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Article: Impact of impaired fasting glucose and impaired glucose tolerance on arterial stiffness in an older Chinese population: the Guangzhou Biobank Cohort Study-CVD

TitleImpact of impaired fasting glucose and impaired glucose tolerance on arterial stiffness in an older Chinese population: the Guangzhou Biobank Cohort Study-CVD
Authors
Issue Date2010
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/metabol
Citation
Metabolism: Clinical And Experimental, 2010, v. 59 n. 3, p. 367-372 How to Cite?
AbstractThe aim of the study was to compare the impact of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) on vascular function among older Chinese people. A random sample of 671 men and 603 women aged 50 to 85 years without known diabetes from the Guangzhou Biobank Study-CVD was examined in a cross-sectional study. Subjects with no previously confirmed or treated diabetes but with both fasting plasma glucose less than 5.6 mmol/L and 2-hour glucose from 7.8 to less than 11.0 mmol/L were classified as having isolated IGT, and those with no previously confirmed and treated diabetes but with both fasting plasma glucose from 5.6 to less than 7.0 mmol/L and 2-hour glucose less than 7.8 mmol/L were classified as having isolated IFG. A total of 11.0% of the men and 8.6% of the women had isolated IFG, and 17.7% of the men and 18.6% of the women had isolated IGT. The brachial-ankle pulse wave velocity and pulse pressure were increased in both the isolated IFG and isolated IGT subjects compared with the normoglycemia group (both Ps < .001). Compared with subjects with isolated IFG, those with isolated IGT appeared to have a higher age- and sex-adjusted brachial-ankle pulse wave velocity (1543 ± 22 vs 1566 ± 17, P = .07) and to be more insulin resistant (2-hour postload insulin: 54.2 ± 2.13 vs 26.8 ± 2.99 μU/mL, P < .001), had a worse lipid profile (apolipoprotein [apo] B: 1.07 ± 0.02 vs 0.97 ± 0.02g/L, P < .001; apo B/apo A-1 ratio: 0.80 ± 0.02 vs 0.69 ± 0.02, P < .001), but had lower glycosylated hemoglobin levels (6.03% ± 0.06% vs 5.86% ± 0.04%, P < .001) (values are mean ± SE). Subjects with isolated IGT had greater arterial stiffness, probably as a result of being more insulin resistant, with a worse lipid profile than those with isolated IFG. The sole use of fasting glucose level to identify prediabetic people would fail to identify a significant proportion of the at-risk population. © 2010 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/86648
ISSN
2015 Impact Factor: 4.375
2015 SCImago Journal Rankings: 1.978
ISI Accession Number ID
Funding AgencyGrant Number
National Natural Science Foundation of China/Research Grants Council30518001
HKU720/05
University of Hong Kong Foundation for Educational Development and Research, Hong Kong
Guangzhou Public Health Bureau
Guangzhou Science and Technology Bureau, Guangzhou, China
University of Birmingham, United Kingdom
Funding Information:

The study is funded by the National Natural Science Foundation of China/Research Grants Council (30518001; HKU720/05) grant. The University of Hong Kong Foundation for Educational Development and Research, Hong Kong; the Guangzhou Public Health Bureau and the Guangzhou Science and Technology Bureau, Guangzhou, China; and The University of Birmingham, United Kingdom. The GBCS-CVD investigators include the Guangzhou No. 12 Hospital: JM Lin, XJ Yue, CQ Jiang (coprincipal investigator); The University of Hong Kong: TH Lam; The Chinese University of Hong Kong: B Tomlinson, KS Wong; The University of Birmingham: B Cheung, GN Thomas (coprincipal investigator).

References

 

