Factorsen_HK
dc.titleIs the timing of exposure to infection a major determinant of acute lymphoblastic leukaemia in Hong Kong?en_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0269-5022&volume=16&spage=154&epage=165&date=2002&atitle=Is+the+timing+of+exposure+to+infection+a+major+determinant+of+acute+lymphoblastic+leukaemia+in+Hong+Kong?en_HK
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityChan, LC=rp00373en_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1365-3016.2002.00406.xen_HK
dc.identifier.pmid12060313-
dc.identifier.scopuseid_2-s2.0-0036254345en_HK
dc.identifier.hkuros66120en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036254345&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue2en_HK
dc.identifier.spage154en_HK
dc.identifier.epage165en_HK
dc.identifier.isiWOS:000175542800009-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChan, LC=7403540707en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridLi, CK=15122650100en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridLi, CK=19035337000en_HK
dc.identifier.scopusauthoridYuen, HL=7103253677en_HK
dc.identifier.scopusauthoridLee, CW=19035218500en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.scopusauthoridYuen, PMP=7103124005en_HK
dc.identifier.scopusauthoridLeung, NK=7006841120en_HK
dc.identifier.scopusauthoridPatheal, SL=7801638419en_HK
dc.identifier.scopusauthoridGreaves, MF=35398813200en_HK
dc.identifier.scopusauthoridAlexander, FE=7101861992en_HK

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