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Article: Clustering of childhood leukaemia in Hong Kong: Association with the childhood peak and common acute lymphoblastic leukaemia and with population mixing

TitleClustering of childhood leukaemia in Hong Kong: Association with the childhood peak and common acute lymphoblastic leukaemia and with population mixing
Authors
KeywordsAcute lymphoblastic leukaemia
Childhood leukaemia
Clustering
Common infections
Epidemiology
Population mixing
Issue Date1997
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjc
Citation
British Journal Of Cancer, 1997, v. 75 n. 3, p. 457-463 How to Cite?
AbstractIncidence data of childhood leukaemia (CL) in Hong Kong (1984-90) have been analysed for evidence of variation between small areas. All cases (n = 261) were classified by morphological cell type, with the majority (n = 205) being acute lymphoblastic leukaemia (ALL), and haematological review has permitted immunophenotypic classification for 73% of these. The data have been examined for evidence of spatial clustering within small census areas (TPUs) and for association with population mixing, with attention focused on those subgroups (especially the childhood peak of ALL - taken here to be diagnoses in children from 24 months up to the seventh birthday - and common ALL) which, it has been hypothesized, may be caused by unusual patterns of exposure and response to common infections. For the whole of Hong Kong, there was evidence of spatial clustering of ALL at ages 0-4 years (P = 0.09) and in the childhood peak (P < 0.05). When these analyses were restricted to TPUs where extreme population mixing may have occurred, overall incidence was elevated and significant evidence of clustering was found for ALL (P < 0.007) at these ages and for the common ALL in the childhood peak (P = 0.032). Replication of the analyses for subsets of leukaemia that were not dominated by the childhood peak of ALL found no evidence of clustering. This is the first investigation of an association between population mixing and childhood leukaemia in Asia and the first to include clustering and to consider particular subsets. The results are supportive of the 'infectious' aetiology hypothesis for subsets of childhood leukaemia, specifically common ALL in the childhood peak.
Persistent Identifierhttp://hdl.handle.net/10722/86462
ISSN
2015 Impact Factor: 5.569
2015 SCImago Journal Rankings: 2.939
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAlexander, FEen_HK
dc.contributor.authorChan, LCen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorYuen, Pen_HK
dc.contributor.authorLeung, NKen_HK
dc.contributor.authorHa, SYen_HK
dc.contributor.authorYuen, HLen_HK
dc.contributor.authorLi, CKen_HK
dc.contributor.authorLi, CKen_HK
dc.contributor.authorLau, YLen_HK
dc.contributor.authorGreaves, MFen_HK
dc.date.accessioned2010-09-06T09:17:20Z-
dc.date.available2010-09-06T09:17:20Z-
dc.date.issued1997en_HK
dc.identifier.citationBritish Journal Of Cancer, 1997, v. 75 n. 3, p. 457-463en_HK
dc.identifier.issn0007-0920en_HK
dc.identifier.urihttp://hdl.handle.net/10722/86462-
dc.description.abstractIncidence data of childhood leukaemia (CL) in Hong Kong (1984-90) have been analysed for evidence of variation between small areas. All cases (n = 261) were classified by morphological cell type, with the majority (n = 205) being acute lymphoblastic leukaemia (ALL), and haematological review has permitted immunophenotypic classification for 73% of these. The data have been examined for evidence of spatial clustering within small census areas (TPUs) and for association with population mixing, with attention focused on those subgroups (especially the childhood peak of ALL - taken here to be diagnoses in children from 24 months up to the seventh birthday - and common ALL) which, it has been hypothesized, may be caused by unusual patterns of exposure and response to common infections. For the whole of Hong Kong, there was evidence of spatial clustering of ALL at ages 0-4 years (P = 0.09) and in the childhood peak (P < 0.05). When these analyses were restricted to TPUs where extreme population mixing may have occurred, overall incidence was elevated and significant evidence of clustering was found for ALL (P < 0.007) at these ages and for the common ALL in the childhood peak (P = 0.032). Replication of the analyses for subsets of leukaemia that were not dominated by the childhood peak of ALL found no evidence of clustering. This is the first investigation of an association between population mixing and childhood leukaemia in Asia and the first to include clustering and to consider particular subsets. The results are supportive of the 'infectious' aetiology hypothesis for subsets of childhood leukaemia, specifically common ALL in the childhood peak.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/bjcen_HK
dc.relation.ispartofBritish Journal of Canceren_HK
dc.subjectAcute lymphoblastic leukaemiaen_HK
dc.subjectChildhood leukaemiaen_HK
dc.subjectClusteringen_HK
dc.subjectCommon infectionsen_HK
dc.subjectEpidemiologyen_HK
dc.subjectPopulation mixingen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAge Factorsen_HK
dc.subject.meshAntigens, CD - blooden_HK
dc.subject.meshB-Lymphocytes - immunologyen_HK
dc.subject.meshBurkitt Lymphoma - epidemiology - immunologyen_HK
dc.subject.meshChilden_HK
dc.subject.meshChild, Preschoolen_HK
dc.subject.meshCluster Analysisen_HK
dc.subject.meshHong Kong - epidemiologyen_HK
dc.subject.meshHospital Recordsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunophenotypingen_HK
dc.subject.meshIncidenceen_HK
dc.subject.meshInfanten_HK
dc.subject.meshLeukemia - epidemiologyen_HK
dc.subject.meshLeukemia-Lymphoma, Adult T-Cell - epidemiology - immunologyen_HK
dc.subject.meshPrecursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology - immunologyen_HK
dc.titleClustering of childhood leukaemia in Hong Kong: Association with the childhood peak and common acute lymphoblastic leukaemia and with population mixingen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0007-0920&volume=75&spage=457&epage=463&date=1997&atitle=Clustering+of+childhood+leukaemia+in+Hong+Kong:+association+with+the+childhood+peak+and+common+acute+lymphoblastic+leukaemia+and+with+population+mixingen_HK
dc.identifier.emailChan, LC:chanlc@hkucc.hku.hken_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.emailLau, YL:lauylung@hkucc.hku.hken_HK
dc.identifier.authorityChan, LC=rp00373en_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.identifier.authorityLau, YL=rp00361en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid9020498en_HK
dc.identifier.scopuseid_2-s2.0-8044244825en_HK
dc.identifier.hkuros21472en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-8044244825&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume75en_HK
dc.identifier.issue3en_HK
dc.identifier.spage457en_HK
dc.identifier.epage463en_HK
dc.identifier.isiWOS:A1997WE64800026-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridAlexander, FE=7101861992en_HK
dc.identifier.scopusauthoridChan, LC=7403540707en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridYuen, P=7103124005en_HK
dc.identifier.scopusauthoridLeung, NK=7006841120en_HK
dc.identifier.scopusauthoridHa, SY=7202501115en_HK
dc.identifier.scopusauthoridYuen, HL=7103253677en_HK
dc.identifier.scopusauthoridLi, CK=19035337000en_HK
dc.identifier.scopusauthoridLi, CK=15122650100en_HK
dc.identifier.scopusauthoridLau, YL=7201403380en_HK
dc.identifier.scopusauthoridGreaves, MF=35398813200en_HK

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