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Article: Accelerated formation of bone-like apatite on biodegradable polymer substrates

TitleAccelerated formation of bone-like apatite on biodegradable polymer substrates
Authors
KeywordsBiodegradable polymer
Biomimetics
Bone-like apatite
Simulated body fluid
Issue Date2005
PublisherTrans Tech Publications Ltd. The Journal's web site is located at http://www.scientific.net
Citation
Key Engineering Materials, 2005, v. 284-286, p. 509-512 How to Cite?
AbstractUsing an acellular simulated body fluid (SBF), bone-like apatite can be formed on a variety of biomaterials, bioactive or bioinert, after these materials have undergone appropriate treatment(s). This biomimetic apatite-forming process is now applied to tissue engineering scaffolds in an attempt to make the scaffolds osteoconductive. In the current investigation, to form bone-like apatite on polymers such as poly(L-lactic acid) (PLLA) and poly(glycolic acid) (PGA) which degrade fast in aqueous environment, a solution (SSBF) of five times the ion concentrations of SBF was used so that an accelerated apatite formation could be achieved on PLLA and PGA. It was shown that indeed apatite could be formed on PLLA and PGA in 5SBF within 24 hours and that the apatite formed in 5SBF was similar in morphology and composition to that formed in the classical biomimetic process employing SBF or 2SBF. Results obtained in this investigation are very useful for producing osteoconductive scaffolds for bone tissue engineering.
Persistent Identifierhttp://hdl.handle.net/10722/85422
ISSN
2005 Impact Factor: 0.224
2015 SCImago Journal Rankings: 0.173
References

 

DC FieldValueLanguage
dc.contributor.authorChen, Yen_HK
dc.contributor.authorMak, AFTen_HK
dc.contributor.authorWang, Men_HK
dc.date.accessioned2010-09-06T09:04:34Z-
dc.date.available2010-09-06T09:04:34Z-
dc.date.issued2005en_HK
dc.identifier.citationKey Engineering Materials, 2005, v. 284-286, p. 509-512en_HK
dc.identifier.issn1013-9826en_HK
dc.identifier.urihttp://hdl.handle.net/10722/85422-
dc.description.abstractUsing an acellular simulated body fluid (SBF), bone-like apatite can be formed on a variety of biomaterials, bioactive or bioinert, after these materials have undergone appropriate treatment(s). This biomimetic apatite-forming process is now applied to tissue engineering scaffolds in an attempt to make the scaffolds osteoconductive. In the current investigation, to form bone-like apatite on polymers such as poly(L-lactic acid) (PLLA) and poly(glycolic acid) (PGA) which degrade fast in aqueous environment, a solution (SSBF) of five times the ion concentrations of SBF was used so that an accelerated apatite formation could be achieved on PLLA and PGA. It was shown that indeed apatite could be formed on PLLA and PGA in 5SBF within 24 hours and that the apatite formed in 5SBF was similar in morphology and composition to that formed in the classical biomimetic process employing SBF or 2SBF. Results obtained in this investigation are very useful for producing osteoconductive scaffolds for bone tissue engineering.en_HK
dc.languageengen_HK
dc.publisherTrans Tech Publications Ltd. The Journal's web site is located at http://www.scientific.neten_HK
dc.relation.ispartofKey Engineering Materialsen_HK
dc.rightsKey Engineering Materials. Copyright © Trans Tech Publications Ltd.en_HK
dc.subjectBiodegradable polymeren_HK
dc.subjectBiomimeticsen_HK
dc.subjectBone-like apatiteen_HK
dc.subjectSimulated body fluiden_HK
dc.titleAccelerated formation of bone-like apatite on biodegradable polymer substratesen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1013-9826&volume=284-286&spage=509&epage=512&date=2005&atitle=Accelerated+formation+of+bone-like+apatite+on+biodegradable+polymer+substratesen_HK
dc.identifier.emailWang, M:memwang@hku.hken_HK
dc.identifier.authorityWang, M=rp00185en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.4028/www.scientific.net/KEM.284-286.509-
dc.identifier.scopuseid_2-s2.0-34249009252en_HK
dc.identifier.hkuros98920en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34249009252&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume284-286en_HK
dc.identifier.spage509en_HK
dc.identifier.epage512en_HK
dc.publisher.placeSwitzerlanden_HK
dc.identifier.scopusauthoridChen, Y=8643007600en_HK
dc.identifier.scopusauthoridMak, AFT=35516744100en_HK
dc.identifier.scopusauthoridWang, M=15749714100en_HK

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