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Article: Buyang Huanwu Decoction can improve recovery of neurological function, reduce infarction volume, stimulate neural proliferation and modulate VEGF and Flk1 expressions in transient focal cerebral ischaemic rat brains

TitleBuyang Huanwu Decoction can improve recovery of neurological function, reduce infarction volume, stimulate neural proliferation and modulate VEGF and Flk1 expressions in transient focal cerebral ischaemic rat brains
Authors
KeywordsBuyang Huanwu Decoction
Flk1
Focal cerebral ischaemia
Proliferation
VEGF
Issue Date2007
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jethpharm
Citation
Journal Of Ethnopharmacology, 2007, v. 113 n. 2, p. 292-299 How to Cite?
AbstractBuyang Huanwu Decoction is a classic formula for treating stroke-induced disability in traditional Chinese medicine (TCM). To explore its pharmacological basis, we investigated the effects of the whole formula and its herbal components on the neurological behavior performance and infarction volume in focal cerebral ischaemia rats. The neurological deficit scores and infarction volume were measured at days 3, 7 and 14 after 30 min of occlusion of middle cerebral artery. The results showed that Buyang Huanwu Decoction and its herbal components significantly improved the neurological behavior performances and reduced the infarction volume in the ischaemic brains. To elucidate the potential therapeutic mechanisms, we investigated the proliferation of progenitors by detecting the immunohistochemical staining of thymidine analog 5-bromo-2′-deoxyuridine (BrdU) and found that the formula stimulated the proliferation of the progenitors at hippocampus and subventricular zone (SVZ) in the ischaemic brains. As vascular endothelial growth factor (VEGF) and its receptor fetal liver kinase (Flk1) are important neurotrophic, neuroprotective and neuroproliferative factors, we studied the expressions of VEGF and Flk1 in the hippocampus, SVZ and cortex in the ischaemic brains and found that the formula led to increase the numbers of VEGF-positive and Flk1-positive cells in the SVZ and cortex in the ischaemic brains. The results indicate that the therapeutic effects of Buyang Huanwu Decoction for recovery of neurological deficits are associated with the stimulation of the proliferation of progenitors and the enhancement of the expressions of VEGF and Flk in ischaemic brains. © 2007 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/85514
ISSN
2015 Impact Factor: 3.055
2015 SCImago Journal Rankings: 1.156
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCai, Gen_HK
dc.contributor.authorLiu, Ben_HK
dc.contributor.authorLiu, Wen_HK
dc.contributor.authorTan, Xen_HK
dc.contributor.authorRong, Jen_HK
dc.contributor.authorChen, Xen_HK
dc.contributor.authorTong, Len_HK
dc.contributor.authorShen, Jen_HK
dc.date.accessioned2010-09-06T09:05:58Z-
dc.date.available2010-09-06T09:05:58Z-
dc.date.issued2007en_HK
dc.identifier.citationJournal Of Ethnopharmacology, 2007, v. 113 n. 2, p. 292-299en_HK
dc.identifier.issn0378-8741en_HK
dc.identifier.urihttp://hdl.handle.net/10722/85514-
dc.description.abstractBuyang Huanwu Decoction is a classic formula for treating stroke-induced disability in traditional Chinese medicine (TCM). To explore its pharmacological basis, we investigated the effects of the whole formula and its herbal components on the neurological behavior performance and infarction volume in focal cerebral ischaemia rats. The neurological deficit scores and infarction volume were measured at days 3, 7 and 14 after 30 min of occlusion of middle cerebral artery. The results showed that Buyang Huanwu Decoction and its herbal components significantly improved the neurological behavior performances and reduced the infarction volume in the ischaemic brains. To elucidate the potential therapeutic mechanisms, we investigated the proliferation of progenitors by detecting the immunohistochemical staining of thymidine analog 5-bromo-2′-deoxyuridine (BrdU) and found that the formula stimulated the proliferation of the progenitors at hippocampus and subventricular zone (SVZ) in the ischaemic brains. As vascular endothelial growth factor (VEGF) and its receptor fetal liver kinase (Flk1) are important neurotrophic, neuroprotective and neuroproliferative factors, we studied the expressions of VEGF and Flk1 in the hippocampus, SVZ and cortex in the ischaemic brains and found that the formula led to increase the numbers of VEGF-positive and Flk1-positive cells in the SVZ and cortex in the ischaemic brains. The results indicate that the therapeutic effects of Buyang Huanwu Decoction for recovery of neurological deficits are associated with the stimulation of the proliferation of progenitors and the enhancement of the expressions of VEGF and Flk in ischaemic brains. © 2007 Elsevier Ireland Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/jethpharmen_HK
dc.relation.ispartofJournal of Ethnopharmacologyen_HK
dc.rightsJournal of Ethnopharmacology. Copyright © Elsevier Ireland Ltd.en_HK
dc.subjectBuyang Huanwu Decoctionen_HK
dc.subjectFlk1en_HK
dc.subjectFocal cerebral ischaemiaen_HK
dc.subjectProliferationen_HK
dc.subjectVEGFen_HK
dc.titleBuyang Huanwu Decoction can improve recovery of neurological function, reduce infarction volume, stimulate neural proliferation and modulate VEGF and Flk1 expressions in transient focal cerebral ischaemic rat brainsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0378-8741&volume=113&spage=292&epage=299&date=2007&atitle=Buyang+Huanwu+Decoction+Can+Improve+Recovery+of+Neurological+Function,+Reduce+Infarction+Volume,+Stimulate+Neural+Proliferation+and+Modulate+VEGF+and+Flk1+Expressions+in+Transient+Focal+Cerebral+Ischaemic+Rat+Brainsen_HK
dc.identifier.emailRong, J: jrong@hku.hken_HK
dc.identifier.emailShen, J: shenjg@hku.hken_HK
dc.identifier.authorityRong, J=rp00515en_HK
dc.identifier.authorityShen, J=rp00487en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jep.2007.06.007en_HK
dc.identifier.pmid17692486en_HK
dc.identifier.scopuseid_2-s2.0-34547821365en_HK
dc.identifier.hkuros130748en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34547821365&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume113en_HK
dc.identifier.issue2en_HK
dc.identifier.spage292en_HK
dc.identifier.epage299en_HK
dc.identifier.isiWOS:000249456900015-
dc.publisher.placeIrelanden_HK
dc.identifier.scopusauthoridCai, G=24480333700en_HK
dc.identifier.scopusauthoridLiu, B=19736036400en_HK
dc.identifier.scopusauthoridLiu, W=36077269600en_HK
dc.identifier.scopusauthoridTan, X=24068123000en_HK
dc.identifier.scopusauthoridRong, J=7005980047en_HK
dc.identifier.scopusauthoridChen, X=15031407900en_HK
dc.identifier.scopusauthoridTong, L=7201891650en_HK
dc.identifier.scopusauthoridShen, J=7404929947en_HK

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