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Article: Systolic blood pressure, diabetes and the risk of cardiovascular diseases in the Asia-Pacific region

TitleSystolic blood pressure, diabetes and the risk of cardiovascular diseases in the Asia-Pacific region
Authors
Issue Date2007
PublisherLippincott Williams & Wilkins, Ltd. The Journal's web site is located at http://www.jhypertension.com/
Citation
Journal Of Hypertension, 2007, v. 25 n. 6, p. 1205-1213 How to Cite?
AbstractOBJECTIVE: To assess the association between systolic blood pressure (SBP) and cardiovascular diseases (CVD) among participants with and without diabetes from cohorts in the Asia-Pacific region. RESEARCH DESIGN AND METHODS: Hazards ratios and 95% confidence intervals (CI) for CVD were calculated from Cox models, stratified by sex and region and adjusted for age using individual participant data from 36 cohort studies. Repeat measurements of SBP were used to adjust for regression dilution bias. RESULTS: During follow-up, 7387 fatal or non-fatal cardiovascular endpoints were recorded among 368 307 participants (6.4% with diabetes). SBP was associated with coronary heart disease (CHD), ischaemic stroke and haemorrhagic stroke in a continuous log-linear fashion among individuals with diabetes, as well as those without diabetes. Overall, each 10 mmHg higher usual SBP was associated with 18% (95% CI: 9-27%) and 23% (19-26%) greater risk for CHD among those with and without diabetes, respectively. The corresponding values for ischaemic stroke were 29% (14-45%) and 43% (37-50%), and for haemorrhagic stroke, 56% (32-83%) and 74% (66-82%). The test for heterogeneity by diabetes status in each of these associations was not significant (P ≥ 0.10). CONCLUSIONS: Systolic blood pressure is an important marker of risk of CVD in people with and without diabetes. A given reduction in systolic blood pressure is likely to have a similar relative effect on reducing the risk of a cardiovascular event, regardless of diabetes status. © 2007 Lippincott Williams & Wilkins, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/86827
ISSN
2015 Impact Factor: 5.062
2015 SCImago Journal Rankings: 2.193
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorKengne, APen_HK
dc.contributor.authorPatel, Aen_HK
dc.contributor.authorBarzi, Fen_HK
dc.contributor.authorJamrozik, Ken_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorUeshima, Hen_HK
dc.contributor.authorGu, DFen_HK
dc.contributor.authorSuh, Ien_HK
dc.contributor.authorWoodward, Men_HK
dc.date.accessioned2010-09-06T09:21:48Z-
dc.date.available2010-09-06T09:21:48Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Hypertension, 2007, v. 25 n. 6, p. 1205-1213en_HK
dc.identifier.issn0263-6352en_HK
dc.identifier.urihttp://hdl.handle.net/10722/86827-
dc.description.abstractOBJECTIVE: To assess the association between systolic blood pressure (SBP) and cardiovascular diseases (CVD) among participants with and without diabetes from cohorts in the Asia-Pacific region. RESEARCH DESIGN AND METHODS: Hazards ratios and 95% confidence intervals (CI) for CVD were calculated from Cox models, stratified by sex and region and adjusted for age using individual participant data from 36 cohort studies. Repeat measurements of SBP were used to adjust for regression dilution bias. RESULTS: During follow-up, 7387 fatal or non-fatal cardiovascular endpoints were recorded among 368 307 participants (6.4% with diabetes). SBP was associated with coronary heart disease (CHD), ischaemic stroke and haemorrhagic stroke in a continuous log-linear fashion among individuals with diabetes, as well as those without diabetes. Overall, each 10 mmHg higher usual SBP was associated with 18% (95% CI: 9-27%) and 23% (19-26%) greater risk for CHD among those with and without diabetes, respectively. The corresponding values for ischaemic stroke were 29% (14-45%) and 43% (37-50%), and for haemorrhagic stroke, 56% (32-83%) and 74% (66-82%). The test for heterogeneity by diabetes status in each of these associations was not significant (P ≥ 0.10). CONCLUSIONS: Systolic blood pressure is an important marker of risk of CVD in people with and without diabetes. A given reduction in systolic blood pressure is likely to have a similar relative effect on reducing the risk of a cardiovascular event, regardless of diabetes status. © 2007 Lippincott Williams & Wilkins, Inc.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins, Ltd. The Journal's web site is located at http://www.jhypertension.com/en_HK
dc.relation.ispartofJournal of Hypertensionen_HK
dc.rightsJournal of hypertension. Copyright © Lippincott Williams & Wilkins, Ltd.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAsian Continental Ancestry Group - statistics & numerical dataen_HK
dc.subject.meshAustralia - epidemiologyen_HK
dc.subject.meshBlood Pressure - physiologyen_HK
dc.subject.meshCardiovascular Diseases - epidemiology - mortalityen_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshDiabetes Mellitus - epidemiologyen_HK
dc.subject.meshEuropean Continental Ancestry Group - statistics & numerical dataen_HK
dc.subject.meshHumansen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshStroke - epidemiology - mortalityen_HK
dc.subject.meshSurvival Analysisen_HK
dc.subject.meshSystole - physiologyen_HK
dc.titleSystolic blood pressure, diabetes and the risk of cardiovascular diseases in the Asia-Pacific regionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0263-6352&volume=25&spage=1205&epage=1213&date=2007&atitle=Systolic+blood+pressure,+diabetes+and+the+risk+of+cardiovascular+diseases+in+the+Asia-Pacific+regionen_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/HJH.0b013e3280dce59een_HK
dc.identifier.pmid17563533-
dc.identifier.scopuseid_2-s2.0-34250363054en_HK
dc.identifier.hkuros130813en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34250363054&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1205en_HK
dc.identifier.epage1213en_HK
dc.identifier.isiWOS:000247375600007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridKengne, AP=7801322838en_HK
dc.identifier.scopusauthoridPatel, A=7403524909en_HK
dc.identifier.scopusauthoridBarzi, F=7003545543en_HK
dc.identifier.scopusauthoridJamrozik, K=26426193300en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridUeshima, H=7005129002en_HK
dc.identifier.scopusauthoridGu, DF=7202151958en_HK
dc.identifier.scopusauthoridSuh, I=7101988200en_HK
dc.identifier.scopusauthoridWoodward, M=7102510958en_HK

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