File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Lymphocyte DNA damage in cigarette factory workers measured by the Comet assay

TitleLymphocyte DNA damage in cigarette factory workers measured by the Comet assay
Authors
Issue Date1999
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/gentox
Citation
Mutation Research - Genetic Toxicology And Environmental Mutagenesis, 1999, v. 444 n. 1, p. 1-6 How to Cite?
AbstractTo investigate whether there were separate and combined effects of occupational exposure to tobacco dust and smoking on lymphocyte DNA damage, 148 workers from a cigarette manufacturing factory (107 occupationally exposed to tobacco dust from the production department and 41 unexposed controls who were managerial workers) were included in the study. The Tail Moment (TM) of Comet assay was used to measure DNA damage. The two groups had similar mean age, mean duration of work and smoking prevalence. The exposed workers had a larger TM than that of the controls (mean±S.D.: 43.43±13.77 vs. 38.89±8.98, p<0.05). Smokers had significantly larger TM than non-smokers (47.25±14.02 vs. 38.90±10.75, p<0.001). Analysis of variance after adjustment for age and gender showed that occupational exposure and smoking had a significant and independent effect on Tail Moment (p=0.025 and p=0.002, respectively) and there was a significant positive two way interaction between the two factors (p=0.019). Age and gender had no significant effect on TM. The present study suggests that smoking and tobacco dust exposure can induce lymphocyte DNA damage and there is a synergistic effect of tobacco dust exposure and smoking on DNA damage. Copyright (C) 1999 Elsevier Science B.V.
Persistent Identifierhttp://hdl.handle.net/10722/86865
ISSN
2015 Impact Factor: 2.254
2015 SCImago Journal Rankings: 1.052
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhu, CQen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorJiang, CQen_HK
dc.contributor.authorWei, BXen_HK
dc.contributor.authorLou, Xen_HK
dc.contributor.authorLiu, WWen_HK
dc.contributor.authorLao, XQen_HK
dc.contributor.authorChen, YHen_HK
dc.date.accessioned2010-09-06T09:22:16Z-
dc.date.available2010-09-06T09:22:16Z-
dc.date.issued1999en_HK
dc.identifier.citationMutation Research - Genetic Toxicology And Environmental Mutagenesis, 1999, v. 444 n. 1, p. 1-6en_HK
dc.identifier.issn1383-5718en_HK
dc.identifier.urihttp://hdl.handle.net/10722/86865-
dc.description.abstractTo investigate whether there were separate and combined effects of occupational exposure to tobacco dust and smoking on lymphocyte DNA damage, 148 workers from a cigarette manufacturing factory (107 occupationally exposed to tobacco dust from the production department and 41 unexposed controls who were managerial workers) were included in the study. The Tail Moment (TM) of Comet assay was used to measure DNA damage. The two groups had similar mean age, mean duration of work and smoking prevalence. The exposed workers had a larger TM than that of the controls (mean±S.D.: 43.43±13.77 vs. 38.89±8.98, p<0.05). Smokers had significantly larger TM than non-smokers (47.25±14.02 vs. 38.90±10.75, p<0.001). Analysis of variance after adjustment for age and gender showed that occupational exposure and smoking had a significant and independent effect on Tail Moment (p=0.025 and p=0.002, respectively) and there was a significant positive two way interaction between the two factors (p=0.019). Age and gender had no significant effect on TM. The present study suggests that smoking and tobacco dust exposure can induce lymphocyte DNA damage and there is a synergistic effect of tobacco dust exposure and smoking on DNA damage. Copyright (C) 1999 Elsevier Science B.V.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/gentoxen_HK
dc.relation.ispartofMutation Research - Genetic Toxicology and Environmental Mutagenesisen_HK
dc.rightsMutation Research. Copyright © Elsevier BV.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshChinaen_HK
dc.subject.meshDNA - analysisen_HK
dc.subject.meshDNA Damageen_HK
dc.subject.meshDust - adverse effectsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLymphocytes - metabolismen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshOccupational Exposureen_HK
dc.subject.meshPlants, Toxicen_HK
dc.subject.meshSmoking - adverse effects - geneticsen_HK
dc.subject.meshTobaccoen_HK
dc.titleLymphocyte DNA damage in cigarette factory workers measured by the Comet assayen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0027-5107&volume=444&spage=1&epage=6&date=1999&atitle=Lymphocyte+DNA+damage+in+cigarette+factory+workers+measured+by+the+Comet+assayen_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S1383-5718(99)00097-2en_HK
dc.identifier.pmid10477334-
dc.identifier.scopuseid_2-s2.0-0032809428en_HK
dc.identifier.hkuros47249en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032809428&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume444en_HK
dc.identifier.issue1en_HK
dc.identifier.spage1en_HK
dc.identifier.epage6en_HK
dc.identifier.isiWOS:000081907800001-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridZhu, CQ=8537385600en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridJiang, CQ=10639500500en_HK
dc.identifier.scopusauthoridWei, BX=8138124100en_HK
dc.identifier.scopusauthoridLou, X=7103370295en_HK
dc.identifier.scopusauthoridLiu, WW=26643405200en_HK
dc.identifier.scopusauthoridLao, XQ=14031637000en_HK
dc.identifier.scopusauthoridChen, YH=8138124300en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats