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Article: The impact of modifiable risk factors on mortality from prostate cancer in populations of the Asia-Pacific Region

TitleThe impact of modifiable risk factors on mortality from prostate cancer in populations of the Asia-Pacific Region
Authors
Issue Date2007
Citation
Asian Pacific Journal of Cancer Prevention, 2007, v. 8 n. 2, p. 199-205 How to Cite?
AbstractMortality from cancer of the prostate is increasing in the Asia-Pacific, when much of this region is undergoing a transition to a Western lifestyle. The role that lifestyle factors play in prostate cancer appears limited, but existing data mainly are from the West. We conducted an individual participant data analysis of 24 cohort studies involving 320,852 men (83% in Asia). Cox proportional hazard models were used to quantify associations between risk factors and mortality from prostate cancer. There were 308 deaths from prostate cancer (14% in Asia) during 2.1 million person-years of follow-up. The age-adjusted hazard ratio (95% confidence interval; CI) for men with body mass index (BMI) 28 kg/m2 or more, compared with below 25, was 1.55 (1.12 - 2.16); no such significant relationship was found for height or waist circumference. The BMI result was unchanged after adjustment for other variables, was consistent between Asia and Australia/New Zealand (ANZ) and did not differ with age. There was no significant relationship with diabetes, glucose or total cholesterol (p ≥ 0.18). Smoking, alone, showed different effects in the two regions, possibly due to the relative immaturity of the smoking epidemic in Asia. In ANZ, the multiple-adjusted hazard ratio for an extra 5 cigarettes per day was 1.12 (95%CI: 1.03 - 1.22), whereas in Asia it was 0.77 (0.56 - 1.05). Body size is an apparently important determinant of prostate cancer in the Asia-Pacific. Evidence of an adverse effect of smoking is conclusive only in the predominantly Caucasian parts of the region.
Persistent Identifierhttp://hdl.handle.net/10722/86884

 

DC FieldValueLanguage
dc.contributor.authorAnsary-Moghaddam, Aen_HK
dc.contributor.authorHuxley, Ren_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorOhkubo, Ten_HK
dc.contributor.authorFang, Xen_HK
dc.contributor.authorJee, SHen_HK
dc.contributor.authorWoodward, Men_HK
dc.date.accessioned2010-09-06T09:22:31Z-
dc.date.available2010-09-06T09:22:31Z-
dc.date.issued2007en_HK
dc.identifier.citationAsian Pacific Journal of Cancer Prevention, 2007, v. 8 n. 2, p. 199-205en_HK
dc.identifier.urihttp://hdl.handle.net/10722/86884-
dc.description.abstractMortality from cancer of the prostate is increasing in the Asia-Pacific, when much of this region is undergoing a transition to a Western lifestyle. The role that lifestyle factors play in prostate cancer appears limited, but existing data mainly are from the West. We conducted an individual participant data analysis of 24 cohort studies involving 320,852 men (83% in Asia). Cox proportional hazard models were used to quantify associations between risk factors and mortality from prostate cancer. There were 308 deaths from prostate cancer (14% in Asia) during 2.1 million person-years of follow-up. The age-adjusted hazard ratio (95% confidence interval; CI) for men with body mass index (BMI) 28 kg/m2 or more, compared with below 25, was 1.55 (1.12 - 2.16); no such significant relationship was found for height or waist circumference. The BMI result was unchanged after adjustment for other variables, was consistent between Asia and Australia/New Zealand (ANZ) and did not differ with age. There was no significant relationship with diabetes, glucose or total cholesterol (p ≥ 0.18). Smoking, alone, showed different effects in the two regions, possibly due to the relative immaturity of the smoking epidemic in Asia. In ANZ, the multiple-adjusted hazard ratio for an extra 5 cigarettes per day was 1.12 (95%CI: 1.03 - 1.22), whereas in Asia it was 0.77 (0.56 - 1.05). Body size is an apparently important determinant of prostate cancer in the Asia-Pacific. Evidence of an adverse effect of smoking is conclusive only in the predominantly Caucasian parts of the region.-
dc.languageengen_HK
dc.relation.ispartofAsian Pacific Journal of Cancer Preventionen_HK
dc.subject.meshAge Factors-
dc.subject.meshAustralia - epidemiology-
dc.subject.meshFar East - epidemiology-
dc.subject.meshNew Zealand - epidemiology-
dc.subject.meshProstatic Neoplasms - epidemiology - mortality-
dc.titleThe impact of modifiable risk factors on mortality from prostate cancer in populations of the Asia-Pacific Regionen_HK
dc.typeArticleen_HK
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.pmid17696731-
dc.identifier.scopuseid_2-s2.0-40449130549-
dc.identifier.hkuros168792en_HK

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