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Article: No evidence of an effect of alterations in dietary fatty acids on fasting adiponectin over 3 weeks

TitleNo evidence of an effect of alterations in dietary fatty acids on fasting adiponectin over 3 weeks
Authors
Issue Date2008
PublisherNorth American Association for the Study of Obesity. The Journal's web site is located at http://www.obesityresearch.org
Citation
Obesity, 2008, v. 16 n. 3, p. 592-599 How to Cite?
AbstractObjective:Little is known about the effects of alterations in fatty acid classes on adiponectin, a hormone secreted by the adipocyte known to be important in the development of diabetes and cardiovascular disease (CVD). Any factor, including diet, that may positively influence adiponectin gene expression or increase circulating levels might be useful for improving such metabolic abnormalities. We investigated the effects of alterations in dietary fatty acid saturation on fasting serum adiponectin and associated peptides.Methods and Procedures:Double-blind, randomized, crossover, 2 × 3-week residential intervention trial where 18 mildly hyperlipidemic adult men were provided with a high saturated:unsaturated fat (SFA:USFA) and lower SFA:USFA treatment separated by an uncontrolled 4-week washout. Only fatty acid profile was altered between treatments. Fasting blood samples were collected on days 0, 1, 7, 14, 21, 22 of each intervention period for the measurement of adiponectin, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsC-RP), leptin, and ghrelin.Results:Body weight was kept constant (±1 kg) throughout each treatment. There was no detectable difference in fasting adiponectin at baseline (mean day 0 day 1) between the treatment groups (mean ± s.d.; high(SFA:USFA) 7.0 ± 1.7 vs. low(SFA:USFA) 6.7 ± 1.4 g/ml, P > 0.05). There were neither significant between-treatment effects of fatty acid saturation (diet × time, P > 0.05) on serum adiponectin nor any significant between-treatment effects on serum TNF-α, IL-6, hsC-RP, leptin, or ghrelin (P > 0.05).Discussion:Fasting serum adiponectin was not detectably affected by alterations in dietary fatty acid profile in mildly hyperlipidemic men. There was no evidence that an increase in SFA content of the diet significantly worsened fasting serum adiponectin over a 3-week intervention period. © 2008 The Obesity Society.
Persistent Identifierhttp://hdl.handle.net/10722/85467
ISSN
2015 Impact Factor: 3.614
2015 SCImago Journal Rankings: 2.016
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLithander, FEen_HK
dc.contributor.authorKeogh, GFen_HK
dc.contributor.authorWang, Yen_HK
dc.contributor.authorCooper, GJSen_HK
dc.contributor.authorMulvey, TBen_HK
dc.contributor.authorChan, YKen_HK
dc.contributor.authorMcArdle, BHen_HK
dc.contributor.authorPoppitt, SDen_HK
dc.date.accessioned2010-09-06T09:05:16Z-
dc.date.available2010-09-06T09:05:16Z-
dc.date.issued2008en_HK
dc.identifier.citationObesity, 2008, v. 16 n. 3, p. 592-599en_HK
dc.identifier.issn1930-7381en_HK
dc.identifier.urihttp://hdl.handle.net/10722/85467-
dc.description.abstractObjective:Little is known about the effects of alterations in fatty acid classes on adiponectin, a hormone secreted by the adipocyte known to be important in the development of diabetes and cardiovascular disease (CVD). Any factor, including diet, that may positively influence adiponectin gene expression or increase circulating levels might be useful for improving such metabolic abnormalities. We investigated the effects of alterations in dietary fatty acid saturation on fasting serum adiponectin and associated peptides.Methods and Procedures:Double-blind, randomized, crossover, 2 × 3-week residential intervention trial where 18 mildly hyperlipidemic adult men were provided with a high saturated:unsaturated fat (SFA:USFA) and lower SFA:USFA treatment separated by an uncontrolled 4-week washout. Only fatty acid profile was altered between treatments. Fasting blood samples were collected on days 0, 1, 7, 14, 21, 22 of each intervention period for the measurement of adiponectin, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsC-RP), leptin, and ghrelin.Results:Body weight was kept constant (±1 kg) throughout each treatment. There was no detectable difference in fasting adiponectin at baseline (mean day 0 day 1) between the treatment groups (mean ± s.d.; high(SFA:USFA) 7.0 ± 1.7 vs. low(SFA:USFA) 6.7 ± 1.4 g/ml, P > 0.05). There were neither significant between-treatment effects of fatty acid saturation (diet × time, P > 0.05) on serum adiponectin nor any significant between-treatment effects on serum TNF-α, IL-6, hsC-RP, leptin, or ghrelin (P > 0.05).Discussion:Fasting serum adiponectin was not detectably affected by alterations in dietary fatty acid profile in mildly hyperlipidemic men. There was no evidence that an increase in SFA content of the diet significantly worsened fasting serum adiponectin over a 3-week intervention period. © 2008 The Obesity Society.en_HK
dc.languageengen_HK
dc.publisherNorth American Association for the Study of Obesity. The Journal's web site is located at http://www.obesityresearch.orgen_HK
dc.relation.ispartofObesityen_HK
dc.titleNo evidence of an effect of alterations in dietary fatty acids on fasting adiponectin over 3 weeksen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1930-7381&volume=&spage=&epage=&date=2008&atitle=No+Evidence+of+an+Effect+of+Alterations+in Dietary+Fatty+Acids+on+Fasting+Adiponectin Over+3+Weeksen_HK
dc.identifier.emailWang, Y: yuwanghk@hku.hken_HK
dc.identifier.authorityWang, Y=rp00239en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/oby.2007.97en_HK
dc.identifier.pmid18239552-
dc.identifier.scopuseid_2-s2.0-40149106452en_HK
dc.identifier.hkuros140352en_HK
dc.identifier.volume16en_HK
dc.identifier.issue3en_HK
dc.identifier.spage592en_HK
dc.identifier.epage599en_HK
dc.identifier.isiWOS:000253823400013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLithander, FE=23489547400en_HK
dc.identifier.scopusauthoridKeogh, GF=7004386410en_HK
dc.identifier.scopusauthoridWang, Y=34973733700en_HK
dc.identifier.scopusauthoridCooper, GJS=7402355946en_HK
dc.identifier.scopusauthoridMulvey, TB=7003519653en_HK
dc.identifier.scopusauthoridChan, YK=8613931200en_HK
dc.identifier.scopusauthoridMcArdle, BH=7005760191en_HK
dc.identifier.scopusauthoridPoppitt, SD=7004592052en_HK

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