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Article: Ethical, legal and social implications of prenatal and preimplantation genetic testing for cancer susceptibility

TitleEthical, legal and social implications of prenatal and preimplantation genetic testing for cancer susceptibility
Authors
KeywordsEthical implications
Genetic counselling
Hereditary cancer syndrome
PGD
Prenatal genetic testing
Issue Date2009
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/721149/description#description
Citation
Reproductive Biomedicine Online, 2009, v. 19 SUPPL. 2, p. 23-33 How to Cite?
AbstractWith the progress in cancer genetics and assisted reproductive technologies, it is now possible for cancer gene mutation carriers not only to reduce cancer mortality through the targeting of surveillance and preventive therapies, but also to avoid the birth of at-risk babies through the choice of different means of reproduction. Thus, the incidence of hereditary cancer syndromes may be decreased in the future. The integration of cancer genetic testing and assisted reproductive technologies raises certain ethical, legal and social issues beyond either genetic testing or assisted reproductive technology itself. In this paper, the reproductive decisions/choices of at-risk young couples and the ethical, legal and social concerns of prenatal genetic testing and preimplantation genetic diagnosis for susceptibility to hereditary cancer syndromes are discussed. Specifically, three ethical principles related to the integration of cancer genetic testing and assisted reproductive technologies, i.e. informed choice, beneficence to children and social justice, and their implications for the responsible translation of these medical techniques into common practice of preventive medicine are highlighted.
Persistent Identifierhttp://hdl.handle.net/10722/85504
ISSN
2015 Impact Factor: 2.796
2015 SCImago Journal Rankings: 1.459
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, CWen_HK
dc.contributor.authorHui, ECen_HK
dc.date.accessioned2010-09-06T09:05:51Z-
dc.date.available2010-09-06T09:05:51Z-
dc.date.issued2009en_HK
dc.identifier.citationReproductive Biomedicine Online, 2009, v. 19 SUPPL. 2, p. 23-33en_HK
dc.identifier.issn1472-6483en_HK
dc.identifier.urihttp://hdl.handle.net/10722/85504-
dc.description.abstractWith the progress in cancer genetics and assisted reproductive technologies, it is now possible for cancer gene mutation carriers not only to reduce cancer mortality through the targeting of surveillance and preventive therapies, but also to avoid the birth of at-risk babies through the choice of different means of reproduction. Thus, the incidence of hereditary cancer syndromes may be decreased in the future. The integration of cancer genetic testing and assisted reproductive technologies raises certain ethical, legal and social issues beyond either genetic testing or assisted reproductive technology itself. In this paper, the reproductive decisions/choices of at-risk young couples and the ethical, legal and social concerns of prenatal genetic testing and preimplantation genetic diagnosis for susceptibility to hereditary cancer syndromes are discussed. Specifically, three ethical principles related to the integration of cancer genetic testing and assisted reproductive technologies, i.e. informed choice, beneficence to children and social justice, and their implications for the responsible translation of these medical techniques into common practice of preventive medicine are highlighted.en_HK
dc.languageengen_HK
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/721149/description#descriptionen_HK
dc.relation.ispartofReproductive BioMedicine Onlineen_HK
dc.subjectEthical implicationsen_HK
dc.subjectGenetic counsellingen_HK
dc.subjectHereditary cancer syndromeen_HK
dc.subjectPGDen_HK
dc.subjectPrenatal genetic testingen_HK
dc.subject.meshGenetic Predisposition to Disease-
dc.subject.meshNeoplasms - diagnosis - genetics - prevention and control-
dc.subject.meshPreimplantation Diagnosis - ethics-
dc.subject.meshPrenatal Diagnosis - ethics-
dc.subject.meshReproductive Techniques, Assisted - ethics - legislation and jurisprudence-
dc.titleEthical, legal and social implications of prenatal and preimplantation genetic testing for cancer susceptibilityen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1472-6483&volume= 19 Supplement 2&spage=&epage=&date=2009&atitle=Ethical,+Legal,+Social+Implications+of+prenatal+and+preimplantation+genetic+testing+for+cancer+susceptibilityen_HK
dc.identifier.emailHui, EC: edwinhui@hkucc.hku.hken_HK
dc.identifier.authorityHui, EC=rp00472en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S1472-6483(10)60274-Xen_HK
dc.identifier.pmid19891845-
dc.identifier.scopuseid_2-s2.0-71949108420en_HK
dc.identifier.hkuros171282en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-71949108420&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume19en_HK
dc.identifier.issueSUPPL. 2en_HK
dc.identifier.spage23en_HK
dc.identifier.epage33en_HK
dc.identifier.isiWOS:000272208400004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridWang, CW=23996190500en_HK
dc.identifier.scopusauthoridHui, EC=35319968700en_HK

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