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Article: The impact of cardiovascular risk factors on the age-related excess risk of coronary heart disease

TitleThe impact of cardiovascular risk factors on the age-related excess risk of coronary heart disease
Authors
Issue Date2006
PublisherOxford University Press. The Journal's web site is located at http://ije.oxfordjournals.org/
Citation
International Journal of Epidemiology, 2006, v. 35 n. 4, p. 1025-1033 How to Cite?
AbstractPURPOSE: Differences in cardiovascular risk factor levels have been suggested to contribute to the age-related excess risk of coronary heart disease (CHD). The aim of this study was to reliably quantify these contributions using a large prospective dataset. METHODS: We carried out an individual participant data meta-analysis of 41 cohort studies (n = 582,134) from Asia, and Australia and New Zealand. Cox models were used to estimate hazard ratios for coronary death, comparing individuals aged 55-64, 65-74, and >or=5 yrs with those aged <55 yrs. Adjustments were made for coronary risk factors to quantify their contributions to the age differential. RESULTS: During 4.1 million person-years of follow-up, there were 2,915 deaths from CHD. The risk of CHD increased substantially with age in all groups, especially in women. Differences in cardiovascular risk factors explained between one-quarter to one-third of the age-related excess of CHD in men and one-half of that in women. Systolic blood pressure was the chief contributor to the excess risk in all groups. CONCLUSIONS: Systolic blood pressure was the most important modifiable risk factor contributing to the excess CHD risk that occurs with aging in men and women, but in comparison with the effects of age itself, the effects of blood pressure are small.
Persistent Identifierhttp://hdl.handle.net/10722/86422
ISSN
2015 Impact Factor: 7.522
2015 SCImago Journal Rankings: 4.381
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHuxley, Ren_HK
dc.contributor.authorBarzi, Fen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorLawes, CMMen_HK
dc.contributor.authorWoo, Jen_HK
dc.contributor.authorWoodward, Men_HK
dc.date.accessioned2010-09-06T09:16:49Z-
dc.date.available2010-09-06T09:16:49Z-
dc.date.issued2006en_HK
dc.identifier.citationInternational Journal of Epidemiology, 2006, v. 35 n. 4, p. 1025-1033en_HK
dc.identifier.issn0300-5771en_HK
dc.identifier.urihttp://hdl.handle.net/10722/86422-
dc.description.abstractPURPOSE: Differences in cardiovascular risk factor levels have been suggested to contribute to the age-related excess risk of coronary heart disease (CHD). The aim of this study was to reliably quantify these contributions using a large prospective dataset. METHODS: We carried out an individual participant data meta-analysis of 41 cohort studies (n = 582,134) from Asia, and Australia and New Zealand. Cox models were used to estimate hazard ratios for coronary death, comparing individuals aged 55-64, 65-74, and >or=5 yrs with those aged <55 yrs. Adjustments were made for coronary risk factors to quantify their contributions to the age differential. RESULTS: During 4.1 million person-years of follow-up, there were 2,915 deaths from CHD. The risk of CHD increased substantially with age in all groups, especially in women. Differences in cardiovascular risk factors explained between one-quarter to one-third of the age-related excess of CHD in men and one-half of that in women. Systolic blood pressure was the chief contributor to the excess risk in all groups. CONCLUSIONS: Systolic blood pressure was the most important modifiable risk factor contributing to the excess CHD risk that occurs with aging in men and women, but in comparison with the effects of age itself, the effects of blood pressure are small.-
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://ije.oxfordjournals.org/en_HK
dc.relation.ispartofInternational Journal of Epidemiologyen_HK
dc.rightsInternational Journal of Epidemiology. Copyright © Oxford University Press.en_HK
dc.subject.meshAge Factors-
dc.subject.meshAging - physiology-
dc.subject.meshCoronary Disease - etiology-
dc.subject.meshHypertension - complications-
dc.subject.meshRisk Assessment - methods-
dc.titleThe impact of cardiovascular risk factors on the age-related excess risk of coronary heart diseaseen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0300-5771&volume=35&issue=4&spage=1025&epage=1033&date=2006&atitle=The+impact+of+cardiovascular+risk+factors+on+the+age-related+excess+risk+of+coronary+heart+diseaseen_HK
dc.identifier.emailLam, TH: hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/ije/dyl058-
dc.identifier.pmid16581818-
dc.identifier.scopuseid_2-s2.0-33749647724-
dc.identifier.hkuros168794en_HK
dc.identifier.isiWOS:000240939300035-
dc.identifier.f10001046795-
dc.identifier.citeulike867313-

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