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Article: Effects of oseltamivir treatment on duration of clinical illness and viral shedding and household transmission of influenza virus

TitleEffects of oseltamivir treatment on duration of clinical illness and viral shedding and household transmission of influenza virus
Authors
Issue Date2010
PublisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/
Citation
Clinical Infectious Diseases, 2010, v. 50 n. 5, p. 707-714 How to Cite?
AbstractBackground. Large clinical trials have demonstrated the therapeutic efficacy of oseltamivir against influenza. We assessed the indirect effectiveness of oseltamivir in reducing secondary household transmission in an incident cohort of influenza index patients and their household members. Methods. We recruited index outpatients whose rapid test results were positive for influenza from February through September 2007 and January through September 2008. Household contacts were followed up for 7-10 days during 3-4 home visits to monitor symptoms. Nose and throat swabs were collected and tested for influenza by reverse-transcription polymerase chain reaction or viral culture. Results. We followed up 384 index patients and their household contacts. Index patients who took oseltamivir within 24 h of symptom onset halved the time to symptom alleviation (adjusted acceleration factor, 0.56; 95% confidence interval [CI], 0.42-0.76). Oseltamivir treatment was not associated with statistically significant reduction in the duration of viral shedding. Household contacts of index patients who had taken oseltamivir within 24 h of onset had a nonstatistically significant lower risk of developing laboratory-confirmed infection (adjusted odds ratio, 0.54; 95% CI, 0.11-2.57) and a marginally statistically significant lower risk of clinical illness (adjusted odds ratio, 0.52; 95% CI, 0.25-1.08) compared with contacts of index patients who did not take oseltamivir. Conclusions. Oseltamivir treatment is effective in reducing the duration of symptoms, but evidence of household reduction in transmission of influenza virus was inconclusive. © 2010 by the Infectious Diseases Society of America. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/86785
ISSN
2015 Impact Factor: 8.736
2015 SCImago Journal Rankings: 4.742
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Centers for Disease Control and Prevention1 U01 CI000439-02
Government of the Hong Kong SAR08070632
US National Institutes of Health5 U01 GM076497
Hong Kong University Grants CommitteeAoE/M-12/06
Funding Information:

Financial support. This work received financial support from the Centers for Disease Control and Prevention (grant 1 U01 CI000439-02), the Research Fund for the Control of Infectious Disease, Food and Health Bureau, Government of the Hong Kong SAR (grant 08070632), US National Institutes of Health (cooperative agreement 5 U01 GM076497, Models of Infectious Disease Agent Study), and the Area of Excellence Scheme of the Hong Kong University Grants Committee (grant AoE/M-12/06).

