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- Publisher Website: 10.1002/dmrr.1059
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- PMID: 20054879
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Article: Brachial-ankle pulse wave velocity and cardiovascular risk factors in the non-diabetic and newly diagnosed diabetic Chinese: Guangzhou Biobank Cohort Study-CVD
Title | Brachial-ankle pulse wave velocity and cardiovascular risk factors in the non-diabetic and newly diagnosed diabetic Chinese: Guangzhou Biobank Cohort Study-CVD | ||||
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Authors | |||||
Keywords | Arterial stiffness Glycosylated haemoglobin A1c Normoglycaemia Pulse wave velocity | ||||
Issue Date | 2010 | ||||
Publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/10009394 | ||||
Citation | Diabetes/Metabolism Research And Reviews, 2010, v. 26 n. 2, p. 133-139 How to Cite? | ||||
Abstract | Background: Increased arterial stiffness is an important cause of cardiovascular disease (CVD). We examined determinants of arterial stiffness in subjects across strata of glycaemic status. Methods: A total of 1249 subjects from a sub-study of the Guangzhou Biobank Cohort Study (GBCS-CVD) had brachial-ankle pulse wave velocity (baPWV) measured by automatic oscillometric method. Major cardiovascular risk factors including glycosylated haemoglobin A1c (HbA 1c), high sensitivity C-reactive protein (hsCRP), fasting triglyceride, low- and high-density lipoprotein cholesterol and both fasting and post 2-h oral glucose-load glucose, systolic and diastolic blood pressure were assessed. Results In all, 649, 479 and 121 subjects were classified into normoglycaemia, impaired glucose metabolism (IGM) and newly diagnosed diabetes groups, respectively. Both age and systolic blood pressure were significantly associated with increased baPWV in all three groups (all p < 0.001). In both normoglycaemic and IGM groups, hsCRP and HbA 1c were positively associated with baPWV (p from 0.04 to <0.001), whereas current smoking and triglyceride were associated with baPWV in the normoglycaemic and IGM group, respectively (p = 0.04 and 0.001). No gender difference in baPWV was observed in the normoglycaemic or IGM groups. However, in the newly diagnosed diabetes group, men had higher baPWV than women (p = 0.01). Conclusions: In the normoglycaemic and IGM subjects, after adjusting for age, blood pressure and other confounders, increasing HbA 1c was associated with increased baPWV, suggesting a pathophysiological role of chronic glycaemia that can contribute to vascular disease risk in persons without diabetes. Copyright © 2010 John Wiley & Sons, Ltd. | ||||
Persistent Identifier | http://hdl.handle.net/10722/86563 | ||||
ISSN | 2023 Impact Factor: 4.6 2023 SCImago Journal Rankings: 1.991 | ||||
ISI Accession Number ID |
Funding Information: The study is funded by the National Natural Science Foundation of China/Research Grants Council (No. 30518001; HKU720/05) grant. The University of Hong Kong Foundation for Educational Development and Research, Hong Kong; the Guangzhou Public Health Bureau and the Guangzhou Science and Technology Bureau, Guangzhou, China; and The University of Birmingham, UK. The Guangzhou Biobank Cohort Study-CVD investigators include: the Guangzhou No. 12 Hospital: J. M. Lin, X. J. Yue, C. Q. Jiang (Co-PI); The University of Hong Kong: T. H. Lam; The Chinese University of Hong Kong: B. Tomlinson, K. S. Wong; The University of Birmingham: B. Cheung, G. N. Thomas (Co-PI). | ||||
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Xu, L | en_HK |
dc.contributor.author | Jiang, CQ | en_HK |
dc.contributor.author | Lam, TH | en_HK |
dc.contributor.author | Yue, XJ | en_HK |
dc.contributor.author | Cheng, KK | en_HK |
dc.contributor.author | Liu, B | en_HK |
dc.contributor.author | Jin, YL | en_HK |
dc.contributor.author | Zhang, WS | en_HK |
dc.contributor.author | Thomas, GN | en_HK |
dc.date.accessioned | 2010-09-06T09:18:34Z | - |
dc.date.available | 2010-09-06T09:18:34Z | - |
dc.date.issued | 2010 | en_HK |
dc.identifier.citation | Diabetes/Metabolism Research And Reviews, 2010, v. 26 n. 2, p. 133-139 | en_HK |
dc.identifier.issn | 1520-7552 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/86563 | - |
