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Article: A novel behavioral method to detect motoneuron disease in Wobbler mice aged three to seven days old

TitleA novel behavioral method to detect motoneuron disease in Wobbler mice aged three to seven days old
Authors
Issue Date1998
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 1998, v. 813 n. 2, p. 334-342 How to Cite?
AbstractThe Wobbler mouse possesses an inherited autosomal recessive form of motoneuron disease. The most characteristic abnormality is the degeneration of motoneurons, mostly in the cervical spinal cord, and in the brain stem cranial motor nuclei. The underlying pathology shows up as symptoms that are only detectable confidently around the time of weaning (age 3 weeks). We now report a new method designed to identify presymptomatic Wobbler mice by behavioral and statistical approaches. We measured body weight, righting reflex (RR) and gender to examine whether these parameters have an impact on the status of the disease before age 3 weeks. Using a total of 341 NFR/wr strain pups, we found a strong association between RR and the Wobbler disease status (p < 0.0001) between postnatal days 3 to 7, and achieved greater than 97% correct classification of Wobblers. Therefore the measurement of RR allows the early detection of the affected Wobbler (wr/wr) mice with a minimum of error. This method has been used in our laboratory for immunocytochemical studies that show the early sprouting of immunoreactive serotonin and peptidergic fibers in the cervical spinal ventral horn by postnatal days 7 and 12 respectively. The early detection of Wobbler mice thus facilitates significant new understanding regarding [he pathogenesis of motoneuron disease. We can now examine potentially therapeutic approaches which may be more effective than when administered in the symptomatic weanlings (work in progress).
Persistent Identifierhttp://hdl.handle.net/10722/86689
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBose, Pen_HK
dc.contributor.authorFielding, Ren_HK
dc.contributor.authorAmeis, KMen_HK
dc.contributor.authorVaccaGalloway, LLen_HK
dc.date.accessioned2010-09-06T09:20:07Z-
dc.date.available2010-09-06T09:20:07Z-
dc.date.issued1998en_HK
dc.identifier.citationBrain Research, 1998, v. 813 n. 2, p. 334-342en_HK
dc.identifier.issn0006-8993en_HK
dc.identifier.urihttp://hdl.handle.net/10722/86689-
dc.description.abstractThe Wobbler mouse possesses an inherited autosomal recessive form of motoneuron disease. The most characteristic abnormality is the degeneration of motoneurons, mostly in the cervical spinal cord, and in the brain stem cranial motor nuclei. The underlying pathology shows up as symptoms that are only detectable confidently around the time of weaning (age 3 weeks). We now report a new method designed to identify presymptomatic Wobbler mice by behavioral and statistical approaches. We measured body weight, righting reflex (RR) and gender to examine whether these parameters have an impact on the status of the disease before age 3 weeks. Using a total of 341 NFR/wr strain pups, we found a strong association between RR and the Wobbler disease status (p < 0.0001) between postnatal days 3 to 7, and achieved greater than 97% correct classification of Wobblers. Therefore the measurement of RR allows the early detection of the affected Wobbler (wr/wr) mice with a minimum of error. This method has been used in our laboratory for immunocytochemical studies that show the early sprouting of immunoreactive serotonin and peptidergic fibers in the cervical spinal ventral horn by postnatal days 7 and 12 respectively. The early detection of Wobbler mice thus facilitates significant new understanding regarding [he pathogenesis of motoneuron disease. We can now examine potentially therapeutic approaches which may be more effective than when administered in the symptomatic weanlings (work in progress).en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_HK
dc.relation.ispartofBrain Researchen_HK
dc.rightsBrain Research. Copyright © Elsevier BV.en_HK
dc.subject.meshAge Factorsen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshBehavior, Animal - physiologyen_HK
dc.subject.meshBody Weighten_HK
dc.subject.meshLogistic Modelsen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Inbred C57BLen_HK
dc.subject.meshMice, Neurologic Mutantsen_HK
dc.subject.meshMotor Neuron Disease - diagnosis - genetics - physiopathologyen_HK
dc.subject.meshNerve Degeneration - diagnosis - genetics - physiopathologyen_HK
dc.subject.meshPhenotypeen_HK
dc.subject.meshReflex, Abnormal - geneticsen_HK
dc.subject.meshSex Factorsen_HK
dc.titleA novel behavioral method to detect motoneuron disease in Wobbler mice aged three to seven days olden_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0006-8993&volume=813&spage=334&epage=342&date=1998&atitle=A+novel+behavioral+method+to+detect+motoneuron+disease+in+Wobbler+mice+aged+three+to+seven+days+olden_HK
dc.identifier.emailFielding, R:fielding@hku.hken_HK
dc.identifier.authorityFielding, R=rp00339en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0006-8993(98)01033-6en_HK
dc.identifier.pmid9838183-
dc.identifier.scopuseid_2-s2.0-0009496692en_HK
dc.identifier.hkuros39176en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0009496692&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume813en_HK
dc.identifier.issue2en_HK
dc.identifier.spage334en_HK
dc.identifier.epage342en_HK
dc.identifier.isiWOS:000077234900012-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridBose, P=7103009659en_HK
dc.identifier.scopusauthoridFielding, R=7102200484en_HK
dc.identifier.scopusauthoridAmeis, KM=6503850340en_HK
dc.identifier.scopusauthoridVaccaGalloway, LL=6602468305en_HK

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