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Article: Moderate alcohol use and mortality from ischaemic heart disease: A prospective study in older Chinese people

TitleModerate alcohol use and mortality from ischaemic heart disease: A prospective study in older Chinese people
Authors
Issue Date2008
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
Plos One, 2008, v. 3 n. 6 How to Cite?
AbstractBackground: Moderate alcohol use is generally associated with lower ischaemic heart disease (IHD) mortality but it is difficult to ascertain whether this is due to attributes of moderate alcohol users or the properties of alcohol itself. Evidence from populations with different patterns of alcohol use and IHD can provide crucial evidence. We assessed the association of moderate alcohol use with IHD mortality in older Chinese people from Hong Kong. Methodology: We used Cox regression to determine whether moderate alcohol use was associated with IHD mortality in a prospective, population-based cohort study of all 56167 attendees, aged 65 years or over, from July 1998 to December 2000 at all 18 Elderly Health Centers operated by the Department of Health in Hong Kong. Principal Findings: After a median follow-up of 4.2 years, there were 406 (188 in men, 218 in women) deaths from IHD in 54,090 subjects (96.3% successful follow-up). Moderate alcohol use in men was not associated with IHD mortality adjusted only for age [Hazard Ratio, HR 1.01 (95% Cl 0.55 to 1.84) compared with never drinkers] or additionally adjusted for socio-economic status and lifestyle. Almost all women were occasional drinkers and their current alcohol use was not significantly associated with IHD mortality [HR 0.88, (95% Cl 0.51 to 1.53)] Conclusions: Moderate alcohol use had no effect on IHD mortality in older Chinese men. Lack of replication of the usual protective effect of moderate alcohol use in a setting with a different pattern of alcohol use and IHD could be due to chance or could suggest that the protective effect of alcohol on IHD does not extend to all populations. © 2008 Schooling et al.
Persistent Identifierhttp://hdl.handle.net/10722/86674
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Health Care & Promotion Fund Committee in Hong KongHSRC#S111016
Funding Information:

This project was funded by the Health Care & Promotion Fund Committee in Hong Kong (Grant: HSRC#S111016). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

References

 

DC FieldValueLanguage
dc.contributor.authorSchooling, CMen_HK
dc.contributor.authorWenjie, Sen_HK
dc.contributor.authorHo, SYen_HK
dc.contributor.authorChan, WMen_HK
dc.contributor.authorTham, MKen_HK
dc.contributor.authorHo, KSen_HK
dc.contributor.authorLeung, GMen_HK
dc.contributor.authorLam, THen_HK
dc.date.accessioned2010-09-06T09:19:56Z-
dc.date.available2010-09-06T09:19:56Z-
dc.date.issued2008en_HK
dc.identifier.citationPlos One, 2008, v. 3 n. 6en_HK
dc.identifier.issn1932-6203en_HK
dc.identifier.urihttp://hdl.handle.net/10722/86674-
dc.description.abstractBackground: Moderate alcohol use is generally associated with lower ischaemic heart disease (IHD) mortality but it is difficult to ascertain whether this is due to attributes of moderate alcohol users or the properties of alcohol itself. Evidence from populations with different patterns of alcohol use and IHD can provide crucial evidence. We assessed the association of moderate alcohol use with IHD mortality in older Chinese people from Hong Kong. Methodology: We used Cox regression to determine whether moderate alcohol use was associated with IHD mortality in a prospective, population-based cohort study of all 56167 attendees, aged 65 years or over, from July 1998 to December 2000 at all 18 Elderly Health Centers operated by the Department of Health in Hong Kong. Principal Findings: After a median follow-up of 4.2 years, there were 406 (188 in men, 218 in women) deaths from IHD in 54,090 subjects (96.3% successful follow-up). Moderate alcohol use in men was not associated with IHD mortality adjusted only for age [Hazard Ratio, HR 1.01 (95% Cl 0.55 to 1.84) compared with never drinkers] or additionally adjusted for socio-economic status and lifestyle. Almost all women were occasional drinkers and their current alcohol use was not significantly associated with IHD mortality [HR 0.88, (95% Cl 0.51 to 1.53)] Conclusions: Moderate alcohol use had no effect on IHD mortality in older Chinese men. Lack of replication of the usual protective effect of moderate alcohol use in a setting with a different pattern of alcohol use and IHD could be due to chance or could suggest that the protective effect of alcohol on IHD does not extend to all populations. © 2008 Schooling et al.en_HK
dc.languageengen_HK
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_HK
dc.relation.ispartofPLoS ONEen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAlcohol Drinking-
dc.subject.meshChina-
dc.subject.meshCohort Studies-
dc.subject.meshMyocardial Ischemia - physiopathology-
dc.subject.meshProportional Hazards Models-
dc.titleModerate alcohol use and mortality from ischaemic heart disease: A prospective study in older Chinese peopleen_HK
dc.typeArticleen_HK
dc.identifier.emailSchooling, CM:cms1@hkucc.hku.hken_HK
dc.identifier.emailHo, SY:syho@hku.hken_HK
dc.identifier.emailLeung, GM:gmleung@hku.hken_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authoritySchooling, CM=rp00504en_HK
dc.identifier.authorityHo, SY=rp00427en_HK
dc.identifier.authorityLeung, GM=rp00460en_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0002370en_HK
dc.identifier.pmid18523644en_HK
dc.identifier.pmcidPMC2396290-
dc.identifier.scopuseid_2-s2.0-48649100146en_HK
dc.identifier.hkuros142851en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-48649100146&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume3en_HK
dc.identifier.issue6en_HK
dc.identifier.spagee2370-
dc.identifier.epagee2370-
dc.identifier.isiWOS:000262614300056-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSchooling, CM=12808565000en_HK
dc.identifier.scopusauthoridWenjie, S=24491084300en_HK
dc.identifier.scopusauthoridHo, SY=7403716884en_HK
dc.identifier.scopusauthoridChan, WM=7403914485en_HK
dc.identifier.scopusauthoridTham, MK=24491128900en_HK
dc.identifier.scopusauthoridHo, KS=36819421100en_HK
dc.identifier.scopusauthoridLeung, GM=7007159841en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK

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