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Article: A comparison of the associations between risk factors and cardiovascular disease in Asia and Australasia

TitleA comparison of the associations between risk factors and cardiovascular disease in Asia and Australasia
Authors
Issue Date2005
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.escardio.org/initiatives/journals/prevention
Citation
European Journal Of Cardiovascular Prevention And Rehabilitation, 2005, v. 12 n. 5, p. 484-491 How to Cite?
AbstractBACKGROUND: Cardiovascular disease is already the leading cause of death in many Asian populations. Relationships between vascular risk factors and cardiovascular disease may differ in Asian and western populations. Previously, a lack of prospective data has prevented the reliable quantification of such differences, which, if they were shown to exist, would suggest that novel cardiovascular prevention and treatment strategies are required for Asia. DESIGN: An individual participant data meta-analysis of 32 studies from the Asia-Pacific region involving 331 100 subjects (75% from Asia; 25% from the predominantly Caucasian populations of Australia and New Zealand). METHODS: Outcomes were death from coronary heart disease, ischaemic and haemorrhagic stroke. Hazard ratios were estimated from Cox models for systolic blood pressure (SBP), total cholesterol, triglycerides, body mass index, diabetes and current cigarette smoking, stratified by study and sex and adjusted for age, the other risk factors and regression dilution. RESULTS: After an average period of follow-up of 4 years there were 2082 deaths from coronary heart disease, 600 from haemorrhagic stroke and 420 from ischaemic stroke. The direction and strength of the associations between risk factors and cardiovascular outcomes were similar in the two regions, although in two cases there were significant differences. Triglycerides were more strongly associated with coronary heart disease in Australia and New Zealand (P=0.03), whereas SBP showed a stronger relationship with haemorrhagic stroke in Asia (P=0.04). CONCLUSIONS: Classical vascular risk factors act similarly in Asian and Caucasian populations; prevention and treatment strategies should thus be similar. Blood pressure reduction should be particularly effective in Asia. © 2005 European Society of Cardiology.
Persistent Identifierhttp://hdl.handle.net/10722/86627
ISSN
2013 Impact Factor: 3.691
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWoodward, Men_HK
dc.contributor.authorHuxley, Ren_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorBarzi, Fen_HK
dc.contributor.authorLawes, CMMen_HK
dc.contributor.authorUeshima, Hen_HK
dc.date.accessioned2010-09-06T09:19:21Z-
dc.date.available2010-09-06T09:19:21Z-
dc.date.issued2005en_HK
dc.identifier.citationEuropean Journal Of Cardiovascular Prevention And Rehabilitation, 2005, v. 12 n. 5, p. 484-491en_HK
dc.identifier.issn1741-8267en_HK
dc.identifier.urihttp://hdl.handle.net/10722/86627-
dc.description.abstractBACKGROUND: Cardiovascular disease is already the leading cause of death in many Asian populations. Relationships between vascular risk factors and cardiovascular disease may differ in Asian and western populations. Previously, a lack of prospective data has prevented the reliable quantification of such differences, which, if they were shown to exist, would suggest that novel cardiovascular prevention and treatment strategies are required for Asia. DESIGN: An individual participant data meta-analysis of 32 studies from the Asia-Pacific region involving 331 100 subjects (75% from Asia; 25% from the predominantly Caucasian populations of Australia and New Zealand). METHODS: Outcomes were death from coronary heart disease, ischaemic and haemorrhagic stroke. Hazard ratios were estimated from Cox models for systolic blood pressure (SBP), total cholesterol, triglycerides, body mass index, diabetes and current cigarette smoking, stratified by study and sex and adjusted for age, the other risk factors and regression dilution. RESULTS: After an average period of follow-up of 4 years there were 2082 deaths from coronary heart disease, 600 from haemorrhagic stroke and 420 from ischaemic stroke. The direction and strength of the associations between risk factors and cardiovascular outcomes were similar in the two regions, although in two cases there were significant differences. Triglycerides were more strongly associated with coronary heart disease in Australia and New Zealand (P=0.03), whereas SBP showed a stronger relationship with haemorrhagic stroke in Asia (P=0.04). CONCLUSIONS: Classical vascular risk factors act similarly in Asian and Caucasian populations; prevention and treatment strategies should thus be similar. Blood pressure reduction should be particularly effective in Asia. © 2005 European Society of Cardiology.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.escardio.org/initiatives/journals/preventionen_HK
dc.relation.ispartofEuropean Journal of Cardiovascular Prevention and Rehabilitationen_HK
dc.rightsEuropean Journal of Cardiovascular Prevention & Rehabilitation. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subject.meshAsia - epidemiologyen_HK
dc.subject.meshAustralasiaen_HK
dc.subject.meshBody Mass Indexen_HK
dc.subject.meshCardiovascular Diseases - mortalityen_HK
dc.subject.meshDiabetes Mellitus - epidemiologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypertension - epidemiologyen_HK
dc.subject.meshLipids - blooden_HK
dc.subject.meshMaleen_HK
dc.subject.meshProportional Hazards Modelsen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshSmoking - epidemiologyen_HK
dc.subject.meshStroke - mortalityen_HK
dc.titleA comparison of the associations between risk factors and cardiovascular disease in Asia and Australasiaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1741-8267&volume=12&spage=484&epage=491&date=2005&atitle=A+comparison+of+the+associations+between+risk+factors+and+cardiovascular+disease+in+Asia+and+Australasiaen_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1097/01.hjr.0000170264.84820.8een_HK
dc.identifier.pmid16210936-
dc.identifier.scopuseid_2-s2.0-33644875581en_HK
dc.identifier.hkuros112397en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33644875581&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume12en_HK
dc.identifier.issue5en_HK
dc.identifier.spage484en_HK
dc.identifier.epage491en_HK
dc.identifier.isiWOS:000249264700011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWoodward, M=7102510958en_HK
dc.identifier.scopusauthoridHuxley, R=6701828350en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridBarzi, F=7003545543en_HK
dc.identifier.scopusauthoridLawes, CMM=6602516713en_HK
dc.identifier.scopusauthoridUeshima, H=7005129002en_HK

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