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Article: Association of vascular risk factors with increasing glycemia even in normoglycemic subjects in an older Chinese population: the Guangzhou Biobank Cohort Study

TitleAssociation of vascular risk factors with increasing glycemia even in normoglycemic subjects in an older Chinese population: the Guangzhou Biobank Cohort Study
Authors
Issue Date2006
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/metabol
Citation
Metabolism: Clinical And Experimental, 2006, v. 55 n. 8, p. 1035-1041 How to Cite?
AbstractHyperglycemia increases cardiovascular disease risk, but the association between increasing glycemia and cardiovascular risk factors, angina, and coronary heart disease in normoglycemic subjects is less clear, particularly in Chinese. We report on possible associations in a large group of Mainland Chinese subjects. A total of 10 400 older subjects (≥50 years) were recruited, and vascular risk factors were measured, including anthropometry, blood pressure, and fasting plasma biochemical factors including glucose, lipid profile, and C-reactive protein (CRP). Subjects were categorized by glycemic status, and the relationship between glycemia and cardiovascular risk factors was investigated using analysis of variance and multiple linear regression analyses. Tertiles of fasting glucose levels showed a clear positive relationship with cardiovascular risk factors including age, obesity, blood pressure, lipid levels, and CRP (P < .001 for all). The overall prevalence of self-reported vascular disease was low, but significantly associated with increasing glycemia. Multiple regression showed that waist circumference (standardized regression coefficient β = .10, P < .001), triglycerides (β = 0.16, P < .001), CRP (β = 0.06, P < .001), female sex (β = .03, P = .007), high-density lipoprotein cholesterol (β = -.02, P = .016), and mean arterial pressure (β = .06, P < .001) were independently associated with fasting glucose levels. Among the normoglycemic subjects (n = 5190), increasing glycemia was still associated with increasing obesity indices, systolic blood pressure, triglyceride, and CRP levels (all P < .05). Increasing glycemia, even in the reference range, is associated with increasing prevalence of vascular risk factors. Control of these risk factors, particularly obesity, the most important avoidable independent determinant of glycemia in normoglycemic subjects, is critical to reduce the risk of the associated vascular disease. © 2006 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/86538
ISSN
2015 Impact Factor: 4.375
2015 SCImago Journal Rankings: 1.978
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorThomas, GNen_HK
dc.contributor.authorJiang, CQen_HK
dc.contributor.authorMcGhee, SMen_HK
dc.contributor.authorZhang, WSen_HK
dc.contributor.authorLao, XQen_HK
dc.contributor.authorSchooling, Men_HK
dc.contributor.authorAdab, Pen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorCheng, KKen_HK
dc.date.accessioned2010-09-06T09:18:16Z-
dc.date.available2010-09-06T09:18:16Z-
dc.date.issued2006en_HK
dc.identifier.citationMetabolism: Clinical And Experimental, 2006, v. 55 n. 8, p. 1035-1041en_HK
dc.identifier.issn0026-0495en_HK
dc.identifier.urihttp://hdl.handle.net/10722/86538-
dc.description.abstractHyperglycemia increases cardiovascular disease risk, but the association between increasing glycemia and cardiovascular risk factors, angina, and coronary heart disease in normoglycemic subjects is less clear, particularly in Chinese. We report on possible associations in a large group of Mainland Chinese subjects. A total of 10 400 older subjects (≥50 years) were recruited, and vascular risk factors were measured, including anthropometry, blood pressure, and fasting plasma biochemical factors including glucose, lipid profile, and C-reactive protein (CRP). Subjects were categorized by glycemic status, and the relationship between glycemia and cardiovascular risk factors was investigated using analysis of variance and multiple linear regression analyses. Tertiles of fasting glucose levels showed a clear positive relationship with cardiovascular risk factors including age, obesity, blood pressure, lipid levels, and CRP (P < .001 for all). The overall prevalence of self-reported vascular disease was low, but significantly associated with increasing glycemia. Multiple regression showed that waist circumference (standardized regression coefficient β = .10, P < .001), triglycerides (β = 0.16, P < .001), CRP (β = 0.06, P < .001), female sex (β = .03, P = .007), high-density lipoprotein cholesterol (β = -.02, P = .016), and mean arterial pressure (β = .06, P < .001) were independently associated with fasting glucose levels. Among the normoglycemic subjects (n = 5190), increasing glycemia was still associated with increasing obesity indices, systolic blood pressure, triglyceride, and CRP levels (all P < .05). Increasing glycemia, even in the reference range, is associated with increasing prevalence of vascular risk factors. Control of these risk factors, particularly obesity, the most important avoidable independent determinant of glycemia in normoglycemic subjects, is critical to reduce the risk of the associated vascular disease. © 2006 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/metabolen_HK
dc.relation.ispartofMetabolism: Clinical and Experimentalen_HK
dc.subject.meshAge Factorsen_HK
dc.subject.meshAgeden_HK
dc.subject.meshAging - physiologyen_HK
dc.subject.meshAnthropometryen_HK
dc.subject.meshBlood Glucose - metabolismen_HK
dc.subject.meshBlood Pressure - physiologyen_HK
dc.subject.meshC-Reactive Protein - metabolismen_HK
dc.subject.meshChina - epidemiologyen_HK
dc.subject.meshCholesterol, HDL - blooden_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypertension - epidemiologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshProspective Studiesen_HK
dc.subject.meshRegression Analysisen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshSex Factorsen_HK
dc.subject.meshVascular Diseases - blood - epidemiologyen_HK
dc.subject.meshWaist-Hip Ratioen_HK
dc.titleAssociation of vascular risk factors with increasing glycemia even in normoglycemic subjects in an older Chinese population: the Guangzhou Biobank Cohort Studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0026-0495&volume=55&spage=1035&epage=1041&date=2006&atitle=Association+of+vascular+risk+factors+with+increasing+glycemia+even+in+normoglycemic+subjects+in+an+older+Chinese+population:+The+Guangzhou+Biobank+Cohort+Studyen_HK
dc.identifier.emailMcGhee, SM:smmcghee@hkucc.hku.hken_HK
dc.identifier.emailSchooling, M:cms1@hkucc.hku.hken_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityMcGhee, SM=rp00393en_HK
dc.identifier.authoritySchooling, M=rp00504en_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.metabol.2006.03.014en_HK
dc.identifier.pmid16839838-
dc.identifier.scopuseid_2-s2.0-33745887496en_HK
dc.identifier.hkuros121613en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745887496&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume55en_HK
dc.identifier.issue8en_HK
dc.identifier.spage1035en_HK
dc.identifier.epage1041en_HK
dc.identifier.isiWOS:000239289300008-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridThomas, GN=35465269900en_HK
dc.identifier.scopusauthoridJiang, CQ=10639500500en_HK
dc.identifier.scopusauthoridMcGhee, SM=7003288588en_HK
dc.identifier.scopusauthoridZhang, WS=13410704100en_HK
dc.identifier.scopusauthoridLao, XQ=14031637000en_HK
dc.identifier.scopusauthoridSchooling, M=12808565000en_HK
dc.identifier.scopusauthoridAdab, P=6601949045en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridCheng, KK=7402997800en_HK

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