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Article: Protein tyrosine kinase-dependent modulation of voltage-dependent potassium channels by genistein in rat cardiac ventricular myocytes

TitleProtein tyrosine kinase-dependent modulation of voltage-dependent potassium channels by genistein in rat cardiac ventricular myocytes
Authors
Issue Date2004
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cellsig
Citation
Cellular Signalling, 2004, v. 16 n. 3, p. 333-341 How to Cite?
AbstractEffects of the isoflavone protein tyrosine kinase (PTK) inhibitor genistein on voltage-dependent K + currents, i.e., transient outward K + current (I to), sustained K + current (I ss), and inward rectifier K + current (I K1) were studied in rat cardiac ventricular myocytes. It was found that I to was reversibly inhibited by genistein in a concentration- dependent manner (IC 50=28.1 μM), while I ss was suppressed by genistein with IC 50 of 18.5 μM. In addition, I K1 (at -50 mV) was significantly decreased by 36.3±4.4% with 25 μM genistein. The inhibition of I to, I ss, and I K1 by genistein was significantly reversed by the application of the protein tyrosine phosphatase inhibitor sodium orthovanadate (1 mM). However, I to, I ss, and I K1 were not affected by the non-isoflavone PTK inhibitor tyrphostin A23 (100 μM) and PP2 (1 μM). These results indicate that activation of I to, I ss, and I K1 channels is modulated by genistein-sensitive PTKs in rat ventricular myocytes. © 2003 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/85477
ISSN
2015 Impact Factor: 4.191
2015 SCImago Journal Rankings: 2.289
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGao, Zen_HK
dc.contributor.authorLau, CPen_HK
dc.contributor.authorWong, TMen_HK
dc.contributor.authorLi, GRen_HK
dc.date.accessioned2010-09-06T09:05:31Z-
dc.date.available2010-09-06T09:05:31Z-
dc.date.issued2004en_HK
dc.identifier.citationCellular Signalling, 2004, v. 16 n. 3, p. 333-341en_HK
dc.identifier.issn0898-6568en_HK
dc.identifier.urihttp://hdl.handle.net/10722/85477-
dc.description.abstractEffects of the isoflavone protein tyrosine kinase (PTK) inhibitor genistein on voltage-dependent K + currents, i.e., transient outward K + current (I to), sustained K + current (I ss), and inward rectifier K + current (I K1) were studied in rat cardiac ventricular myocytes. It was found that I to was reversibly inhibited by genistein in a concentration- dependent manner (IC 50=28.1 μM), while I ss was suppressed by genistein with IC 50 of 18.5 μM. In addition, I K1 (at -50 mV) was significantly decreased by 36.3±4.4% with 25 μM genistein. The inhibition of I to, I ss, and I K1 by genistein was significantly reversed by the application of the protein tyrosine phosphatase inhibitor sodium orthovanadate (1 mM). However, I to, I ss, and I K1 were not affected by the non-isoflavone PTK inhibitor tyrphostin A23 (100 μM) and PP2 (1 μM). These results indicate that activation of I to, I ss, and I K1 channels is modulated by genistein-sensitive PTKs in rat ventricular myocytes. © 2003 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/cellsigen_HK
dc.relation.ispartofCellular Signallingen_HK
dc.rightsCellular Signalling. Copyright © Elsevier Inc.en_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshEnzyme Inhibitors - pharmacologyen_HK
dc.subject.meshGenistein - pharmacologyen_HK
dc.subject.meshHeart Ventricles - cytology - metabolismen_HK
dc.subject.meshKineticsen_HK
dc.subject.meshMyocytes, Cardiac - metabolismen_HK
dc.subject.meshPotassium Channels, Voltage-Gated - metabolismen_HK
dc.subject.meshProtein-Tyrosine Kinases - metabolismen_HK
dc.subject.meshRatsen_HK
dc.subject.meshVanadates - pharmacologyen_HK
dc.titleProtein tyrosine kinase-dependent modulation of voltage-dependent potassium channels by genistein in rat cardiac ventricular myocytesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0898-6568&volume=16&issue=3&spage=333&epage=341&date=2004&atitle=Protein+tyrosine+kinase-dependent+modulation+of+voltage-dependent+potassium+channels+by+genistein+in+rat+cardiac+ventricular+myocytesen_HK
dc.identifier.emailLi, GR:grli@hkucc.hku.hken_HK
dc.identifier.authorityLi, GR=rp00476en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.cellsig.2003.08.003en_HK
dc.identifier.pmid14687663-
dc.identifier.scopuseid_2-s2.0-0347627268en_HK
dc.identifier.hkuros88554en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0347627268&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issue3en_HK
dc.identifier.spage333en_HK
dc.identifier.epage341en_HK
dc.identifier.isiWOS:000187967900005-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridGao, Z=16549711200en_HK
dc.identifier.scopusauthoridLau, CP=7401968501en_HK
dc.identifier.scopusauthoridWong, TM=7403531434en_HK
dc.identifier.scopusauthoridLi, GR=7408462932en_HK

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