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Article: Smoking, drinking and colorectal cancer in Hong Kong Chinese: A case-control study

TitleSmoking, drinking and colorectal cancer in Hong Kong Chinese: A case-control study
Authors
Issue Date2004
PublisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home
Citation
International Journal Of Cancer, 2004, v. 109 n. 4, p. 587-597 How to Cite?
AbstractExpert opinions differ on the causal role of cigarettes and alcohol in colorectal cancer. This study investigates such associations in Hong Kong Chinese. A hospital-based case-control study was conducted from April 1998 to March 2000. Newly diagnosed colorectal adenocarcinoma and sex- and age-matched inpatient controls without gastrointestinal and malignant conditions were included. Structured interviews were conducted using a validated questionnaire to study any association of smoking, drinking and the lifelong extent of such exposures with colorectal cancer risk. We successfully interviewed 822 cases and 926 controls. Current regular cigarette smokers had an increased rectal cancer risk (adjusted OR = 1.44; 95% CI = 1.001-2.06). Increasing tertiles of smoking duration in ever smokers was also associated with increased rectal cancer risk (p trend = 0.038). An increased risk of colorectal cancer was found in current drinkers (adjusted OR = 1.42; 95% CI = 1.09-1.85) and in those who drank ≥ 4 days (current and ex-drinkers) or > 4 units (ever and ex-drinkers) weekly. Moreover, colorectal cancer risk was found to decrease with increasing duration of drinking abstention (p trend = 0.006). This is the first report of a positive association between cigarette smoking and rectal cancer risk in a Chinese population. Current drinkers and those who drank regularly and heavily had increased colorectal cancer risk. Moreover, this study is the first to show that drinking cessation could be effective in reversing such increased risk in a duration-dependent manner. These new findings are important for cancer prevention and healthcare promotion. © 2004 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/86508
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.657
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHo, JWCen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorTse, CWen_HK
dc.contributor.authorChiu, LKMen_HK
dc.contributor.authorLam, HSen_HK
dc.contributor.authorLeung, PFen_HK
dc.contributor.authorNg, KCen_HK
dc.contributor.authorHo, SYen_HK
dc.contributor.authorWoo, Jen_HK
dc.contributor.authorLeung, SSFen_HK
dc.contributor.authorYuen, STen_HK
dc.date.accessioned2010-09-06T09:17:55Z-
dc.date.available2010-09-06T09:17:55Z-
dc.date.issued2004en_HK
dc.identifier.citationInternational Journal Of Cancer, 2004, v. 109 n. 4, p. 587-597en_HK
dc.identifier.issn0020-7136en_HK
dc.identifier.urihttp://hdl.handle.net/10722/86508-
dc.description.abstractExpert opinions differ on the causal role of cigarettes and alcohol in colorectal cancer. This study investigates such associations in Hong Kong Chinese. A hospital-based case-control study was conducted from April 1998 to March 2000. Newly diagnosed colorectal adenocarcinoma and sex- and age-matched inpatient controls without gastrointestinal and malignant conditions were included. Structured interviews were conducted using a validated questionnaire to study any association of smoking, drinking and the lifelong extent of such exposures with colorectal cancer risk. We successfully interviewed 822 cases and 926 controls. Current regular cigarette smokers had an increased rectal cancer risk (adjusted OR = 1.44; 95% CI = 1.001-2.06). Increasing tertiles of smoking duration in ever smokers was also associated with increased rectal cancer risk (p trend = 0.038). An increased risk of colorectal cancer was found in current drinkers (adjusted OR = 1.42; 95% CI = 1.09-1.85) and in those who drank ≥ 4 days (current and ex-drinkers) or > 4 units (ever and ex-drinkers) weekly. Moreover, colorectal cancer risk was found to decrease with increasing duration of drinking abstention (p trend = 0.006). This is the first report of a positive association between cigarette smoking and rectal cancer risk in a Chinese population. Current drinkers and those who drank regularly and heavily had increased colorectal cancer risk. Moreover, this study is the first to show that drinking cessation could be effective in reversing such increased risk in a duration-dependent manner. These new findings are important for cancer prevention and healthcare promotion. © 2004 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/homeen_HK
dc.relation.ispartofInternational Journal of Canceren_HK
dc.rightsInternational Journal of Cancer. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshAdenocarcinoma - epidemiology - etiologyen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshAlcohol Drinking - adverse effects - epidemiologyen_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshColonen_HK
dc.subject.meshColorectal Neoplasms - epidemiology - etiologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshInterviews as Topicen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshOdds Ratioen_HK
dc.subject.meshRectumen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshSmoking - adverse effects - epidemiologyen_HK
dc.titleSmoking, drinking and colorectal cancer in Hong Kong Chinese: A case-control studyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0020-7136&volume=109&issue=4&spage=587&epage=597&date=2004&atitle=Smoking,+drinking+and+colorectal+cancer+in+Hong+Kong+Chinese:+a+case-control+studyen_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.emailHo, SY:syho@hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.identifier.authorityHo, SY=rp00427en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/ijc.20018en_HK
dc.identifier.pmid14991582-
dc.identifier.scopuseid_2-s2.0-12144288024en_HK
dc.identifier.hkuros89591en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-12144288024&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume109en_HK
dc.identifier.issue4en_HK
dc.identifier.spage587en_HK
dc.identifier.epage597en_HK
dc.identifier.isiWOS:000220257200015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHo, JWC=7402649983en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridTse, CW=36958765600en_HK
dc.identifier.scopusauthoridChiu, LKM=36864884100en_HK
dc.identifier.scopusauthoridLam, HS=7202774916en_HK
dc.identifier.scopusauthoridLeung, PF=36873074800en_HK
dc.identifier.scopusauthoridNg, KC=36898900400en_HK
dc.identifier.scopusauthoridHo, SY=7403716884en_HK
dc.identifier.scopusauthoridWoo, J=36040369400en_HK
dc.identifier.scopusauthoridLeung, SSF=7202044842en_HK
dc.identifier.scopusauthoridYuen, ST=7103160927en_HK

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