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Article: In vivo study of microbubbles as an MR susceptibility contrast agent

TitleIn vivo study of microbubbles as an MR susceptibility contrast agent
Authors
Issue Date2004
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0740-3194/
Citation
Magnetic Resonance In Medicine, 2004, v. 52 n. 3, p. 445-452 How to Cite?
AbstractThe potential application of gas microbubbles as a unique intravascular susceptibility contrast agent for MRI has not been fully explored. In this study, the MR susceptibility effect of an ultrasound microbubble contrast agent, Optison®, was studied with rat liver imaging at 7 T. Optison® suspension in two different doses (0.15 mL/kg and 0.4 mL/kg) was injected into rats, and induced transverse relaxation rate increases (ΔR 2*) of 29.1 ± 1.6 s -1 (N = 2) and 61.5 ± 12.9 s -1 (N = 6), respectively, in liver tissue. Liver uptake of intact albumin microbubbles was observed 10 min after injection. Eight of the 16 rats studied showed no susceptibility enhancement. This is probably attributable to the intravascular microbubble growth due to transmural CO 2 supersaturation in the cecum and colon in small animals that causes microbubble aggregation and trapping in the inferior vena cava (IVC). In vitro ΔR 2* measurements of Optison® suspension at different concentrations are also reported. © 2004 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/85442
ISSN
2015 Impact Factor: 3.782
2015 SCImago Journal Rankings: 2.197
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWong, KKen_HK
dc.contributor.authorHuang, Ien_HK
dc.contributor.authorKim, YRen_HK
dc.contributor.authorTang, Hen_HK
dc.contributor.authorYang, ESen_HK
dc.contributor.authorKwong, KKen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2010-09-06T09:04:50Z-
dc.date.available2010-09-06T09:04:50Z-
dc.date.issued2004en_HK
dc.identifier.citationMagnetic Resonance In Medicine, 2004, v. 52 n. 3, p. 445-452en_HK
dc.identifier.issn0740-3194en_HK
dc.identifier.urihttp://hdl.handle.net/10722/85442-
dc.description.abstractThe potential application of gas microbubbles as a unique intravascular susceptibility contrast agent for MRI has not been fully explored. In this study, the MR susceptibility effect of an ultrasound microbubble contrast agent, Optison®, was studied with rat liver imaging at 7 T. Optison® suspension in two different doses (0.15 mL/kg and 0.4 mL/kg) was injected into rats, and induced transverse relaxation rate increases (ΔR 2*) of 29.1 ± 1.6 s -1 (N = 2) and 61.5 ± 12.9 s -1 (N = 6), respectively, in liver tissue. Liver uptake of intact albumin microbubbles was observed 10 min after injection. Eight of the 16 rats studied showed no susceptibility enhancement. This is probably attributable to the intravascular microbubble growth due to transmural CO 2 supersaturation in the cecum and colon in small animals that causes microbubble aggregation and trapping in the inferior vena cava (IVC). In vitro ΔR 2* measurements of Optison® suspension at different concentrations are also reported. © 2004 Wiley-Liss, Inc.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0740-3194/en_HK
dc.relation.ispartofMagnetic Resonance in Medicineen_HK
dc.rightsMagnetic Resonance in Medicine. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshAlbumins - administration & dosage - pharmacokineticsen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshContrast Media - administration & dosage - pharmacokineticsen_HK
dc.subject.meshFerumoxytolen_HK
dc.subject.meshFluorocarbons - administration & dosage - pharmacokineticsen_HK
dc.subject.meshIron - administration & dosageen_HK
dc.subject.meshLiver - metabolismen_HK
dc.subject.meshMagnetic Resonance Imagingen_HK
dc.subject.meshMicrospheresen_HK
dc.subject.meshOxides - administration & dosageen_HK
dc.subject.meshPhantoms, Imagingen_HK
dc.subject.meshRatsen_HK
dc.titleIn vivo study of microbubbles as an MR susceptibility contrast agenten_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0740-3194&volume=52&spage=445&epage=452&date=2004&atitle=In+Vivo+Study+of+Microbubbles+As+an+MR+Susceptibility+Contrast+Agenten_HK
dc.identifier.emailYang, ES:esyang@hkueee.hku.hken_HK
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authorityYang, ES=rp00199en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/mrm.20181en_HK
dc.identifier.pmid15334560-
dc.identifier.scopuseid_2-s2.0-4243111772en_HK
dc.identifier.hkuros94296en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4243111772&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume52en_HK
dc.identifier.issue3en_HK
dc.identifier.spage445en_HK
dc.identifier.epage452en_HK
dc.identifier.isiWOS:000223529200001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWong, KK=35222708000en_HK
dc.identifier.scopusauthoridHuang, I=36107950400en_HK
dc.identifier.scopusauthoridKim, YR=7410208445en_HK
dc.identifier.scopusauthoridTang, H=36827331000en_HK
dc.identifier.scopusauthoridYang, ES=7202021229en_HK
dc.identifier.scopusauthoridKwong, KK=7103035423en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK

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