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Article: Blood lipid levels in relation to glucose status in seven populations of Asian origin without a prior history of diabetes: The DECODA study

TitleBlood lipid levels in relation to glucose status in seven populations of Asian origin without a prior history of diabetes: The DECODA study
Authors
Issue Date2009
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/10009394
Citation
Diabetes/Metabolism Research And Reviews, 2009, v. 25 n. 6, p. 549-557 How to Cite?
AbstractBackground: Dyslipidaemia commonly coexists with diabetes. We investigated the association of lipid profiles with glucose levels in populations of Asian origin without a prior history of diabetes. Methods: Cross-sectional data of 10 374 men and 12 552 women aged 30-74 years from 14 cohorts, representing seven populations of Asian origin were jointly analysed. Multivariable adjusted linear regression analyses with standardized regression coefficients (β) were performed to estimate relationships between lipids and plasma glucose. Results: Within each glucose category, fasting plasma glucose (FPG) levels were correlated with increasing levels of triglycerides (TGs), total cholesterol (TC), TC to high-density lipoprotein (HDL) ratio and non-HDL cholesterol (non-HDL-C) (p < 0.05 in most of the ethnic groups) and inversely associated with HDL-C (p < 0.05 in some, but not all, of the populations). The association of lipids with 2-h plasma glucose (2hPG) followed a similar pattern as that for the FPG, except that an inverse relationship between HDL-C and glucose was more commonly observed for 2hPG than for FPG among different ethnic groups. Conclusions: Hyperglycaemia is associated with adverse lipid profiles in Asians without a prior history of diabetes. The 2hPG appears to be more closely associated with lipid profiles than does FPG. When assessing the risk of cardiovascular disease, the association of the dyslipidaemia with intermediate hyperglycaemia needs to be considered. Copyright © 2009 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/86594
ISSN
2012 Impact Factor: 2.968
2015 SCImago Journal Rankings: 1.617
ISI Accession Number ID
Funding AgencyGrant Number
Academy of Finland118492
AstraZeneca R&D Molndal, Sweden
Funding Information:

This analysis has been carried out by unrestricted grants from Academy of Finland (118492) and AstraZeneca R&D Molndal, Sweden.

References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Len_HK
dc.contributor.authorQiao, Qen_HK
dc.contributor.authorTuomilehto, Jen_HK
dc.contributor.authorHammar, Nen_HK
dc.contributor.authorJanus, EDen_HK
dc.contributor.authorSöderberg, Sen_HK
dc.contributor.authorMohan, Ven_HK
dc.contributor.authorRamachandran, Aen_HK
dc.contributor.authorDong, YHen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorPang, ZCen_HK
dc.date.accessioned2010-09-06T09:18:57Z-
dc.date.available2010-09-06T09:18:57Z-
dc.date.issued2009en_HK
dc.identifier.citationDiabetes/Metabolism Research And Reviews, 2009, v. 25 n. 6, p. 549-557en_HK
dc.identifier.issn1520-7552en_HK
dc.identifier.urihttp://hdl.handle.net/10722/86594-
dc.description.abstractBackground: Dyslipidaemia commonly coexists with diabetes. We investigated the association of lipid profiles with glucose levels in populations of Asian origin without a prior history of diabetes. Methods: Cross-sectional data of 10 374 men and 12 552 women aged 30-74 years from 14 cohorts, representing seven populations of Asian origin were jointly analysed. Multivariable adjusted linear regression analyses with standardized regression coefficients (β) were performed to estimate relationships between lipids and plasma glucose. Results: Within each glucose category, fasting plasma glucose (FPG) levels were correlated with increasing levels of triglycerides (TGs), total cholesterol (TC), TC to high-density lipoprotein (HDL) ratio and non-HDL cholesterol (non-HDL-C) (p < 0.05 in most of the ethnic groups) and inversely associated with HDL-C (p < 0.05 in some, but not all, of the populations). The association of lipids with 2-h plasma glucose (2hPG) followed a similar pattern as that for the FPG, except that an inverse relationship between HDL-C and glucose was more commonly observed for 2hPG than for FPG among different ethnic groups. Conclusions: Hyperglycaemia is associated with adverse lipid profiles in Asians without a prior history of diabetes. The 2hPG appears to be more closely associated with lipid profiles than does FPG. When assessing the risk of cardiovascular disease, the association of the dyslipidaemia with intermediate hyperglycaemia needs to be considered. Copyright © 2009 John Wiley & Sons, Ltd.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/10009394en_HK
dc.relation.ispartofDiabetes/Metabolism Research and Reviewsen_HK
dc.rightsDiabetes - Metabolism: Research and Reviews. Copyright © John Wiley & Sons Ltd.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAgingen_HK
dc.subject.meshAsia - epidemiologyen_HK
dc.subject.meshAsian Continental Ancestry Groupen_HK
dc.subject.meshBlood Glucose - analysisen_HK
dc.subject.meshCardiovascular Diseases - prevention & controlen_HK
dc.subject.meshChi-Square Distributionen_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshCross-Sectional Studiesen_HK
dc.subject.meshData Collectionen_HK
dc.subject.meshDyslipidemias - complications - epidemiologyen_HK
dc.subject.meshFasting - blooden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGlucose Intolerance - complications - epidemiologyen_HK
dc.subject.meshGlucose Tolerance Testen_HK
dc.subject.meshHomeostasisen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHyperglycemia - complications - epidemiologyen_HK
dc.subject.meshHypoglycemia - complications - epidemiologyen_HK
dc.subject.meshLipids - blooden_HK
dc.subject.meshMaleen_HK
dc.subject.meshMass Screeningen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPopulation Surveillanceen_HK
dc.subject.meshPrevalenceen_HK
dc.subject.meshRegression Analysisen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshSex Characteristicsen_HK
dc.titleBlood lipid levels in relation to glucose status in seven populations of Asian origin without a prior history of diabetes: The DECODA studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1520-7552&volume=25&issue=6&spage=549&epage=557&date=2009&atitle=Blood+lipid+levels+in+relation+to+glucose+status+in+seven+populations+of+Asian+origin+without+a+prior+history+of+diabetes:+the+DECODA+studyen_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/dmrr.994en_HK
dc.identifier.pmid19585489-
dc.identifier.scopuseid_2-s2.0-70350613080en_HK
dc.identifier.hkuros164025en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70350613080&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue6en_HK
dc.identifier.spage549en_HK
dc.identifier.epage557en_HK
dc.identifier.isiWOS:000208253500008-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridZhang, L=40262867800en_HK
dc.identifier.scopusauthoridQiao, Q=7005824706en_HK
dc.identifier.scopusauthoridTuomilehto, J=16140703200en_HK
dc.identifier.scopusauthoridHammar, N=7006083229en_HK
dc.identifier.scopusauthoridJanus, ED=7006936536en_HK
dc.identifier.scopusauthoridSöderberg, S=35463005200en_HK
dc.identifier.scopusauthoridMohan, V=35509595400en_HK
dc.identifier.scopusauthoridRamachandran, A=7102252827en_HK
dc.identifier.scopusauthoridDong, YH=14033817800en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridPang, ZC=12806211900en_HK
dc.identifier.citeulike5297870-

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