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Article: Cigarette smoking, systolic blood pressure, and cardiovascular diseases in the asia-pacific region

TitleCigarette smoking, systolic blood pressure, and cardiovascular diseases in the asia-pacific region
Authors
Issue Date2008
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://stroke.ahajournals.org
Citation
Stroke, 2008, v. 39 n. 6, p. 1694-1702 How to Cite?
AbstractBACKGROUND AND PURPOSE: Smoking and increased levels of blood pressure (BP) substantially increase the risk of cardiovascular diseases (CVD). If these 2 risk factors have a synergistic impact on cardiovascular events, lowering BP and quitting smoking will contribute more to reducing CVD than would be expected from ignoring their interaction. METHODS: Individual participant data were combined from 41 cohorts, involving 563 144 participants (82% Asian). During a median of 6.8 years follow-up, 4344 coronary heart disease (CHD) and 5906 stroke events were recorded. Repeat measures of systolic blood pressure (SBP) were used to adjust for regression dilution bias. Hazard ratios (HRs) and 95% confidence intervals (CIs) for SBP by cigarette smoking status were estimated from Cox proportional hazard models adjusted for age and stratified by study and sex. RESULTS: Data suggested a log-linear relationship between SBP and all subtypes of CVD. The HRs relating SBP to both CHD and ischemic stroke were broadly similar irrespective of smoking status (Pĝ‰¥0.1). For hemorrhagic stroke (intracerebral hemorrhage), the HRs (95% CIs) for an additional 10 mm Hg increment in SBP were 1.81 (1.73 to 1.90) for present smokers and 1.66 (1.59 to 1.73) for nonsmokers (P≤0.003). For every subtype of cardiovascular events, similar results were found for analyses involving only fatal events. CONCLUSIONS: Smoking exacerbated the impact of SBP on the risk of hemorrhagic stroke. Although quitting smoking and lowering BP are both crucial for prevention of CVD, combining the 2 could be expected to have extra beneficial effect on preventing hemorrhagic stroke. © 2008 American Heart Association, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/86414
ISSN
2015 Impact Factor: 5.787
2015 SCImago Journal Rankings: 3.671
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNakamura, Ken_HK
dc.contributor.authorBarzi, Fen_HK
dc.contributor.authorLam, THen_HK
dc.contributor.authorHuxley, Ren_HK
dc.contributor.authorFeigin, VLen_HK
dc.contributor.authorUeshima, Hen_HK
dc.contributor.authorWoo, Jen_HK
dc.contributor.authorGu, Den_HK
dc.contributor.authorOhkubo, Ten_HK
dc.contributor.authorLawes, CMMen_HK
dc.contributor.authorSuh, Ien_HK
dc.contributor.authorWoodward, Men_HK
dc.date.accessioned2010-09-06T09:16:42Z-
dc.date.available2010-09-06T09:16:42Z-
dc.date.issued2008en_HK
dc.identifier.citationStroke, 2008, v. 39 n. 6, p. 1694-1702en_HK
dc.identifier.issn0039-2499en_HK
dc.identifier.urihttp://hdl.handle.net/10722/86414-
dc.description.abstractBACKGROUND AND PURPOSE: Smoking and increased levels of blood pressure (BP) substantially increase the risk of cardiovascular diseases (CVD). If these 2 risk factors have a synergistic impact on cardiovascular events, lowering BP and quitting smoking will contribute more to reducing CVD than would be expected from ignoring their interaction. METHODS: Individual participant data were combined from 41 cohorts, involving 563 144 participants (82% Asian). During a median of 6.8 years follow-up, 4344 coronary heart disease (CHD) and 5906 stroke events were recorded. Repeat measures of systolic blood pressure (SBP) were used to adjust for regression dilution bias. Hazard ratios (HRs) and 95% confidence intervals (CIs) for SBP by cigarette smoking status were estimated from Cox proportional hazard models adjusted for age and stratified by study and sex. RESULTS: Data suggested a log-linear relationship between SBP and all subtypes of CVD. The HRs relating SBP to both CHD and ischemic stroke were broadly similar irrespective of smoking status (Pĝ‰¥0.1). For hemorrhagic stroke (intracerebral hemorrhage), the HRs (95% CIs) for an additional 10 mm Hg increment in SBP were 1.81 (1.73 to 1.90) for present smokers and 1.66 (1.59 to 1.73) for nonsmokers (P≤0.003). For every subtype of cardiovascular events, similar results were found for analyses involving only fatal events. CONCLUSIONS: Smoking exacerbated the impact of SBP on the risk of hemorrhagic stroke. Although quitting smoking and lowering BP are both crucial for prevention of CVD, combining the 2 could be expected to have extra beneficial effect on preventing hemorrhagic stroke. © 2008 American Heart Association, Inc.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://stroke.ahajournals.orgen_HK
dc.relation.ispartofStrokeen_HK
dc.rightsStroke. Copyright © Lippincott Williams & Wilkins.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshAsia, Southeastern - epidemiologyen_HK
dc.subject.meshAsian Continental Ancestry Group - statistics & numerical dataen_HK
dc.subject.meshBlood Pressure - drug effects - physiologyen_HK
dc.subject.meshBrain Ischemia - epidemiology - ethnologyen_HK
dc.subject.meshCardiovascular Diseases - epidemiology - ethnologyen_HK
dc.subject.meshCerebral Hemorrhage - epidemiology - ethnologyen_HK
dc.subject.meshCohort Studiesen_HK
dc.subject.meshComorbidity - trendsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHypertension - epidemiology - ethnologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPacific Islands - epidemiologyen_HK
dc.subject.meshRisk Factorsen_HK
dc.subject.meshRisk Reduction Behavioren_HK
dc.subject.meshSmoking - epidemiology - ethnologyen_HK
dc.subject.meshSmoking Cessationen_HK
dc.titleCigarette smoking, systolic blood pressure, and cardiovascular diseases in the asia-pacific regionen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0039-2499&volume=39&issue=6&spage=1694&epage=1702&date=2008&atitle=Cigarette+smoking,+systolic+blood+pressure,+and+cardiovascular+diseases+in+the+Asia-Pacific+regionen_HK
dc.identifier.emailLam, TH:hrmrlth@hkucc.hku.hken_HK
dc.identifier.authorityLam, TH=rp00326en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1161/STROKEAHA.107.496752en_HK
dc.identifier.pmid18323508en_HK
dc.identifier.scopuseid_2-s2.0-46249091188en_HK
dc.identifier.hkuros142642en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-46249091188&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume39en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1694en_HK
dc.identifier.epage1702en_HK
dc.identifier.isiWOS:000256162600013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridNakamura, K=11139298500en_HK
dc.identifier.scopusauthoridBarzi, F=7003545543en_HK
dc.identifier.scopusauthoridLam, TH=7202522876en_HK
dc.identifier.scopusauthoridHuxley, R=6701828350en_HK
dc.identifier.scopusauthoridFeigin, VL=7005173210en_HK
dc.identifier.scopusauthoridUeshima, H=7005129002en_HK
dc.identifier.scopusauthoridWoo, J=36040369400en_HK
dc.identifier.scopusauthoridGu, D=7202151958en_HK
dc.identifier.scopusauthoridOhkubo, T=7201618716en_HK
dc.identifier.scopusauthoridLawes, CMM=6602516713en_HK
dc.identifier.scopusauthoridSuh, I=7101988200en_HK
dc.identifier.scopusauthoridWoodward, M=7102510958en_HK
dc.identifier.citeulike3140116-

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