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Article: Seasonal effects of influenza on mortality in a subtropical city

TitleSeasonal effects of influenza on mortality in a subtropical city
Authors
Issue Date2009
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/
Citation
Bmc Infectious Diseases, 2009, v. 9, p. 133 How to Cite?
AbstractBackground: Influenza has been associated with a heavy burden of mortality. In tropical or subtropical regions where influenza viruses circulate in the community most of the year, it is possible that there are seasonal variations in the effects of influenza on mortality, because of periodic changes in environment and host factors as well as the frequent emergence of new antigenically drifted virus strains. In this paper we explored this seasonal effect of influenza. Methods: A time-varying coefficient Poisson regression model was fitted to the weekly numbers of mortality of Hong Kong from 1996 to 2002. Excess risks associated with influenza were calculated to assess the seasonal effects of influenza. Results: We demonstrated that the effects of influenza were higher in winter and late spring/early summer than other seasons. The two-peak pattern of seasonal effects of influenza was found for cardio-respiratory disease and sub-categories pneumonia and influenza, chronic obstructive pulmonary disease, cerebrovascular diseases and ischemic heart disease as well as for all-cause deaths. Conclusion: The results provide insight into the possibility that seasonal factors may have impact on virulence of influenza besides their effects on virus transmission. The results warrant further studies into the mechanisms behind the seasonal effect of influenza. © 2009 Yang et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/86572
ISSN
2015 Impact Factor: 2.69
2015 SCImago Journal Rankings: 1.510
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Area of Excellence Scheme of the University Grants Committee of the Hong Kong Special Administrative RegionAoE/M-12/06
Control of Infectious Diseases/Health and Health Services Research Fund04050212
Funding Information:

This work was supported by the Area of Excellence Scheme of the University Grants Committee of the Hong Kong Special Administrative Region [AoE/M-12/06]; and the Research Fund for the Control of Infectious Diseases/Health and Health Services Research Fund [04050212]. The authors thank Dr Wilina Lim, the Government Virus Unit of the Department of Health of Hong Kong for providing the virology data.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorYang, Len_HK
dc.contributor.authorWong, CMen_HK
dc.contributor.authorChan, KPen_HK
dc.contributor.authorChau, PYKen_HK
dc.contributor.authorOu, CQen_HK
dc.contributor.authorChan, KHen_HK
dc.contributor.authorPeiris, JMen_HK
dc.date.accessioned2010-09-06T09:18:41Z-
dc.date.available2010-09-06T09:18:41Z-
dc.date.issued2009en_HK
dc.identifier.citationBmc Infectious Diseases, 2009, v. 9, p. 133en_HK
dc.identifier.issn1471-2334en_HK
dc.identifier.urihttp://hdl.handle.net/10722/86572-
dc.description.abstractBackground: Influenza has been associated with a heavy burden of mortality. In tropical or subtropical regions where influenza viruses circulate in the community most of the year, it is possible that there are seasonal variations in the effects of influenza on mortality, because of periodic changes in environment and host factors as well as the frequent emergence of new antigenically drifted virus strains. In this paper we explored this seasonal effect of influenza. Methods: A time-varying coefficient Poisson regression model was fitted to the weekly numbers of mortality of Hong Kong from 1996 to 2002. Excess risks associated with influenza were calculated to assess the seasonal effects of influenza. Results: We demonstrated that the effects of influenza were higher in winter and late spring/early summer than other seasons. The two-peak pattern of seasonal effects of influenza was found for cardio-respiratory disease and sub-categories pneumonia and influenza, chronic obstructive pulmonary disease, cerebrovascular diseases and ischemic heart disease as well as for all-cause deaths. Conclusion: The results provide insight into the possibility that seasonal factors may have impact on virulence of influenza besides their effects on virus transmission. The results warrant further studies into the mechanisms behind the seasonal effect of influenza. © 2009 Yang et al; licensee BioMed Central Ltd.en_HK
dc.languageengen_HK
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.biomedcentral.com/bmcinfectdis/en_HK
dc.relation.ispartofBMC Infectious Diseasesen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong Licenseen_HK
dc.subject.meshInfluenza, Human - mortality-
dc.subject.meshPoisson Distribution-
dc.subject.meshRegression Analysis-
dc.subject.meshRisk Factors-
dc.subject.meshSeasons-
dc.titleSeasonal effects of influenza on mortality in a subtropical cityen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1471-2334&volume=9&spage=133&epage=&date=2009&atitle=Seasonal+effects+of+influenza+on+mortality+in+a+subtropical+cityen_HK
dc.identifier.emailWong, CM: hrmrwcm@hku.hken_HK
dc.identifier.emailPeiris, JM: malik@hkucc.hku.hken_HK
dc.identifier.authorityWong, CM=rp00338en_HK
dc.identifier.authorityPeiris, JM=rp00410en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1471-2334-9-133en_HK
dc.identifier.pmid19698116-
dc.identifier.pmcidPMC2739210-
dc.identifier.scopuseid_2-s2.0-70349776716en_HK
dc.identifier.hkuros165488en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70349776716&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume9en_HK
dc.identifier.spage133en_HK
dc.identifier.epage133en_HK
dc.identifier.isiWOS:000270412200002-
dc.publisher.placeUnited Kingdomen_HK
dc.relation.projectEstimation of the effect of influenza on cardiorespiratory and all causes mortality in tropical and sub-tropical climates - a comparative study between Hong Kong, Singapore and Guangzhou for influence of seasonality and meteorological conditions-
dc.relation.projectControl of Pandemic and Inter-pandemic Influenza-
dc.identifier.scopusauthoridYang, L=7406279703en_HK
dc.identifier.scopusauthoridWong, CM=7404954904en_HK
dc.identifier.scopusauthoridChan, KP=54921825100en_HK
dc.identifier.scopusauthoridChau, PYK=34876162600en_HK
dc.identifier.scopusauthoridOu, CQ=36880461400en_HK
dc.identifier.scopusauthoridChan, KH=7406034307en_HK
dc.identifier.scopusauthoridPeiris, JM=7005486823en_HK
dc.identifier.citeulike5625858-

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