DC FieldValueLanguage
dc.contributor.authorXu, Len_HK
dc.contributor.authorJiang, CQen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorCheng, KKen_HK
dc.contributor.authorYue, XJen_HK
dc.contributor.authorLin, JMen_HK
dc.contributor.authorZhang, WSen_HK
dc.contributor.authorThomas, GNen_HK
dc.date.accessioned2010-09-06T09:19:37Z-
dc.date.available2010-09-06T09:19:37Z-
dc.date.issued2010en_HK
dc.identifier.citationMetabolism: Clinical And Experimental, 2010, v. 59 n. 3, p. 367-372en_HK
dc.identifier.issn0026-0495en_HK
dc.identifier.urihttp://hdl.handle.net/10722/86648-
dc.description.abstractThe aim of the study was to compare the impact of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) on vascular function among older Chinese people. A random sample of 671 men and 603 women aged 50 to 85 years without known diabetes from the Guangzhou Biobank Study-CVD was examined in a cross-sectional study. Subjects with no previously confirmed or treated diabetes but with both fasting plasma glucose less than 5.6 mmol/L and 2-hour glucose from 7.8 to less than 11.0 mmol/L were classified as having isolated IGT, and those with no previously confirmed and treated diabetes but with both fasting plasma glucose from 5.6 to less than 7.0 mmol/L and 2-hour glucose less than 7.8 mmol/L were classified as having isolated IFG. A total of 11.0% of the men and 8.6% of the women had isolated IFG, and 17.7% of the men and 18.6% of the women had isolated IGT. The brachial-ankle pulse wave velocity and pulse pressure were increased in both the isolated IFG and isolated IGT subjects compared with the normoglycemia group (both Ps < .001). Compared with subjects with isolated IFG, those with isolated IGT appeared to have a higher age- and sex-adjusted brachial-ankle pulse wave velocity (1543 ± 22 vs 1566 ± 17, P = .07) and to be more insulin resistant (2-hour postload insulin: 54.2 ± 2.13 vs 26.8 ± 2.99 μU/mL, P < .001), had a worse lipid profile (apolipoprotein [apo] B: 1.07 ± 0.02 vs 0.97 ± 0.02g/L, P < .001; apo B/apo A-1 ratio: 0.80 ± 0.02 vs 0.69 ± 0.02, P < .001), but had lower glycosylated hemoglobin levels (6.03% ± 0.06% vs 5.86% ± 0.04%, P < .001) (values are mean ± SE). Subjects with isolated IGT had greater arterial stiffness, probably as a result of being more insulin resistant, with a worse lipid profile than those with isolated IFG. The sole use of fasting glucose level to identify prediabetic people would fail to identify a significant proportion of the at-risk population. © 2010 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/metabolen_HK
dc.relation.ispartofMetabolism: Clinical and Experimentalen_HK
dc.subject.meshAged - physiologyen_HK
dc.subject.meshAnkle Brachial Indexen_HK
dc.subject.meshArteries - physiopathologyen_HK
dc.subject.meshBlood Glucose - metabolismen_HK
dc.subject.meshCardiovascular Diseases - epidemiologyen_HK
dc.subject.meshChina - epidemiologyen_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshDiabetes Mellitus - blood - epidemiologyen_HK
dc.subject.meshFasting - metabolismen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGlucose Intolerance - epidemiology - physiopathologyen_HK
dc.subject.meshGlucose Tolerance Testen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHyperglycemia - blood - epidemiologyen_HK
dc.subject.meshLife Styleen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshQuestionnairesen_HK
dc.subject.meshRisk Factorsen_HK
dc.titleImpact of impaired fasting glucose and impaired glucose tolerance on arterial stiffness in an older Chinese population: the Guangzhou Biobank Cohort Study-CVDen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0026-0495&volume=59&issue=3&spage=367&epage=372&date=2010&atitle=Impact+of+impaired+fasting+glucose+and+impaired+glucose+tolerance+on+arterial+stiffness+in+an+older+Chinese+population:+The+Guangzhou+Biobank+Cohort+Study-CVDen_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.metabol.2009.08.004en_HK
dc.identifier.pmid19828159-
dc.identifier.scopuseid_2-s2.0-76249122883en_HK
dc.identifier.hkuros169079en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-76249122883&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume59en_HK
dc.identifier.issue3en_HK
dc.identifier.spage367en_HK
dc.identifier.epage372en_HK
dc.identifier.isiWOS:000276761800010-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridXu, L=7404744449en_HK
dc.identifier.scopusauthoridJiang, CQ=10639500500en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridCheng, KK=7402997800en_HK
dc.identifier.scopusauthoridYue, XJ=35410971600en_HK
dc.identifier.scopusauthoridLin, JM=35409737900en_HK
dc.identifier.scopusauthoridZhang, WS=13410704100en_HK
dc.identifier.scopusauthoridThomas, GN=35465269900en_HK

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