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Article: Lymphocyte DNA damage in cigarette factory workers measured by comet assay

TitleLymphocyte DNA damage in cigarette factory workers measured by comet assay
職業性低濃度煙草塵接觸對作業工人淋巴細胞DNA的損傷
Authors
Issue Date2001
PublisherZhonghua Laodong Weisheng Zhiyebing Zazhi. The Journal's web site is located at http://zhldwszyb.periodicals.net.cn/default.html
Citation
Chinese Journal of Industrial Hygiene and Occupational Diseases (中華勞動衛生職業病雜誌), 2001, v. 19 n. 5, p. 351-353 How to Cite?
AbstractObjective To investigate whether there were separate and combined effects of occupational exposure to tobacco dust and smoking on lymphocyte DNA damage. Method 148 workers(107 workers occupationally exposed to tobacco dust from the production department and 41 controls who were managerial workers) were included in the study.The tail moment(TM) of comet assay was used to measure DNA damage.The two groups had similar mean age,mean duration of work and smoking prevalence. Results The exposed workers had a larger TM than that of the control(mean± s ):(43.43±13.77)μm vs. (38.89±8.98)μm,( P <0.05).Smoking could significantly increases TM[(47.25±14.02)μm vs. (38.90±10.75)μm, P <0.001].Analysis of variance after adjustment for age and gender showed that occupational exposure and smoking had a significant and independent effect on TM( P =0.025 vs. P =0.002,respectively) and there was a significant positive two way interaction between the two factors( P =0.019).Age and gender had no significant effect on TM. Conclusion Smoking and tobacco dust exposure can induce lymphocyte DNA damage and there is a synergistic effect of tobacco dust exposure and smoking on DNA damage.
Persistent Identifierhttp://hdl.handle.net/10722/86860
ISSN
2015 SCImago Journal Rankings: 0.117

 

DC FieldValueLanguage
dc.contributor.authorLu, Xen_HK
dc.contributor.authorZhu, CQen_HK
dc.contributor.authorWei, BXen_HK
dc.contributor.authorLiu, WWen_HK
dc.contributor.authorLao, Xen_HK
dc.contributor.authorChen, YHen_HK
dc.contributor.authorXu, QRen_HK
dc.contributor.author黨, 衛民zh_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorJiang, CQen_HK
dc.date.accessioned2010-09-06T09:22:13Z-
dc.date.available2010-09-06T09:22:13Z-
dc.date.issued2001en_HK
dc.identifier.citationChinese Journal of Industrial Hygiene and Occupational Diseases (中華勞動衛生職業病雜誌), 2001, v. 19 n. 5, p. 351-353en_HK
dc.identifier.issn1001-9391-
dc.identifier.urihttp://hdl.handle.net/10722/86860-
dc.description.abstractObjective To investigate whether there were separate and combined effects of occupational exposure to tobacco dust and smoking on lymphocyte DNA damage. Method 148 workers(107 workers occupationally exposed to tobacco dust from the production department and 41 controls who were managerial workers) were included in the study.The tail moment(TM) of comet assay was used to measure DNA damage.The two groups had similar mean age,mean duration of work and smoking prevalence. Results The exposed workers had a larger TM than that of the control(mean± s ):(43.43±13.77)μm vs. (38.89±8.98)μm,( P <0.05).Smoking could significantly increases TM[(47.25±14.02)μm vs. (38.90±10.75)μm, P <0.001].Analysis of variance after adjustment for age and gender showed that occupational exposure and smoking had a significant and independent effect on TM( P =0.025 vs. P =0.002,respectively) and there was a significant positive two way interaction between the two factors( P =0.019).Age and gender had no significant effect on TM. Conclusion Smoking and tobacco dust exposure can induce lymphocyte DNA damage and there is a synergistic effect of tobacco dust exposure and smoking on DNA damage.-
dc.languagechien_HK
dc.publisherZhonghua Laodong Weisheng Zhiyebing Zazhi. The Journal's web site is located at http://zhldwszyb.periodicals.net.cn/default.html-
dc.relation.ispartofChinese Journal of Industrial Hygiene and Occupational Diseases (中華勞動衛生職業病雜誌)en_HK
dc.titleLymphocyte DNA damage in cigarette factory workers measured by comet assayen_HK
dc.title職業性低濃度煙草塵接觸對作業工人淋巴細胞DNA的損傷-
dc.typeArticleen_HK
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hken_HK
dc.identifier.emailJiang, CQ: cqjiang@HKUCC.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.identifier.doi10.3760/cma.j.issn.1001-9391.2001.05.010-
dc.identifier.hkuros96541en_HK

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