dc.description.abstract | Background: Increased arterial stiffness is an important cause of cardiovascular disease (CVD). We examined determinants of arterial stiffness in subjects across strata of glycaemic status. Methods: A total of 1249 subjects from a sub-study of the Guangzhou Biobank Cohort Study (GBCS-CVD) had brachial-ankle pulse wave velocity (baPWV) measured by automatic oscillometric method. Major cardiovascular risk factors including glycosylated haemoglobin A1c (HbA 1c), high sensitivity C-reactive protein (hsCRP), fasting triglyceride, low- and high-density lipoprotein cholesterol and both fasting and post 2-h oral glucose-load glucose, systolic and diastolic blood pressure were assessed. Results In all, 649, 479 and 121 subjects were classified into normoglycaemia, impaired glucose metabolism (IGM) and newly diagnosed diabetes groups, respectively. Both age and systolic blood pressure were significantly associated with increased baPWV in all three groups (all p < 0.001). In both normoglycaemic and IGM groups, hsCRP and HbA 1c were positively associated with baPWV (p from 0.04 to <0.001), whereas current smoking and triglyceride were associated with baPWV in the normoglycaemic and IGM group, respectively (p = 0.04 and 0.001). No gender difference in baPWV was observed in the normoglycaemic or IGM groups. However, in the newly diagnosed diabetes group, men had higher baPWV than women (p = 0.01). Conclusions: In the normoglycaemic and IGM subjects, after adjusting for age, blood pressure and other confounders, increasing HbA 1c was associated with increased baPWV, suggesting a pathophysiological role of chronic glycaemia that can contribute to vascular disease risk in persons without diabetes. Copyright © 2010 John Wiley & Sons, Ltd. | en_HK |
dc.language | eng | en_HK |
dc.publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/10009394 | en_HK |
dc.relation.ispartof | Diabetes/Metabolism Research and Reviews | en_HK |
dc.rights | Diabetes - Metabolism: Research and Reviews. Copyright © John Wiley & Sons Ltd. | en_HK |
dc.subject | Arterial stiffness | - |
dc.subject | Glycosylated haemoglobin A1c | - |
dc.subject | Normoglycaemia | - |
dc.subject | Pulse wave velocity | - |
dc.subject.mesh | Ankle - blood supply | en_HK |
dc.subject.mesh | Blood Flow Velocity - physiology | en_HK |
dc.subject.mesh | Cardiovascular Diseases - physiopathology | en_HK |
dc.subject.mesh | Diabetes Mellitus - physiopathology | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Hemoglobin A, Glycosylated - metabolism | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Male | en_HK |
dc.subject.mesh | Middle Aged | en_HK |
dc.subject.mesh | Pulsatile Flow | en_HK |
dc.subject.mesh | Pulse | en_HK |
dc.subject.mesh | Risk Factors | en_HK |
dc.title | Brachial-ankle pulse wave velocity and cardiovascular risk factors in the non-diabetic and newly diagnosed diabetic Chinese: Guangzhou Biobank Cohort Study-CVD | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1520-7552&volume=26&issue=2&spage=133&epage=139&date=2010&atitle=Brachial-ankle+pulse+wave+velocity+and+cardiovascular+risk+factors+in+the+non-diabetic+and+newly+diagnosed+diabetic+Chinese:+Guangzhou+Biobank+Cohort+Study-CVD | en_HK |
dc.identifier.email | Lam, TH:hrmrlth@hkucc.hku.hk | en_HK |
dc.identifier.authority | Lam, TH=rp00326 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/dmrr.1059 | en_HK |
dc.identifier.pmid | 20054879 | - |
dc.identifier.scopus | eid_2-s2.0-77950431330 | en_HK |
dc.identifier.hkuros | 169583 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-77950431330&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 26 | en_HK |
dc.identifier.issue | 2 | en_HK |
dc.identifier.spage | 133 | en_HK |
dc.identifier.epage | 139 | en_HK |
dc.identifier.isi | WOS:000276833600009 | - |
dc.publisher.place | United Kingdom | en_HK |
dc.identifier.scopusauthorid | Xu, L=7404744449 | en_HK |
dc.identifier.scopusauthorid | Jiang, CQ=10639500500 | en_HK |
dc.identifier.scopusauthorid | Lam, TH=7202522876 | en_HK |
dc.identifier.scopusauthorid | Yue, XJ=35410971600 | en_HK |
dc.identifier.scopusauthorid | Cheng, KK=7402997800 | en_HK |
dc.identifier.scopusauthorid | Liu, B=36079151900 | en_HK |
dc.identifier.scopusauthorid | Jin, YL=35558481400 | en_HK |
dc.identifier.scopusauthorid | Zhang, WS=13410704100 | en_HK |
dc.identifier.scopusauthorid | Thomas, GN=35465269900 | en_HK |
dc.identifier.issnl | 1520-7552 | - |