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Article: Identification of factors differentially associated with isolated impaired fasting glucose and isolated post-load impaired glucose tolerance: The Hong Kong Cardiovascular Risk Factor Study

TitleIdentification of factors differentially associated with isolated impaired fasting glucose and isolated post-load impaired glucose tolerance: The Hong Kong Cardiovascular Risk Factor Study
Authors
Issue Date2006
PublisherBioScientifica Ltd. The Journal's web site is located at http://www.eje-online.org/
Citation
European Journal Of Endocrinology, 2006, v. 155 n. 4, p. 623-632 How to Cite?
AbstractBackground: The use of fasting and post-prandial glucose levels in the classification of hyperglycaemic states often identifies distinct subjects, but the factors determining these intermediate-isolated glucose intolerant states are yet to be clearly elucidated in Chinese subjects. Methods: Representative subjects (n=2769) were randomly recruited from the Hong Kong Chinese population and glycaemic status was determined using both fasting and 2h 75 g oral glucose tolerance test glucose levels. The relationship between the groups with isolated glucose intolerance and vascular risk factors was investigated using ANOVA and logistic regression analyses. Results: Using either criterion, diabetes was identified in 265 (9.6%) subjects and glucose intolerance in 568 (20.5%) subjects. Of those 568, isolated impaired glucose tolerance (IGT) using the post-load criterion was identified in 49.5% and isolated impaired fasting glucose (IFG) in 30.5%. Ageing and hyperinsulinaemia were common determinants of IGT and IFG; with small hip circumference a marker of poorer early life development and being born in China rather than Hong Kong, a possible low birth weight marker was also associated with LFG. Hypertension, hypertriglyceridaemia and poor education were also associated with IGT. When we looked for factors differentially associated with these glucose intolerant states, female sex, greater hip circumference, high triglyceride levels, low fasting insulin levels, and not being born in China were independently associated with isolated IGT compared with isolated IFG. Conclusion: Despite common antecedents to the glucose intolerant states, isolated IFG appeared to be particularly associated with early life development, and isolated IGT was more strongly associated with obesity-related determinants such as hypertriglyceridaemia. © 2006 Society of the European Journal of Endocrinology.
Persistent Identifierhttp://hdl.handle.net/10722/86632
ISSN
2015 Impact Factor: 3.892
2015 SCImago Journal Rankings: 1.579
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorThomas, GNen_HK
dc.contributor.authorSchooling, CMen_HK
dc.contributor.authorMcGhee, SMen_HK
dc.contributor.authorHo, SYen_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorWat, NMen_HK
dc.contributor.authorJanus, EDen_HK
dc.contributor.authorLam, THen_HK
dc.date.accessioned2010-09-06T09:19:25Z-
dc.date.available2010-09-06T09:19:25Z-
dc.date.issued2006en_HK
dc.identifier.citationEuropean Journal Of Endocrinology, 2006, v. 155 n. 4, p. 623-632en_HK
dc.identifier.issn0804-4643en_HK
dc.identifier.urihttp://hdl.handle.net/10722/86632-
dc.description.abstractBackground: The use of fasting and post-prandial glucose levels in the classification of hyperglycaemic states often identifies distinct subjects, but the factors determining these intermediate-isolated glucose intolerant states are yet to be clearly elucidated in Chinese subjects. Methods: Representative subjects (n=2769) were randomly recruited from the Hong Kong Chinese population and glycaemic status was determined using both fasting and 2h 75 g oral glucose tolerance test glucose levels. The relationship between the groups with isolated glucose intolerance and vascular risk factors was investigated using ANOVA and logistic regression analyses. Results: Using either criterion, diabetes was identified in 265 (9.6%) subjects and glucose intolerance in 568 (20.5%) subjects. Of those 568, isolated impaired glucose tolerance (IGT) using the post-load criterion was identified in 49.5% and isolated impaired fasting glucose (IFG) in 30.5%. Ageing and hyperinsulinaemia were common determinants of IGT and IFG; with small hip circumference a marker of poorer early life development and being born in China rather than Hong Kong, a possible low birth weight marker was also associated with LFG. Hypertension, hypertriglyceridaemia and poor education were also associated with IGT. When we looked for factors differentially associated with these glucose intolerant states, female sex, greater hip circumference, high triglyceride levels, low fasting insulin levels, and not being born in China were independently associated with isolated IGT compared with isolated IFG. Conclusion: Despite common antecedents to the glucose intolerant states, isolated IFG appeared to be particularly associated with early life development, and isolated IGT was more strongly associated with obesity-related determinants such as hypertriglyceridaemia. © 2006 Society of the European Journal of Endocrinology.en_HK
dc.languageengen_HK
dc.publisherBioScientifica Ltd. The Journal's web site is located at http://www.eje-online.org/en_HK
dc.relation.ispartofEuropean Journal of Endocrinologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshBlood Glucose - analysisen_HK
dc.subject.meshCardiovascular Diseases - blood - epidemiologyen_HK
dc.subject.meshChina - epidemiologyen_HK
dc.subject.meshFasting - blooden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGlucose Intolerance - blood - etiologyen_HK
dc.subject.meshGlucose Tolerance Testen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshOdds Ratioen_HK
dc.subject.meshPrevalenceen_HK
dc.subject.meshRisk Factorsen_HK
dc.titleIdentification of factors differentially associated with isolated impaired fasting glucose and isolated post-load impaired glucose tolerance: The Hong Kong Cardiovascular Risk Factor Studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0804-4643&volume=155&spage=623&epage=32&date=2006&atitle=Identification+of+factors+differentially+associated+with+isolated+impaired+fasting+glucose+and+isolated+post-load+impaired+glucose+tolerance:+The+Hong+Kong+cardiovascular+risk+factor+studyen_HK
dc.identifier.emailSchooling, CM:cms1@hkucc.hku.hken_HK
dc.identifier.emailMcGhee, SM:smmcghee@hkucc.hku.hken_HK
dc.identifier.emailHo, SY:syho@hku.hken_HK
dc.identifier.emailCheung, BMY:mycheung@hku.hken_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authoritySchooling, CM=rp00504en_HK
dc.identifier.authorityMcGhee, SM=rp00393en_HK
dc.identifier.authorityHo, SY=rp00427en_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1530/eje.1.02250en_HK
dc.identifier.pmid16990663-
dc.identifier.scopuseid_2-s2.0-33750230974en_HK
dc.identifier.hkuros127247en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33750230974&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume155en_HK
dc.identifier.issue4en_HK
dc.identifier.spage623en_HK
dc.identifier.epage632en_HK
dc.identifier.isiWOS:000241498000015-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridThomas, GN=35465269900en_HK
dc.identifier.scopusauthoridSchooling, CM=12808565000en_HK
dc.identifier.scopusauthoridMcGhee, SM=7003288588en_HK
dc.identifier.scopusauthoridHo, SY=7403716884en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridWat, NM=6602131754en_HK
dc.identifier.scopusauthoridJanus, ED=7006936536en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK

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