References
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DC FieldValueLanguage
dc.contributor.authorNg, Sen_HK
dc.contributor.authorCowling, BJen_HK
dc.contributor.authorFang, VJen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorIp, DKMen_HK
dc.contributor.authorCheng, CKYen_HK
dc.contributor.authorUyeki, TMen_HK
dc.contributor.authorHouck, PMen_HK
dc.contributor.authorMalik Peiris, JSen_HK
dc.contributor.authorLeung, GMen_HK
dc.date.accessioned2010-09-06T09:21:17Z-
dc.date.available2010-09-06T09:21:17Z-
dc.date.issued2010en_HK
dc.identifier.citationClinical Infectious Diseases, 2010, v. 50 n. 5, p. 707-714en_HK
dc.identifier.issn1058-4838en_HK
dc.identifier.urihttp://hdl.handle.net/10722/86785-
dc.description.abstractBackground. Large clinical trials have demonstrated the therapeutic efficacy of oseltamivir against influenza. We assessed the indirect effectiveness of oseltamivir in reducing secondary household transmission in an incident cohort of influenza index patients and their household members. Methods. We recruited index outpatients whose rapid test results were positive for influenza from February through September 2007 and January through September 2008. Household contacts were followed up for 7-10 days during 3-4 home visits to monitor symptoms. Nose and throat swabs were collected and tested for influenza by reverse-transcription polymerase chain reaction or viral culture. Results. We followed up 384 index patients and their household contacts. Index patients who took oseltamivir within 24 h of symptom onset halved the time to symptom alleviation (adjusted acceleration factor, 0.56; 95% confidence interval [CI], 0.42-0.76). Oseltamivir treatment was not associated with statistically significant reduction in the duration of viral shedding. Household contacts of index patients who had taken oseltamivir within 24 h of onset had a nonstatistically significant lower risk of developing laboratory-confirmed infection (adjusted odds ratio, 0.54; 95% CI, 0.11-2.57) and a marginally statistically significant lower risk of clinical illness (adjusted odds ratio, 0.52; 95% CI, 0.25-1.08) compared with contacts of index patients who did not take oseltamivir. Conclusions. Oseltamivir treatment is effective in reducing the duration of symptoms, but evidence of household reduction in transmission of influenza virus was inconclusive. © 2010 by the Infectious Diseases Society of America. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/en_HK
dc.relation.ispartofClinical Infectious Diseasesen_HK
dc.rightsClinical Infectious Diseases. Copyright © University of Chicago Press.en_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAntiviral Agents - therapeutic useen_HK
dc.subject.meshChilden_HK
dc.subject.meshChild, Preschoolen_HK
dc.subject.meshFamily Characteristicsen_HK
dc.subject.meshFamily Healthen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInfanten_HK
dc.subject.meshInfluenza, Human - drug therapy - transmission - virologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshNose - virologyen_HK
dc.subject.meshOrthomyxoviridae - isolation & purificationen_HK
dc.subject.meshOseltamivir - therapeutic useen_HK
dc.subject.meshPharynx - virologyen_HK
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_HK
dc.subject.meshTime Factorsen_HK
dc.subject.meshTreatment Outcomeen_HK
dc.subject.meshVirus Sheddingen_HK
dc.subject.meshYoung Adulten_HK
dc.titleEffects of oseltamivir treatment on duration of clinical illness and viral shedding and household transmission of influenza virusen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1058-4838&volume=50&issue=5&spage=707&epage=714&date=2010&atitle=Effects+of+oseltamivir+treatment+on+duration+of+clinical+illness+and+viral+shedding+and+household+transmission+of+influenza+virusen_HK
dc.identifier.emailCowling, BJ: bcowling@hku.hken_HK
dc.identifier.emailIp, DKM: dkmip@hku.hken_HK
dc.identifier.emailMalik Peiris, JS: malik@hkucc.hku.hken_HK
dc.identifier.emailLeung, GM: gmleung@hku.hken_HK
dc.identifier.authorityCowling, BJ=rp01326en_HK
dc.identifier.authorityIp, DKM=rp00256en_HK
dc.identifier.authorityMalik Peiris, JS=rp00410en_HK
dc.identifier.authorityLeung, GM=rp00460en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1086/650458en_HK
dc.identifier.pmid20121573-
dc.identifier.pmcidPMC2840043-
dc.identifier.scopuseid_2-s2.0-76749102845en_HK
dc.identifier.hkuros168863en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-76749102845&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume50en_HK
dc.identifier.issue5en_HK
dc.identifier.spage707en_HK
dc.identifier.epage714en_HK
dc.identifier.eissn1058-4838-
dc.identifier.isiWOS:000274329400009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.f10002248969-
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.relation.projectViral shedding, natural clinical history and transmissibility of influenza-
dc.identifier.scopusauthoridNg, S=34977173400en_HK
dc.identifier.scopusauthoridCowling, BJ=8644765500en_HK
dc.identifier.scopusauthoridFang, VJ=24474130400en_HK
dc.identifier.scopusauthoridChan, KH=7406034307en_HK
dc.identifier.scopusauthoridIp, DKM=35117701600en_HK
dc.identifier.scopusauthoridCheng, CKY=24474272100en_HK
dc.identifier.scopusauthoridUyeki, TM=6603544967en_HK
dc.identifier.scopusauthoridHouck, PM=7004317844en_HK
dc.identifier.scopusauthoridMalik Peiris, JS=7005486823en_HK
dc.identifier.scopusauthoridLeung, GM=7007159841en_HK
dc.identifier.citeulike6633753-

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