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Article: Production and evaluation of biodegradable composites based on PHB-PHV copolymer

TitleProduction and evaluation of biodegradable composites based on PHB-PHV copolymer
Authors
Issue Date2002
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterials
Citation
Biomaterials, 2002, v. 23 n. 13, p. 2631-2639 How to Cite?
AbstractIn recent years, emphasis in biomaterials engineering has moved from materials that remain stable in the biological environment to materials that can degrade in the human body. Biodegradable materials are designed to degrade gradually and be replaced eventually by newly formed tissue in the body. In this investigation, two particulate bioactive ceramics, i.e., hydroxyapatite (HA) and tricalcium phosphate (TCP), were incorporated into polyhydroxybutyrate-polyhydroxyvalerate (PHB-PHV), which is a biodegradable copolymer, to produce new biomaterials for potential medical applications. All raw materials were commercially available and they were characterised prior to composite production. HA/PHB-PHV and TCP/PHB-PHV composites containing up to 30vol% of the bioceramics were produced through an established procedure. Compounded and compression moulded materials were evaluated using various techniques including thermogravimatric analysis, scanning electron microscopy, differential scanning calorimetry and dynamic mechanical analysis. The results showed that intended compositions of composites had been achieved and bioceramic particles were well distributed in the polymer. The degradation temperature of PHB-PHV was significantly reduced by the incorporation of bioceramics, while the melting temperature was slightly affected by the addition of bioceramics. The crystallinity of PHB-PHV was also varied with the presence of HA or TCP particles. The storage modulus and loss modulus of the composites increased with the increase in HA or TCP content. Composites containing the highest percentage of bioceramics exhibited the highest stiffness. Preliminary in vitro study indicated enhanced ability of the composites to induce the formation of bone-like apatite on their surfaces. © 2002 Elsevier Science Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/85433
ISSN
2015 Impact Factor: 8.387
2015 SCImago Journal Rankings: 3.565
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, LJen_HK
dc.contributor.authorWang, Men_HK
dc.date.accessioned2010-09-06T09:04:43Z-
dc.date.available2010-09-06T09:04:43Z-
dc.date.issued2002en_HK
dc.identifier.citationBiomaterials, 2002, v. 23 n. 13, p. 2631-2639en_HK
dc.identifier.issn0142-9612en_HK
dc.identifier.urihttp://hdl.handle.net/10722/85433-
dc.description.abstractIn recent years, emphasis in biomaterials engineering has moved from materials that remain stable in the biological environment to materials that can degrade in the human body. Biodegradable materials are designed to degrade gradually and be replaced eventually by newly formed tissue in the body. In this investigation, two particulate bioactive ceramics, i.e., hydroxyapatite (HA) and tricalcium phosphate (TCP), were incorporated into polyhydroxybutyrate-polyhydroxyvalerate (PHB-PHV), which is a biodegradable copolymer, to produce new biomaterials for potential medical applications. All raw materials were commercially available and they were characterised prior to composite production. HA/PHB-PHV and TCP/PHB-PHV composites containing up to 30vol% of the bioceramics were produced through an established procedure. Compounded and compression moulded materials were evaluated using various techniques including thermogravimatric analysis, scanning electron microscopy, differential scanning calorimetry and dynamic mechanical analysis. The results showed that intended compositions of composites had been achieved and bioceramic particles were well distributed in the polymer. The degradation temperature of PHB-PHV was significantly reduced by the incorporation of bioceramics, while the melting temperature was slightly affected by the addition of bioceramics. The crystallinity of PHB-PHV was also varied with the presence of HA or TCP particles. The storage modulus and loss modulus of the composites increased with the increase in HA or TCP content. Composites containing the highest percentage of bioceramics exhibited the highest stiffness. Preliminary in vitro study indicated enhanced ability of the composites to induce the formation of bone-like apatite on their surfaces. © 2002 Elsevier Science Ltd. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/biomaterialsen_HK
dc.relation.ispartofBiomaterialsen_HK
dc.rightsBiomaterials. Copyright © Elsevier BV.en_HK
dc.subject.meshApatites - chemistryen_HK
dc.subject.meshBiocompatible Materials - chemistry - pharmacologyen_HK
dc.subject.meshBiodegradation, Environmentalen_HK
dc.subject.meshCalorimetry, Differential Scanningen_HK
dc.subject.meshCeramicsen_HK
dc.subject.meshMicroscopy, Electron, Scanningen_HK
dc.subject.meshPolyesters - chemistry - pharmacologyen_HK
dc.subject.meshTemperatureen_HK
dc.titleProduction and evaluation of biodegradable composites based on PHB-PHV copolymeren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0142-9612&volume=23&spage=2631&epage=2639&date=2002&atitle=Production+and+evaluation+of+biodegradable+composites+based+on+PHB-PHV+copolymeren_HK
dc.identifier.emailWang, M:memwang@hku.hken_HK
dc.identifier.authorityWang, M=rp00185en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S0142-9612(01)00394-5en_HK
dc.identifier.pmid12059012-
dc.identifier.scopuseid_2-s2.0-0036234676en_HK
dc.identifier.hkuros110854en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036234676&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue13en_HK
dc.identifier.spage2631en_HK
dc.identifier.epage2639en_HK
dc.identifier.isiWOS:000175718600002-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridChen, LJ=7409439036en_HK
dc.identifier.scopusauthoridWang, M=15749714100en_HK

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