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Article: Risk of upper aerodigestive tract cancer associated with smoking with and without concurrent alcohol consumption

TitleRisk of upper aerodigestive tract cancer associated with smoking with and without concurrent alcohol consumption
Authors
Issue Date2009
PublisherJohn Wiley & Sons, Inc.
Citation
Mount Sinai Journal Of Medicine, 2009, v. 76 n. 4, p. 392-403 How to Cite?
AbstractBackground: Smoking and alcohol are major causal factors for upper aerodigestive tract cancer, but reliable quantification of the combined impact of smoking and alcohol on this cancer and its major subtypes has not been performed. Methods: A meta-analysis of studies that had published quantitative estimates of smoking and upper aerodigestive tract cancer by January 2007 was performed. Pooled estimates of relative risks were obtained. Publication bias was investigated through funnel plots and corrected if found to be present. Results: Overall, 85 studies with information on 53,940 individuals with upper aerodigestive tract cancer were included. The pooled estimate for the association between smoking and the risk of this cancer was 3.47 (95% confidence interval, 3.06-3.92). The risk remained elevated for a decade after smoking cessation but declined thereafter. Individuals who both smoked and consumed alcohol had double the risk of upper aerodigestive tract cancer in comparison with those who only smoked: the relative risk was 6.93 (95% confidence interval, 4.99-9.62) for the former and 2.56 (95% confidence interval, 2.20-2.97) for the latter (P < 0.001). Conclusions: Public health interventions that simultaneously discourage smoking and heavy drinking would have greater benefits than would be expected from those that target only one of these risk factors. © 2009 Mount Sinai School of Medicine.
Persistent Identifierhttp://hdl.handle.net/10722/86735
ISSN
2014 Impact Factor: 1.623
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAnsaryMoghaddam, Aen_HK
dc.contributor.authorHuxley, RRen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorWoodward, Men_HK
dc.date.accessioned2010-09-06T09:20:41Z-
dc.date.available2010-09-06T09:20:41Z-
dc.date.issued2009en_HK
dc.identifier.citationMount Sinai Journal Of Medicine, 2009, v. 76 n. 4, p. 392-403en_HK
dc.identifier.issn0027-2507en_HK
dc.identifier.urihttp://hdl.handle.net/10722/86735-
dc.description.abstractBackground: Smoking and alcohol are major causal factors for upper aerodigestive tract cancer, but reliable quantification of the combined impact of smoking and alcohol on this cancer and its major subtypes has not been performed. Methods: A meta-analysis of studies that had published quantitative estimates of smoking and upper aerodigestive tract cancer by January 2007 was performed. Pooled estimates of relative risks were obtained. Publication bias was investigated through funnel plots and corrected if found to be present. Results: Overall, 85 studies with information on 53,940 individuals with upper aerodigestive tract cancer were included. The pooled estimate for the association between smoking and the risk of this cancer was 3.47 (95% confidence interval, 3.06-3.92). The risk remained elevated for a decade after smoking cessation but declined thereafter. Individuals who both smoked and consumed alcohol had double the risk of upper aerodigestive tract cancer in comparison with those who only smoked: the relative risk was 6.93 (95% confidence interval, 4.99-9.62) for the former and 2.56 (95% confidence interval, 2.20-2.97) for the latter (P < 0.001). Conclusions: Public health interventions that simultaneously discourage smoking and heavy drinking would have greater benefits than would be expected from those that target only one of these risk factors. © 2009 Mount Sinai School of Medicine.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc.en_HK
dc.relation.ispartofMount Sinai Journal of Medicineen_HK
dc.rightsMount Sinai Journal of Medicine. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshAlcohol Drinking - adverse effectsen_HK
dc.subject.meshEsophageal Neoplasms - epidemiology - etiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLaryngeal Neoplasms - epidemiology - etiologyen_HK
dc.subject.meshOropharyngeal Neoplasms - epidemiology - etiologyen_HK
dc.subject.meshPublication Biasen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshSmoking - adverse effectsen_HK
dc.subject.meshSmoking Cessationen_HK
dc.titleRisk of upper aerodigestive tract cancer associated with smoking with and without concurrent alcohol consumptionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0027-2507&volume=76&issue=4&spage=392&epage=403&date=2009&atitle=Risk+of+upper+aerodigestive+tract+cancer+associated+with+smoking+with+and+without+concurrent+alcohol+consumptionen_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/msj.20125en_HK
dc.identifier.pmid19642154-
dc.identifier.scopuseid_2-s2.0-70049093127en_HK
dc.identifier.hkuros161634en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70049093127&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume76en_HK
dc.identifier.issue4en_HK
dc.identifier.spage392en_HK
dc.identifier.epage403en_HK
dc.identifier.isiWOS:000268553700010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridAnsaryMoghaddam, A=8608489600en_HK
dc.identifier.scopusauthoridHuxley, RR=6701828350en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridWoodward, M=7102510958en_HK

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